Biomedical subjects

Chiu-Chu Lin

Publications and source records attributed to Chiu-Chu Lin.

6 recordsLinked to original sources

PubMed2006

[Using self-regulation theory to develop an intervention protocol for fluid control in patients undergoing hemodialysis].

With improvements in medical techniques, the survival rates among patients undergoing dialysis are gradually increasing. Poor fluid control leads to overweight and related complications. It is therefore important that new strategies be developed to encourage and maintain fluid control in patients receiving hemodialysis treatment. Self-regulation theory is a model that could be used to develop new strategies. On the basis of this theory, this article aims to design an intervention protocol for fluid control in hemodialysis patients. Examples are provided to describe how such a protocol might be applied to improve the fluid control. It is hoped that through behavioral modification of fluid control, patients undergoing hemodialysis will maintain the interdialytic weight gain and that cases of cardiovascular disease resulting from fluid overload will be reduced.

Body Fluids↗

PubMed2006

[Applying self-regulation theory to develop an exercise protocol for diabetes mellitus].

The prevalence and mortality rates for diabetes in Taiwan have gradually increased in recent years. Moreover, according to the Bureau of National Health Insurance in 1998, diabetes accounts for 11.5% of overall health care spending in Taiwan, which imposes a substantial cost burden on society and patients. From the perspective of economics, exercise is the most effective, and yet the hardest behavior for patients to carry out in terms of diabetes control. Self-regulation theory is a model that can be used to develop effective strategies for behavioral modification. We designed activities for a diabetes exercise protocol on the basis of three components (i.e., self-monitoring, self-judgment and self-reaction) of self-regulation theory. It is expected that this protocol will effectively improve patients' exercise behavior.

Diabetes Mellitus↗

PubMed2006

[Preliminary report on the efficacy of using a diet behavioral modification protocol to control glycemic levels in a patient with type 1 diabetes].

Diet control has been an important integrant part of diabetic treatment programs. However, studies have reported that diet control is the most difficult component of the diabetic self-management program for diabetic patients to follow. Many researches support the positive effects of behavioral modification on diet control. In this paper, we designed a diet behavioral modification protocol and applied this protocol to a patient with type 1 diabetes based on the transtheoretical model. Initial results indicate that this protocol helps this patient improve her HbA1c value.

Adolescent↗

PubMed2005

Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease.

BACKGROUND: It has been proven that extracellular matrix turnover is involved in the pathogenesis of various renal fibrosis diseases. Matrix metalloproteinase-2 and -9 (MMP-2 and -9) are the extracellular matrix degrading enzymes that are believed to play important roles in renal diseases. However, the relationship of circulating levels of MMP-2, -9 and serum creatinine in the patients of chronic kidney disease (CKD) has not yet been investigated. METHODS: Gelatin zymography and ELISA were employed to measure MMP-2 and MMP-9 activities in the plasma samples of 60 CKD patients and 40 control subjects. RESULTS: Serum creatinine concentrations and MMP-2 activities were significantly higher (p<0.001) while MMP-9 activity and creatinine clearance (CCr) were significantly lower (p<0.05 and p<0.001, respectively) in CKD patients, as compared with those of control subjects. In addition, serum creatinine concentrations correlated with MMP-2 activity (R=0.288, p<0.05) and inversely correlated with that of MMP-9 (R=0.344, p<0.01). CONCLUSIONS: This study demonstrated a correlation between MMP-2, -9 and serum creatinine in CKD patients to suggest that MMP-2 and MMP-9 might contribute in the pathogenesis of CKD.

Adult↗

PubMed2005

Formation of 8-nitroguanine in blood of patients with inflammatory gouty arthritis.

BACKGROUND: NOx causes DNA damage due to an inflammatory effect of gouty arthritis. We investigated the concentration of 8-nitroguanine (8-NO(2)-G) in the blood of patients with arthritis. METHODS: Subjects were divided into 3 groups: (1) high inflammatory (HI) group (n = 21) with hyperuricemia (mean, 8.9 mg/dl) and leukocytosis, (2) low inflammatory (LI) group (n = 14) with mild hyperuricemia (mean, 7.6 mg/dl) but normal leukocyte count, (3) non-inflammatory (NI) healthy control (n = 19) with mean serum uric acid concentration 5.3 mg/dl and normal leukocyte count. Serum C-reactive protein (CRP) concentrations were measured by a visual agglutination method. The blood concentrations of 8-NO(2)-G were determined by high performance liquid chromatography-electrochemical detection and were compared between groups. RESULTS: There was significant difference in percentage of positive CRP (NI: 55.6%, LI: 64.3%, HI: 100%, p = 0.003) between the 3 groups. The leukocyte count (mean +/- S.E., NI: 7400 +/- 528, LI: 7686 +/- 433, HI: 10952 +/- 691/mm(3), p < 0.001), uric acid (NI: 5.3 +/- 0.24, LI: 7.6 +/- 0.4, HI: 8.9 +/- 0.36 mg/dl, p < 0.001), NO(2) (NI: 6.5 +/- 1.2, LI: 11.1 +/- 2.9, HI: 35.6 +/- 5.1 microg/ml, p < 0.001) and the 8-NO(2)-G (NI: 0.08 +/- 0.03; LI: 0.34 +/- 0.13; HI: 0.59 +/- 0.09 ng/microg DNA, p = 0.002) were significantly increased by inflammation. CONCLUSION: Gouty inflammation induces DNA damage by increasing 8-NO(2)-G through endogenous NO and ROS formation.

Adolescent↗

PubMed2005

The phenomenology of deciding about hemodialysis among Taiwanese.

The purpose of this study was to describe the experience of making hemodialysis choices among Taiwanese with end-stage renal disease (ESRD). Using Colaizzi's phenomenological method, 12 ESRD patients provided in-depth, audiotaped interviews that were then transcribed and analyzed. The results of the data analysis revealed three broad categories and ten themes. The first category, confronting the dialysis treatment, included four themes: fear caused by false beliefs, a sense of threat to life, concern about the impairment of self-concept, and fear of physical limitations. The second category, seeking further information, included three themes: getting opinions of family members, seeking professional confirmation, and exploring alternative treatments. The third category, living with dialysis, included three themes: worsening symptoms, support of the family, and law of causation. These categories and themes revealed the difficulties that ESRD patients dealt with and the influence these difficulties and their culture had on the treatment choice.

Adaptation, Psychological↗