Biomedical subjects

Chun-lin Hou

Publications and source records attributed to Chun-lin Hou.

6 recordsLinked to original sources

PubMed2006

Restoration of shoulder abduction by transfer of the spinal accessory nerve to suprascapular nerve through dorsal approach: a clinical study.

BACKGROUND: In recent years, transfer of the spinal accessory nerve to suprascapular nerve has become a routine procedure for restoration of shoulder abduction. However, the operation via the traditional supraclavicular anterior approach often leads to partial denervation of the trapezius muscle. The purpose of the study was to introduce transfer of the spinal accessory nerve through dorsal approach, using distal branch of the spinal accessory nerve, to repair the suprascapular nerve for restoration of shoulder abduction, and to observe its therapeutic effect. METHODS: From January to October 2003, a total of 11 patients with a brachial plexus injury and an intact or nearly intact spinal accessory nerve were treated by transferring the spinal accessory nerve to the suprascapular nerve through dorsal approach. The patients were followed up for 18 to 26 months [mean (23.5 +/- 5.2) months] to evaluate their shoulder abduction and function of the trapezius muscle. The outcomes were compared with those of 26 patients treated with traditional anterior approach. And the data were analyzed by Student's t test using SPSS 10.5. RESULTS: In the 11 patients, the spinal accessory nerves were transferred to the suprascapular nerve through the dorsal approach successfully. Intact function of the upper trapezius was achieved in all of them. In the patients, the location of the two nerves was relatively stable at the level of superior margin of the scapula, the mean distance between them was (4.2 +/- 1.4) cm, both the nerves could be easily dissected and end-to-end anastomosed without any tension. During the follow-up, the first electrophysiological sign of recovery of the infraspinatus appeared at (6.8 +/- 2.7) months and the first sign of restoration of the shoulder abduction at (7.6 +/- 2.9) months after the operation, which were earlier than that after the traditional operation [(8.7 +/- 2.4) months and (9.9 +/- 2.8) months, respectively; P < 0.05]. The postoperative shoulder abduction was 62.8 degrees +/- 12.6 degrees after transfer of the spinal accessory nerve, better than that after the traditional (51.6 degrees +/- 15.7 degrees). All the 11 patients could extend and externally rotate the shoulder almost normally. CONCLUSIONS: The accessory nerve transfer through dorsal approach is a safe and reliable procedure for the treatment of brachial plexus injury. Its postoperative effect is confirmed, which is better than that of the traditional operation.

Accessory Nerve↗

PubMed2004

[Comparison of plate and Kirschner wire fixation in treatment of clavicular nonunion].

OBJECTIVE: To compare the results of plate and Kirschner wire fixation in treatment of nonunion of clavicular fracture. METHODS: From September 1991 to January 2002, 19 patients (9 with plate and 10 with Kirschner wire) were treated. The results were evaluated by reduction, bone union time, recovery of joint function, pain, and correction of deformation. RESULTS: The follow-up time was 6-23 months with an average of 11 months. Bone union occurred after a mean time of 11 weeks. In plate group, 7 patients gained excellent results, 1 good and 1 fair. In Kirschner wire group, 3 patients gained excellent results, 3 good, 3 fair and 1 poor. The result of plate is significantly better than that of Kirschner wire fixation(P < 0.05). CONCLUSION: Plate fixation is a good simple method for treatment of nonunion of clavicular fracture.

Adult↗

PubMed2003

[Experimental study on preparing chitosan-collagen matrix and subcutaneous implantation].

OBJECTIVE: To investigate the feasibility of the chitosan-collagen membrane (CCM) as a dermal substitute. METHODS: Fresh bovine tendo calcaneus collagen was dispersed in 0.5 mol/L acetic acid, co-precipitated with chitosan and lyophilized. Dry membranes were cross-linked in 0.05% glutaraldehyde for 24 hours. In vitro its degrading rate was measured by use of collagenase degrading test. The chitosan-collagen membrane was implanted to subcutaneous dorsal sites of SD rats. After implantation, histocompatibility, vascularity and degradation were observed in vivo. RESULTS: The chitosan-collagen membrane was yellowish, translucent, and porous. Pore size ranged 50-250 microns, and collagen fiber bundles were reticular arrangement in the membrane. It had slower degradation than pure collagen membrane by collagenase in vitro. Subcutaneous implantation test showed the minimal inflammation, good histocompatibility and earlier vascularization. The membrane degradation was slower in vivo. Eight weeks after implantation, organized collagen structure was retained. CONCLUSION: The chitosan-collagen membrane has better physical and biological properties, ideal histocompatibility, earlier vascularization and slower degradation. Therefore, It is an optimum substitute for dermal scaffold.

Animals↗

PubMed2003

Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs.

OBJECTIVE: To evaluate the results of a self-designed bladder controller for restoring micturition function in paraplegic dogs. METHODS: The spinal cords of 4 dogs were transected above the cone. Electrodes were implanted in S2 bilaterally and connected to the subcutaneous receivers for external activation. Microsurgical technique was employed to perform dorsal rhizotomy of S1-3 intradurally. The dogs were stimulated daily to observe micturition. Urodynamic testing and vesicography were performed. RESULTS: All the dogs acquired micturition under the control of electric stimulation, with urine volume 80-140 ml per time. The mode of micturition was post-stimulus voiding. Vesicography revealed that the bladder was filled well and the bladder neck was open in the micturition course of electric stimulation. Residual urine volume was 15-20 ml. Urodynamic testing found that the bladder pressure and intraurethral pressure increased simultaneously, but when the intraurethral pressure was greater than the bladder pressure, no micturition occurred. The pressure decreased to baseline rapidly and the bladder pressure decreased slowly between two bursts. Micturition occurred when the bladder pressure was greater than the intraurethral pressure. CONCLUSIONS: The self-designed bladder controller together with a sacral deafferentation procedure can restore micturition function of paraplegic dogs.

Animals↗

PubMed2002

[Clinical study on chitosan in prevention of knee adhesion after patellar operation].

OBJECTIVE: To investigate the clinical effect of chitosan in prevention of knee dysfunction due to adhesion after operation for patellar fracture. METHODS: From March to October 1999, 40 cases of patellar fracture were treated by internal fixation, with intra-articular injection of 2% chitosan in only 24 cases after fixation and with no chitosan injection in 16 cases (control group). The function of the knee joint, including extension and flexion, was evaluated 1 month and 1 year after operation respectively. RESULTS: One month after operation, the knees with chitosan injection could actively move in the average range of 104 degrees +/- 23 degrees, and the knees in the control group could move in the average range of 72 degrees +/- 16 degrees, which showed significant difference between two groups (P < 0.01); 1 year after operation, the range of movement of the knees with injection was 165 degrees +/- 38 degrees on average, and that of the knees in the control group was 110 degrees +/- 31 degrees, which also indicated significant difference between two groups (P < 0.05). CONCLUSION: Medical chitosan could effectively prevent or reduce the post-operative adhesion of knee joint after patellar operation.

Adolescent↗

PubMed2002

[Experimental study on bacteriostasis of chitosan and sodium hyaluronate].

OBJECTIVE: To compare the effect and coverage of bacteriostasis of chitosan and sodium hyaluronate. METHODS: Each of the five bacteria, Proteus mirabilis, Escherichia coli, Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus, was cultivated for 33 tubes of broth culture. Leaving three tubes each group as control group, ploidy diluted concentration of high relative molecular weight chitosan, low relative molecular weight chitosan and sodium hyaluronate were added respectively in the broth culture. All the tubes were cultivated for 18 hours at 37 degrees C with homeothermia. Then the growth of bacteria was observed. RESULTS: The minimal inhibitory concentrations (MIC) of high relative molecular weight chitosan were: Proteus mirabilis 0.031%, Escherichia coli 0.063%, Candida albicans 0.063%, Pseudomonas aeruginosa 0.063%, Staphylococcus aureus 0.063%; and the MIC of low relative molecular weight chitosan were: Proteus mirabilis 0.125%, Escherichia coli 0.025%, Candida albicans 0.25%, Pseudomonas aeruginosa 0.25%, Staphylococcus aureus 0.125%; bacteria grew well in each tube of sodium hyaluronate group and control group. CONCLUSION: The above results show that sodium hyaluronate has no bacteriostasis, while chitosan has bacteriostasis on broad spectrum and high relative molecular weigh: chitosan has stronger effect.

Anti-Bacterial Agents↗