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Biomedical subjects

Christopher Chubb

Publications and source records attributed to Christopher Chubb.

2 recordsLinked to original sources

A regulatory framework for controlling effluent discharges using toxicity testing in the UK.

Legislation designed to regulate effluent discharges is expressed in terms of minimising the risk of harm of that discharge to the environment. Practical implementation is usually based on the control and measurement of a limited number of individual chemicals. However, this is not always effective because of the complex nature of some discharges or the lack of data for some chemicals, preventing the definition of acceptable levels in the environment. Direct Toxicity Assessment (DTA) clearly has a role in such circumstances because it avoids the need for a comprehensive chemical characterisation of effluent discharges. Several scenarios in which DTA can play a useful role in water quality management under current legislation have been identified. A 'generic' framework for the implementation of bioassays for effluent control is proposed. This provides a number of options in terms of the level of environmental protection afforded and the 'starting point' for a DTA programme (i.e. whether it is based on local measurable impacts on water quality or directed from the outset towards the risk assessment of particular discharges). A DTA programme can be developed that meets both the technical and regulatory requirements of these different scenarios. Guidance on the design of such programmes for different scenarios is provided.

Animals↗

Effects of partial liquid ventilation on cerebral blood flow and cerebral metabolism in neonatal lambs.

BACKGROUND/PURPOSE: Liquid ventilation is a promising therapy for respiratory failure. The effects of perfluorochemical on cardiac output have not been well described. The purpose of this study was to compare cerebral blood flow (Q(CAROTID)) and cerebral metabolic rates (CMR) during conventional ventilation (CV) and partial liquid ventilation (PLV). METHODS: Five 2-week-old lambs underwent tracheostomy and central venous, aortic, and postcerebral venous catheter placement. Doppler flow probes were placed around the common ovine trunk, and the lambs underwent CV for 1 hour. Ventilation was adjusted to maintain physiologic blood gases. Pre- and postcerebral blood gas, glucose, and lactate samples were obtained every 15 minutes. Perfluorodecalin then was instilled endotracheally. The lambs underwent 1 hour of PLV with similar sampling. Data were analyzed using the Wilcoxon matched pairs test, significance at P </=.05. RESULTS: The authors observed no difference in mean Q(CAROTID) or carotid vascular resistance between CV and PLV (P =.35 and.34, respectively). The CMR of oxygen, glucose, and lactate were calculated using the Fick principle. CMR was unchanged between modes (P =.5). CONCLUSIONS: PLV did not adversely alter Q(CAROTID) or CMR in lambs, implying that this mode of ventilation should be safe in neonatal patients at risk for neurologic injury.

Airway Resistance↗