Biomedical subjects

Christopher J Patrick

Publications and source records attributed to Christopher J Patrick.

32 records · Page 2Linked to original sources

PubMed2004

Using latent trait modeling to conceptualize an alcohol problems continuum.

Recent research points toward the viability of conceptualizing alcohol problems as arrayed along a continuum. Nevertheless, modern statistical techniques designed to scale multiple problems along a continuum (latent trait modeling; LTM) have rarely been applied to alcohol problems. This study applies LTM methods to data on 110 problems reported during in-person interviews of 1,348 middle-aged men (mean age=43) from the general population. The results revealed a continuum of severity linking the 110 problems, ranging from heavy and abusive drinking, through tolerance and withdrawal, to serious complications of alcoholism. These results indicate that alcohol problems can be arrayed along a dimension of severity and emphasize the relevance of LTM to informing the conceptualization and assessment of alcohol problems.

Adult↗

PubMed2004

Identifying psychopathy subtypes on the basis of personality structure.

The authors used model-based cluster analysis to identify subtypes of criminal psychopaths on the basis of differences in personality structure. Participants included 96 male prisoners diagnosed as psychopathic, using the Psychopathy Checklist Revised (PCL-R; R. D. Hare, 1991). Personality was assessed using the brief form of the Multidimensional Personality Questionnaire (MPQ-BF; C. J. Patrick, J. J. Curtin, and A. Tellegen, 2002). The best-fitting model yielded two clusters. Emotionally stable psychopaths were characterized by low Stress Reaction and high Agency. Aggressive psychopaths were characterized by high Negative Emotionality, low Constraint, and low Communion. These results suggest that psychopaths as defined by the PCL-R includes distinct subtypes, distinguishable in terms of personality structure, that may reflect different etiologies.

Adult↗

PubMed2004

Emotional modulation of the post-auricular reflex.

A large literature now exists on emotional modulation of the startle blink reflex. The current study examined affective modulation of the post-auricular reflex, which can be measured in relation to the same noise probe used to evoke the startle reflex. We recorded the post-auricular reflex during viewing of pictures that varied systematically in emotional valence, content, and intensity. A significant linear valence modulation effect was found, with pleasant pictures potentiating and aversive pictures inhibiting the post-auricular reflex in comparison with neutral pictures. This modulatory effect did not vary as a function of picture content, but it was most robust for highly intense emotional pictures. Implications for the assessment of basic emotional action tendencies are discussed.

Adult↗

PubMed2004

Criterion-related validity of the three-factor model of psychopathy: personality, behavior, and adaptive functioning.

The Psychopathy Checklist-Revised (PCL-R) has been conceptualized as indexing two distinct but correlated factors. Previous research has established that these factors demonstrate distinct patterns of relations with external criteria. However, more recent findings suggest that the PCL-R psychopathy construct may encompass three distinguishable factors, reflecting affective, interpersonal, and behavioral symptoms. Here, we evaluated the validity of this newer three-factor model of the PCL-R factors with reference to external criteria from the domains of personality, antisocial behavior; and adaptive functioning in a sample of 310 incarcerated offenders. The interpersonal factor was related to social dominance, low stress reactivity, and higher adaptive functioning; the affective factor was correlated with low social closeness and violent offending; and the behavioral factor was associated with negative emotionality, disinhibition, reactive aggression, and poor adaptive functioning. These findings provide support for the convergent and discriminant validity of these psychopathy facets.

Adult↗

PubMed2003

Deleterious effects of alcohol intoxication: diminished cognitive control and its behavioral consequences.

The authors tested the hypothesis that impaired behavioral performance during intoxication results partly from alcohol's deleterious effects on cognitive control. The impact of alcohol on perseverative behavior was examined with an n-back working memory task that included manipulations of task complexity and prepotency of inclinations to respond or withhold responding. Thirty-two social drinkers (16 men) participated in either an alcohol (.075g/100ml) or a no-alcohol condition. Alcohol increased perseveration of prepotent, task-inappropriate response patterns only under cognitively demanding (heavy memory load) conditions. This effect was evident for both commission errors (response persistence despite contingencies altered to require restraint) and omission errors (failure to respond when contingencies were revised to encourage action). Findings suggested that alcohol-induced perseveration arises from impairments in cognitive control.

Adult↗

PubMed2003

Factor structure of the psychopathic personality inventory: validity and implications for clinical assessment.

Psychopathy is a personality disorder characterized by impulsive antisocial deviance in the context of emotional and interpersonal detachment. A factor analysis of the subscales of the Psychopathic Personality Inventory (PPI) yielded evidence for 2 factors. One factor showed relations with external criteria mirroring those of the emotional-interpersonal facet of psychopathy, including high dominance, low anxiety, and venturesomeness. The other factor showed relations paralleling those of the social deviance facet of psychopathy, including positive correlations with antisocial behavior and substance abuse, negative correlations with socioeconomic status and verbal ability, and personality characteristics including high negative emotionally and low behavioral constraint. Findings support using the PPI to assess these facets of psychopathy in community samples and to explore their behavioral correlates and genetic-neurobiological underpinnings.

Adult↗

PubMed2003

The psychophysiology of anxiety disorder: fear memory imagery.

Psychophysiological response to fear memory imagery was assessed in specific phobia, social anxiety disorder, panic disorder with agoraphobia, post-traumatic stress disorder (PTSD), and healthy controls. Heart rate, skin conductance, and corrugator muscle were recorded as participants responded to tone cues signaling previously memorized descriptor sentences. Image contents included personal fears, social fears, fears of physical danger, and neutral (low arousal) scenes. Reactions to acoustic startle probes (eyeblink) were assessed during recall imagery and nonsignal periods. Participants were significantly more reactive (in physiology and report of affect) to fear than neutral cues. Panic and PTSD patients were, however, less physiologically responsive than specific phobics and the socially anxious. Panic and PTSD patients also reported the most anxiety and mood symptoms, and were most frequently comorbidly depressed. Overall, physiological reactivity to sentence memory cues was greatest in patients with focal fear of specific objects or events, and reduced in patients characterized by generalized, high negative affect.

Acoustic Stimulation↗

PubMed2002

Aversive Pavlovian conditioning in psychopaths: peripheral and central correlates.

Differential aversive Pavlovian conditioning with a foul odor as unconditioned stimulus (US) and neutral faces as conditioned stimuli (CS) was compared between 9 noncriminal psychopaths as defined by the Hare Psychopathy Checklist Revised and 12 healthy controls. Event-related potentials (ERP), heart rate, skin conductance response, corrugator EMG, and startle response potentiation as well as valence, arousal, and contingency of the CS were assessed. Whereas the healthy controls (HC) showed significant CS +/CS- differentiation, the psychopaths (PP) failed to exhibit a conditioned response although unconditioned responses were comparable between the groups. N100, P200, and P300 to the CSs revealed that psychopaths were not deficient in information processing and showed even better anticipatory responding than the HC group indicated by the terminal contingent negative variation (tCNV), that lacked, however, CS+ and CS- differentiation. These data indicate a deficit in association formation in psychopaths that may be related to deficient interaction of limbic-subcortical and cortical structures.

Adult↗

PubMed2002

Affective imagery and the startle response: probing mechanisms of modulation during pleasant scenes, personal experiences, and discrete negative emotions.

Two experiments addressed the following issues concerning modulation of the acoustic startle reflex during emotional imagery: (1) Is startle inhibited or potentiated during imagery of pleasurable events? (2) Does startle modulation differ for personal versus standard imagery scenes? (3) Is startle modulated differently during anger versus fear? For standard scenes, startle was greater during aversive than pleasant imagery, with both exceeding neutral. Blink potentiation was greater during imagery of personal pleasant than nonpersonal pleasant scenes. Startle potentiation did not differ for anger versus fear material, but differences were found in self-report, corrugator EMG, and HR response. These results suggest that in addition to the emotional valence of imagined material, startle reactivity is influenced by the degree of engagement or active disengagement from the sensory environment. The findings also indicate that fear and anger are differentiable in terms of affective report, cardiac mobilization, and expressive behavior, but not at the primary motivational level at which reflex priming occurs.

Adolescent↗

PubMed2002

A direct assessment of the role of state and trait negative emotion in aggressive behavior.

Affective priming of aggression was examined in groups low and high in trait negative emotionality (NEM) using a Buss aggression paradigm. Negative affect was induced by exposure to aversive air blasts during some intervals (threat) and not others (safe). Phasic negative affect was assessed using startle reflex potentiation, and tonic distress was indexed by startle sensitization. Participants delivered shocks faster during threat versus safe intervals, indicating that phasic distress primed aggression. Following initial exposure to air blasts, high NEM participants showed enhanced tonic distress and delivered persistently more intense shocks than low NEM participants. These findings indicate that sustained negative affect biases high stress-reactive individuals toward more intense acts of aggression, with phasic distress affecting the rapidity of aggressive response.

Adult↗

PubMed2002

Development and validation of a brief form of the Multidimensional Personality Questionnaire.

The Multidimensional Personality Questionnaire (MPQ; A. Tellegen, 1982, in press) provides for a comprehensive analysis of personality at both the lower order trait and broader structural levels. Its higher order dimensions of Positive Emotionality, Negative Emotionality, and Constraint embody affect and temperament constructs, which have been conceptualized in psychobiological terms. The MPQ thus holds considerable potential as a structural framework for investigating personality across varying levels of analysis, and this potential would be enhanced by the availability of an abbreviated version. This article describes efforts to develop and validate a brief (155-item) form, the MPQ-BF. Success was evidenced by uniformly high correlations between the brief- and full-form trait scales and consistency of higher order structures. The MPQ-BF is recommended as a tool for investigating the genetic, neurobiological, and psychological substrates of personality.

Adolescent↗

PubMed2002

An evaluation of relations among antisocial behavior, psychopathic traits, and alcohol problems in incarcerated men.

BACKGROUND: The association between antisocial behavior and alcohol problems is well established, but the role that psychopathic traits and other factors such as drinking patterns and motives and family history play in this relationship has not been subjected to much empirical scrutiny. METHODS: A large sample (n=329) of male Federal Correctional Institution inmates participated in structured interviews designed to permit diagnosis of antisocial personality disorder and to assess facets of psychopathic personality as defined by the Hare Psychopathy Checklist-Revised. Prisoners also completed self-report questionnaires that addressed alcohol use, drinking problems, motives for drinking, and paternal alcoholism history. RESULTS: Analyses revealed that the relation between antisocial behavior and alcohol problems was moderated by scores on the emotional detachment component of psychopathy, and that self-descriptions of drinking for the purpose of coping with negative emotions mediated the positive relation between antisociality and self-reported alcohol problems. CONCLUSIONS: These findings highlight complexities in the link between antisociality and drinking problems and encourage consideration of distinct facets of psychopathy to enhance understanding of it. They further suggest possible mechanisms (e.g., paternal alcoholism history, coping motives) that may contribute to the development and maintenance of alcohol problems in criminal populations.

Adult↗

PubMed2002

Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum.

A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style. The model posits a spectrum of personality and psychopathology, united by an externalizing factor linked to each phenotype within the spectrum, as well as specific factors that account for distinctions among phenotypes within the spectrum. This model fit self-report and mother-report data from 1,048 male and female 17-year-old twins. The variance of the externalizing factor was mostly genetic, but both genetic and environmental factors accounted for distinctions among phenotypes within the spectrum. These results reconcile evidence for general and specific causal factors within the externalizing spectrum and offer the externalizing factor as a novel target for future research.

Adolescent↗

PubMed1991

Genuine, suppressed and faked facial behavior during exacerbation of chronic low back pain.

Facial activity was examined as 60 female and 60 male chronic low back pain patients responded to a painful range of motion exercise during a scheduled physical examination. Subsequently, they were asked to fake the facial response to the movement inducing the most pain or to attempt to suppress evidence that they were experiencing pain when this same movement was again repeated. Facial behavior was measured using the Facial Action Coding System. Self-reports of pain also were provided. The genuine expression was consistent with that observed in previous research, but minor differences indicated that the facial display of pain reflects differences between sources of pain, social context in which pain is induced and individual differences among patients. Considerable voluntary control over the facial expression of pain was observed, although the faked expression was more an intensified caricature of the genuine expression, and an attempt to suppress the facial grimace of pain was not entirely successful as residual facial activity persisted. Self-reports were only moderately correlated with facial behavior.

Acute Disease↗