PubMed Health⌕ Search

Biomedical subjects

Chung-Hsi Hsing

Publications and source records attributed to Chung-Hsi Hsing.

6 recordsLinked to original sources
PubMed2006

Tissue microarray analysis of interleukin-20 expression.

Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.

Gene Expression Profiling↗
PubMed2006

IL-20: biological functions and clinical implications.

IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data available in the literature. Our studies of IL-20 show that it is a pleiotropic cytokine with potent inflammatory, angiogenic, and chemoattractive characteristics. Inflammation and angiogenesis are essential for the pathogenesis of rheumatoid arthritis and atherosclerosis. Based on in vitro data and clinical samples, we demonstrated that IL-20 is involved in the diseases of rheumatoid arthritis and atherosclerosis. In addition, we found in our studies that IL-20 signaled through different molecules in several cells. The present review presents the clinical implications of IL-20 in rheumatoid arthritis and atherosclerosis. It may provide new therapeutic options in the future.

Amino Acid Sequence↗
PubMed2006

Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass.

BACKGROUND: Interleukin (IL)-19, IL-20, and IL-22, three novel cytokines in the IL-10 family, have recently been discovered. The biological functions and clinical implications of these cytokines are not clear. We aimed to analyze if serum levels of these cytokines were altered in inflammatory responses of postoperative cardiopulmonary bypass (CPB) and investigate the molecular mechanism involved in cytokine induction. METHODS: Twenty-five patients undergoing elective aortic-coronary bypass grafting with CPB were enrolled in this study. Blood samples withdrawn at (T1) before anesthesia, (T2) CPB start, (T3) CPB end, (T4) 4 hours post-CPB, (T5) 8 hours post-CPB, (T6) 12 hours post-CPB, (T7) 24 hours post-CPB, and (T8) 48 hours post-CPB were assayed for IL-6, IL-10, IL-19, IL-20, IL-22, and tumor necrotic factor-alpha (TNF-alpha). Transcripts of IL-19, IL-20, and IL-22 from monocytes were analyzed. In vitro, levels of IL-19, IL-20, and IL-22 production in monocytes incubated with IL-6 and TNF-alpha were determined. RESULTS: The serum levels of IL-19 and IL-22 significantly increased at T3, peaked at T5, and remained increased at T8 (p<0.001). Induction of IL-19 and IL-22 was concomitant with the change in IL-10, IL-6, and TNF-alpha levels. Interleukin-19, IL-20, and IL-22 transcripts in monocytes from patients increased after CPB. In vitro experiments showed that IL-6 and TNF-alpha upregulated IL-19 protein expression in monocytes. CONCLUSIONS: Serum IL-19 and IL-22 were induced in cardiac surgery with CPB and concomitant with induction of IL-6 and TNF-alpha. The IL-19 and these proinflammatory cytokines may interactively contribute to systemic inflammatory responses after CPB.

Aged↗
PubMed2005

Life-threatening left lung collapse combined with mediastinal shift rescued by a chest tube insertion--a case report.

Pulmonary atelectasis due to acute endobronchial blood clot impaction is not uncommon in the setting of substantial hemoptysis. Sometimes, life-threatening hypoxemia and hemodynamic changes may occur even with collapse of only one lung. Alterations of pulmonary blood flow distribution with increased pulmonary shunt could contribute to these events. In addition, abnormal negative pleural pressure caused by total lung collapse also plays an important role in these situations. Here we report a case with near-fatal left lung collapse was rescued by immediate chest tube insertion. We would like to discuss the relative pathophysiology of the condition and anesthetic management of patient in such a dangerous situation.

Adult↗
PubMed2002

Application of transesophageal echocardiography in removal of right atrial tumor thrombus of adrenal cortical carcinoma--a case report.

Surgical removal of adrenal cortical carcinoma complicated by intra-atrial tumor thrombus is very difficult and risky if the removal of thrombus is incomplete, leading possibly to pulmonary embolism. Application of multiplane transesophageal echocardiography during surgical operation may help notifying the size and location of tumor thrombus and also help determining the completeness of the thrombus removal. We present a case of successful removal of adrenal cortical carcinoma with tumor thrombus extension to the right atrium under comprehensive anesthetic care including continuous intraoperative transesophageal echocardiography monitoring.

Adrenal Cortex Neoplasms↗