Biomedical subjects

Christopher T Clark

Publications and source records attributed to Christopher T Clark.

4 recordsLinked to original sources

PubMed2006

Primary adenoid cystic carcinoma of the breast: case report and review of the literature.

Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm accounting for 0.1% of all breast carcinomas, and presenting most commonly as a painful breast mass. In contrast to the aggressive nature of ACC at other sites, ACC of the breast has a favorable prognosis, lymph node involvement or distant metastases seldom occur. Treatment is basically of simple mastectomy. Chemotherapy, radiation and hormonal treatment have been infrequently used and evaluated. We report a case of ACC of the breast managed with mastectomy and review the literature.

Journal Article↗

PubMed2006

Primary malignant melanoma of the lung: a case report and review of the literature.

Melanomas of the respiratory tract are usually metastatic in origin, and finding a primary melanoma is very rare. We report the case of a 60-year-old man who presented with a 2-month history of cough with associated weight loss. The histopathologic findings were consistent with those of a melanoma. Before considering the diagnosis of primary melanoma of the lung, an extensive diagnostic workup was done to rule out metastasis from an occult primary tumor. In addition, previously reported cases of primary lung melanoma were reviewed, and the established criteria for determining the primary site were applied. Because the precise etiology has not yet been elucidated, the possible mechanism is discussed.

Antineoplastic Agents, Alkylating↗

PubMed2004

Efficient synthesis of acylsilanes using morpholine amides.

[reaction: see text] A general synthesis of acylsilanes from the corresponding morpholine amides and silyllithium species is described. The use of morpholine amides is economical and prevents over-addition by the silyl nucleophile. The procedure cleanly affords acylsilanes in good yields and circumvents the use of stoichiometric copper(I) cyanide typically employed to synthesize these compounds from acid chlorides.

Journal Article↗

PubMed2004

Copper(I)-catalyzed disilylation of alkylidene malonates employing a Lewis base activation strategy.

The disilylation of activated alpha,alpha-unsaturated esters has been accomplished by utilizing symmetrical disilanes and catalytic quantities of copper(I) salts in the presence of Lewis bases such as DMF. This new methodology with various alkylidene malonates is moderate to high yielding and affords alpha-silyl diesters, compounds that previously have not been readily accessible, that can be further manipulated to cleanly afford useful alpha-substituted alpha-hydroxy esters.

Journal Article↗