Biomedical subjects

Chris Hughes

Publications and source records attributed to Chris Hughes.

4 recordsLinked to original sources

PubMed2005

Relationship between active cervical range of motion and perceived neck disability in community dwelling elderly individuals.

PURPOSE: The purpose of our study was to determine the relationship between perceived neck disability and active cervical range of motion (ROM). METHODS: Twenty-three senior center attendees aged 60 to 90 participated. Their ROM was measured using the cervical range of motion instrument (CROM). Perceived neck disability was characterized using the Neck Disability Index (NDI). Pearson correlations were used to describe the relationships between CROM measurements and the NDI scores. RESULTS: No CROM measurement was correlated strongly or significantly with the NDI score. The correlations ranged from 0.009 for left lateral flexion to 0.411 for right rotation. CONCLUSIONS: CROM and NDI measurements were not related. Impairments in variables other than cervical ROM may need to be addressed if the reduction of neck disability is intended in elders.

Aged↗

PubMed2005

Counting swabs.

Explore the source record for details and available documents.

Foreign Bodies↗

PubMed2003

What do students want? The types of learning activities preferred by final year medical students.

CONTEXT: A well-aligned curriculum has consistent focus on curricular goals, teaching/learning activities and assessment. Poor alignment affects the way students budget learning time and may interfere with achievement of curricular goals. We noticed students' poor attendance in clinical clerkships prior to final examinations and hypothesised that they were responding to curricular misalignment. OBJECTIVES: To quantify the extent to which students and tutors perceived a mismatch between activities pertaining to their current clerkship and those they thought necessary to prepare for final examinations and internship. SUBJECTS: Medical students in final (sixth) year clerkships in medicine, surgery and critical care and clinical tutors. METHOD: A self-report questionnaire on time spent in clerkship activities was administered 3 months before the final examinations. RESULTS: The amounts of time spent on current activities were fairly evenly spread over teaching, study and self-directed patient contacts, and observing patient care (ward rounds, operating theatre, accident and emergency, outpatient department and clinical meetings). Less time was available for recreation. Students and tutors concurred, independently, that good examination and internship preparation required a shifting of the balance. Examination preparation redistributed time from observing patient care and recreation to study and self-directed patient contacts. Internship preparation redistributed time from teaching and recreation to observing patient care. CONCLUSION: Students and tutors perceived that current activities were not well aligned with assessment requirements but were better aligned with the requirements of internship. If we want students to direct their attention towards curricular goals, we need to bring goals, teaching/learning activities and assessment into alignment.

Australia↗

PubMedDate not supplied

Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors.

Antigen-specific T lymphocytes are attractive as potential anticancer agents. The generation of large numbers of antigen-specific T cells is possible through the use of gene therapy to express targeting receptors on the T lymphocyte. Activated T lymphocytes were transduced to express carcino-embryonic antigen or neural cell adhesion molecule targeted CD3zeta chimeric immune receptors. The chimeric receptors were expressed as homodimers and also as heterodimers with the native CD3zeta. T lymphocyte populations were expanded in the absence of selection for the modified cells and were shown to produce cytokines when cultured in the presence of immobilized purified protein antigen. These lymphocytes also responded by cytokine production and cytolytic activity when challenged with tumor-cell lines expressing the antigen recognized by the chimeric immune receptor. The cytolytic activity appears to be largely perforin mediated. Furthermore, soluble carcino-embryonic antigen did not interfere with the functional activity of the carcino-embryonic antigen-targeted lymphocytes. Long-term (5-day) stimulation of the modified lymphocytes by protein antigen resulted in reduced viability similar to that induced by anti-CD3 antibodies alone. Viability was improved by a costimulatory signal indicating that such signals may be vital in the maintenance of long-term functional activity of receptor modified T lymphocytes.

Antigens, Neoplasm↗