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Biomedical subjects

Ciğdem Tokyol

Publications and source records attributed to Ciğdem Tokyol.

6 recordsLinked to original sources
PubMed2006

The effects of desferrioxamine and quercetin on hepatic ischemia-reperfusion induced renal disturbance.

BACKGROUND: The aim of this study was to analyze the effects of 45min of hepatic ischemia and 1h of reperfusion on renal oxidative stress parameters, on renal tissue damage, and the role of Desferrioxamin (Dfx) and Q on these parameters. METHODS: Thirty Wistar albino rats were randomized to five groups. Group I was the control group. Group II received no treatment. Groups III and IV received intramuscular injections of desferrioxamine (100mg/kg) and quercetin (50mg/kg), respectively. Group V was administered Dfx and quercetin in combination. After treatment for 3 days, groups II, III, IV, and V were exposed to total hepatic ischemia for 45min. Plasma alanine aminotransferase levels, renal malondialdehyde and reduced glutathione (GSH) activities were measured after reperfusion for 1h. Histopathological and ultrastructural analysis of renal tissues was carried out. RESULTS: Plasma creatinine and BUN levels were markedly increased in the IR group and pretreated groups. Kidney MDA increased in the IR group, Q and Dfx+Q significantly decreased kidney MDA Kidney GSH levels markedly decreased in the IR group, Dfx significantly increased kidney GSH. No evidence of overt injury was observed in any renal tissue under light and electron microscopy. CONCLUSIONS: Our data demonstrated that 45min of hepatic ischemia and 1h of reperfusion may alter renal functions and may cause oxidative stress on renal tissue. Q and Dfx seem to have a beneficial effect via the GSH system and modulation of MDA levels.

Animals↗
PubMed2004

Bacterial vaginosis: comparison of Pap smear and microbiological test results.

Our purpose was to determine the reliability of the Pap smear in making the diagnosis of bacterial vaginosis and to examine the characteristics of Pap smear vs vaginal culture in diagnosis of bacterial vaginosis, with the vaginal Gram stain used as the diagnostic standard. We performed a prospective, blinded study involving 245 women who referred to the Department of Gynecology and Obstetrics in our hospital for routine genital examination between September 2001 and September 2002. Exclusion criteria included vaginal bleeding and pregnancy. Each patient had standard Pap smear, Gram-stained vaginal smear and culture of vaginal swab. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic value of Pap smear and vaginal culture results were determined with Gram stain used as the standard for diagnosis of bacterial vaginosis. Using Gram stain diagnosis of bacterial vaginosis as the standard, Pap smear and vaginal culture test results had sensitivity of 43.1 and 77.8%, specificity of 93.6 and 97.7%, positive predictive value of 73.8 and 93.3%, negative predictive value of 79.8 and 91.4%, diagnostic value of 78.8 and 91.8%, respectively, for the diagnosis of bacterial vaginosis. Compared to the microbiological test results, Pap smear is not sensitive enough for screening of bacterial vaginosis. However, because of its high specificity, it may be an adequate diagnostic criteria when it is positive.

Adolescent↗
PubMed2004

Schwannoma of the upper lip: a case report.

Schwannomas are neurogenic tumors that arise from the Schwann cells of the nerve sheath. They are benign, usually solitary, and encapsulated neoplasms. In this report, a 29-year-old woman with a complaint of painless swelling in the upper lip is presented. Computed tomography showed a well-circumscribed solid mass. The lesion was excised and histopathologic diagnosis was made as schwannoma. The postoperative course was uneventful. No recurrence was observed during a follow-up period of 12 months.

Adult↗
PubMed2003

Bilateral second branchial cleft cysts without any associated congenital abnormality: a case report.

A thirty-year-old male patient with bilateral second branchial cleft cysts is presented, in whom no association was found with any other congenital abnormality, in particular branchio-oto-renal syndrome. He had a complaint of painless swelling on both sides of the neck. Physical and radiological examinations showed bilateral branchial cleft cysts. A coexisting congenital syndrome could not be documented despite investigations including physical examination, blood biochemistry and complete blood count, audiologic tests, temporal bone computed tomography, and abdominal and renal ultrasonography. Surgical excision was performed on both sides with a three-week interval. Histopathologic examination confirmed the diagnosis. The postoperative period was uneventful, with no recurrence during a follow-up period of 12 months.

Adult↗
PubMedDate not supplied

Cutaneous intravascular papillary endothelial hyperplasia of the hand: a case report and review of the literature.

Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign endothelial proliferation that bears a remarkable resemblance to angiosarcoma. We report a case of cutaneous IPEH in the thumb of a seven-year old girl which was successfully treated with excision. The relevant literature is reviewed and histopathological features, differential diagnosis and natural history of the lesion are discussed.

Child↗