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Biomedical subjects

Christian Mølgaard

Publications and source records attributed to Christian Mølgaard.

24 records · Page 2Linked to original sources
PubMed2003

Degree of fatness after treatment of malignant lymphoma in childhood.

BACKGROUND: Sex hormone deficiency or growth hormone deficiency may cause excess fatness after treatment for childhood malignant lymphoma. Previous studies of the body composition after treatment for childhood cancer included few survivors of malignant lymphoma who were not analysed separately. PROCEDURE: We measured the whole-body percent fat by dual energy X-ray absorptiometry (DXA) and the body-mass index (weight/height(2) (kg/m(2)), BMI) in survivors of childhood Hodgkin disease (n = 23) or non-Hodgkin lymphoma (n = 21) a median of 11 years after diagnosis (range 2-25). Results were compared with local data on 463 healthy controls. RESULTS: Adjusted for sex and age, the mean BMI did not differ from that of local controls, but the mean whole-body percent fat was significantly increased (0.8 SD above predicted, P = 0.0001). Sixteen of 44 participants had a percent fat above the 90 percentile of the reference values, which indicates excess fatness. Adjusted for sex and age, percent fat was significantly higher in persons treated for non-Hodgkin lymphoma. Controlled for this, the whole-body percent fat was not significantly related to sex, age at diagnosis, length of follow-up, sex hormone therapy at follow-up or the cumulative dose of corticosteroids or doxorubicin. CONCLUSIONS: Eleven years after diagnosis of childhood Hodgkin disease or non-Hodgkin lymphoma, the whole-body percent fat was increased whereas the BMI was like that of the controls. This indicates a reduced lean body mass.

Adolescent↗
PubMed2003

Vitamin D and bone health in early life.

Prolonged vitamin D deficiency resulting in rickets is seen mainly during rapid growth. A distinct age distribution has been observed in the Copenhagen area where all registered hospital cases of rickets were either infants and toddlers or adolescents from immigrant families. Growth retardation was only present in the infant and toddler group. A state of deficiency occurs months before rickets is obvious on physical examination. Growth failure, lethargy and irritability may be early signs of vitamin D deficiency. Mothers with low vitamin D status give birth to children with low vitamin D status and increased risk of rickets. Reports showing increasing rates of rickets due to insufficient sunlight exposure and inadequate vitamin D intake are cause for serious concern. Many countries (including the USA from 2003) recommend vitamin D supplementation during infancy to avoid rickets resulting from the low vitamin D content of human milk. Without fortification only certain foods such as fatty fish contain more than low amounts of vitamin D, and many children will depend entirely on sun exposure to obtain sufficient vitamin D. The skin has a high capacity to synthesize vitamin D, but if sun exposure is low vitamin D production is insufficient, especially in dark-skinned infants. The use of serum 25-hydroxyvitamin D to evaluate vitamin D status before development of rickets would be helpful; however, there is no agreement on cut-off levels for deficiency and insufficiency. Furthermore, it is not known how marginal vitamin D insufficiency affects children's bones in the long term.

Adolescent↗
PubMed2003

A novel dual radio- and stable-isotope method for measuring calcium absorption in humans: comparison with the whole-body radioisotope retention method.

BACKGROUND: Dietary calcium absorption can be determined only with the use of isotope techniques. Currently used isotope techniques require exclusive equipment or are not true tracer approaches. OBJECTIVE: The objective was to compare a dual-isotope method combining radioisotopes and stable isotopes with a whole-body radioisotope retention method for measuring calcium absorption. DESIGN: Seven healthy adults aged 21-27 y consumed a test meal containing 63 +/- 14 (macro x +/- SD) mg Ca together with a water solution of (47)Ca (0.11 MBq). One hour after ingestion, 18 mg (44)Ca was administered intravenously. All feces and urine were collected for 5 and 6 d, respectively. Calcium absorption was estimated from whole-body retention of the radioisotope 12 times over 3 wk after ingestion and from the excretion of (47)Ca and (44)Ca in a 24-h urine sample collected on day 2. (44)Ca in urine was determined by inductively coupled plasma mass spectrometry. RESULTS: Mean (+/- SD) calcium absorption was 75 +/- 9% with the dual-isotope method and was 74 +/- 8% with the whole-body radioisotope retention method. There was a high degree of agreement between the methods. CONCLUSION: The dual-isotope method is a valid approach for measuring calcium absorption from a single meal.

Administration, Oral↗
PubMed2002

[Body mass index. Reference values for 0-45-year-old Danes].

INTRODUCTION: Our aim was to establish body mass index (weight/height2 [kg/m2], BMI) reference values for 0- to 45-year-old Danes. MATERIAL AND METHODS: A national sample that was used to generate the current Danish height and weight reference (29,106 measurements in 1965-1977; age 0-21 years; sample I). Four samples from Copenhagen (3391 measurements in 1981-1985; age 7-45 years; samples II and III and 2608 measurements in 1991-1994; age 6-45 years; samples IV and V). With the LMS method for smoothing the curves, Danish BMI reference values by age and sex were constructed from samples I and II. BMI values from two recently examined, but smaller, Danish cohorts (samples IV and V) were compared with the reference values to assess the secular trend in BMI. RESULTS: The Danish BMI reference values are presented graphically. Graphs can be downloaded from http://www.paediatri.dk. In the more recently examined samples, the mean BMI was significantly increased in children and adolescents (SD score 0.19, P = 0.0007), but unchanged in young adults (SD score 0.01, P = 0.49). DISCUSSION: For clinical purposes, we recommend comparison of the BMI of Danish children and adolescents with the present Danish reference values and new internationally based cut-off values. The BMI of Danish adults should be compared with the WHO cut-off values. Cut-off values or national or internationally used BMI reference values can be used for research, depending on the purpose.

Adolescent↗
PubMed2002

Effect of protein intake on bone mineralization during weight loss: a 6-month trial.

OBJECTIVE: The long-term effect of dietary protein on bone mineralization is not well understood. RESEARCH METHODS AND PROCEDURES: Sixty-five overweight (body mass index, 25 to 29.9 kg/m(2)) or obese (> or =30 kg/m(2)) subjects were enrolled in a randomized, placebo-controlled, 6-month dietary-intervention study comparing two controlled ad libitum diets with matched fat contents: high protein (HP) or low protein (LP). Body composition was assessed by DXA. RESULTS: In the HP group, dietary-protein intake increased from 91.4 g/d to a 6-month intervention mean of 107.8 g/d (p < 0.05) and decreased in the LP group from 91.1 g/d to 70.4 g/d (p < 0.05). Total weight loss after 6 months was 8.9 kg in the HP group, 5.1 kg in the LP group, and none in the control group. After 6 months, bone mineral content (BMC) had declined by 111 +/- 13 g (4%) in the HP group and by 85 +/- 13 g (3%) in the LP group (not significant). Loss of BMC was more positively correlated with loss of body fat mass (r = 0.83; p < 0.0001) than with loss of body weight. Six-month BMC loss, adjusted for differences in fat loss, was greater in the LP group than in the HP group [difference in LP vs. HP, 44.8 g (95% confidence interval, 16 to 73.8 g); p < 0.05]. Independent of change in body weight and composition during the intervention, highprotein intake was associated with a diminished loss of BMC (p < 0.01). DISCUSSION: Body-fat loss was the major determinant of loss of BMC, and we found no adverse effects of 6 months of high-protein intake on BMC.

Absorptiometry, Photon↗