Biomedical subjects

Christopher C Beltzner

Publications and source records attributed to Christopher C Beltzner.

2 recordsLinked to original sources

PubMed2002

Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2).

A novel class of potent human cytosolic phospholipase A(2) (GIVA PLA(2)) inhibitors was developed. These inhibitors were designed to contain the 2-oxoamide functionality and a free carboxyl group. Among the compounds tested, a long-chain 2-oxoamide containing L-gamma-norleucine was the most potent inhibitor, causing a 50% decrease in GIVA PLA(2) activity at 0.009 mole fraction.

Amides↗

PubMed2002

Structure and function of the Arp2/3 complex.

The Arp2/3 complex, a 220 kDa macromolecular assembly comprising two actin-related proteins and five other subunits, plays a key role in cellular motility by initiating the polymerization of new actin filaments. Crystal and cryo-electron microscopic structures of the Arp2/3 complex and branch junctions have clarified extensive biochemical data on the mechanism of this process.

Actin-Related Protein 2↗