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Cihangir Aliağaoğlu

Publications and source records attributed to Cihangir Aliağaoğlu.

11 recordsLinked to original sources
PubMed2006

A very large, rapidly developing, congenital giant cell fibroblastoma in a 5-month old infant.

Giant cell fibroblastoma is an uncommon soft tissue neoplasm that occurs in childhood. It seems to be the juvenile form of dermatofibrosarcoma protuberans, which is seen less frequently in children. Only one congenital case has been reported previously. In this report, we present a 5-month-old girl with a rapidly and atypically growing mass located on the upper part of the right scapula. We think that our case is very interesting, because no similarly large lesion (12 cm x 10 cm x 8 cm) related to giant cell fibroblastoma has been previously reported in the published work.

Dermatofibrosarcoma↗
PubMed2006

A case of early onset confluent and reticulated papillomatosis with an unusual localization.

Confluent and reticulated papillomatosis is a relatively rare dermatosis of unknown origin. It is characterized by papules that become confluent in the center and reticulated at the periphery. The sites of predilection are the neck, interscapular region, inframammary area and abdomen. In a 15-year-old girl diagnosed with confluent and reticulated papillomatosis, the lesions first appeared on her knees and elbows when she was 4-years-old, and on the interscapular area when she was 13. Similar lesions arose on the left hand a few weeks previous to her visit. Two biopsy specimens were taken from the interscapular and elbow areas. The histopathological findings of this case fit the diagnosis of confluent and reticulated papillomatosis. We expect good results from azithromycin therapy.

Adolescent↗
PubMed2006

Comedonal, cornifying and hypertrophic Darier's disease in the same patient: a Darier combination.

Our 42-year-old patient had comedonal Darier's disease (DD) on the face, comedonal cornifying DD on the upper back, and hypertrophic DD on both legs. Biopsies taken from face, upper back and medial sides of the legs were found to be compatible with these clinical subtypes. The comedonal type was in the classical place, but the hypertrophic and cornifying types were not in the usual sites. In addition to the classic histopathology of DD, we noted multiple, warty dyskeratoma-like structures in the comedonal type, marked compact hyperkeratosis in the cornifying type, and marked papillomatosis in the hypertrophic type.

Adult↗
PubMed2006

Rapidly developing giant sized lupus vulgaris on the chest associated with bilateral scrofuloderma on the neck.

Lupus vulgaris and scrofuloderma are the opposite poles of cutaneous tuberculosis. Lupus vulgaris of a giant size and scrofuloderma in the vicinity of this lesion were both present in a 70-year-old female patient. The purified protein derivative of tuberculin (PPD) skin test was strongly positive. In histopathological examination, granulomatous infiltration without caseation necrosis was seen in the dermis. The patient was treated with a four-drug therapy consisting of pyrazinamide (25 mg/kg), isoniazid (5 mg/kg), rifampin (10 mg/kg) and ethambutol (15 mg/kg) daily for 2 months, followed by dual therapy with isoniazid and rifampin for 6 months. Her cutaneous lesions significantly regressed after 4 months, leaving keloid scars.

Aged↗
PubMed2006

Frequency of sister chromatid exchanges in the lymphocytes of patients with atopic dermatitis.

The combination of genetic susceptibility and environmental factors can induce allergic sensitization and subsequent local inflammation, resulting in atopic dermatitis (AD). Sister chromatid exchange (SCE) is a sensitive method that may reflect an instability in DNA or a deficiency in DNA repair. The aim of the present study was to investigate whether patients with AD have defects in DNA repair and whether SCE frequency can be used as a genetic marker in the pathogenesis of AD. Between September 2004 and July 2005, SCE was analyzed in the peripheral blood lymphocyte chromosomes of 32 patients with AD and 28 control subjects at the Dermatology Unit of Erzurum State Hospital. This study found that the SCE frequency was significantly increased in patients with AD (P < 0.00001). The prevalence of SCE was not correlated with patient age, sex, disease duration or AD disease severity. Our results indicate that increased chromosome instability may play an important role in the etiology of AD.

Adolescent↗
PubMed2006

Is confluent and reticulated papillomatosis without papillomatosis early or late stage of confluent and reticulated papillomatosis?

The histologic findings of confluent and reticulated papillomatosis include papillomatosis, hyperkeratosis, and minimal or no acanthosis. We present a patient with the clinical findings of confluent and reticulated papillomatosis who responded dramatically to azithromycin, but histologic examination did not reveal papillomatosis. We observed invagination of basket-weave hyperkeratosis through the epidermis. We considered this finding may give a clue for the diagnosis of confluent and reticulated papillomatosis.

Acanthosis Nigricans↗
PubMed2004

Treatment of confluent and reticulated papillomatosis with azithromycin.

Confluent and reticulated papillomatosis (CRP) is a relatively rare disorder of unknown origin, mostly affecting young female adults. We here present the case of a 21-year-old male patient with confluent and reticulated papillomatosis. Skin examination revealed brownish, verrucous, hyperkeratotic, 2 to 5 mm papules, which formed confluent patches and plaques with a reticulate network on the interscapular area. The patient was initially treated with ketoconazole cream for two weeks without improvement. The disease can be rather persistent and resistant to topical therapy. Our case showed a satisfactory response to treatment with azithromycin. Although this treatment is known to be effective in some cases, the action mechanism of azithromycin on CRP is not fully understood.

Administration, Oral↗