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Biomedical subjects

Chris Watson

Publications and source records attributed to Chris Watson.

10 recordsLinked to original sources
PubMed2005

Emerging treatments for child and adolescent social phobia: a review.

Social anxiety disorder, or social phobia (SP), is an anxiety disorder characterized by excessive fear of exposure to situations that involve potential scrutiny by others. SP is a common psychiatric problem in children and adolescents, often presenting with comorbid anxiety and mood disorders. Although the onset of SP is typically in late childhood or early adolescence, most afflicted individuals go undiagnosed for years, not seeking treatment until adulthood. First-line treatments for SP in adults support the use of pharmacotherapy and cognitive behavioral therapy. There is new and emerging data in youths with SP to support the use of similar treatments. This paper will review the clinical characteristics, epidemiology, and treatment of SP in youths. Current investigations using selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors, benzodiazepines, and monoamine oxidase inhibitors in youths will be reviewed. Several studies on the use of cognitive behavioral therapy in youths will also be examined. Practical guidelines for clinicians who treat children and adolescents are also presented.

Adolescent↗
PubMed2003

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors.

This review addresses key pharmacology and virology issues relevant in discovery and development of CCR5 antagonists as anti-HIV drugs, such as target validation, receptor internalization, allosterism, viral resistance and tropism. Recent progress in the discovery and development of CCR5 antagonists, SAR and clinical status are reviewed. Finally, modeling-based structure of CCR5 is discussed in the context of a small-molecule antagonism of the CCR5 receptor.

Animals↗
PubMed2002

Speech production errors in adults with and without Down syndrome following verbal, written, and pictorial cues.

Adults with Down syndrome and adults with developmental delays not related to Down syndrome were asked to read, repeat, and formulate speech from a picture following the presentation of 2- and 4-word and picture sequences. The speech sequences were produced either immediately after stimulus presentation or following a 5-sec response delay. Overall, participants with Down syndrome produced more memory errors than persons without Down syndrome. Participants with Down syndrome also committed more speech production errors than the other participants, but only when they were required to repeat what they had heard, or to formulate speech from pictures. The speech production performance of the two groups was equivalent in the read condition. These results are discussed with reference to Elliott, Weeks, and Elliott's (1987) model of cerebral specialization, and to verbal short-term memory in persons with Down syndrome.

Adult↗
PubMed2002

CCR5 chemokine receptors: gatekeepers of HIV-1 infection.

With the discovery that CCR5 is the critical protein required for infection by M-tropic HIV, has come huge research efforts, both in academia and industry, to try to exploit this finding. Thus, research advances in the fields of virology, structural protein chemistry, and receptor pharmacology have combined to add a new understanding to the process of HIV fusion and possible mechanisms to prevent HIV entry. This review will approach this field from a receptor pharmacology viewpoint and outline some concepts of receptor allosterism and protein-protein interaction which may be relevant to CCR5 blockade. Many of these ideas may be explored in a practical sense with the advent of new small molecule CCR5 inhibitors currently entering the clinic.

Acquired Immunodeficiency Syndrome↗