Biomedical subjects

Clifton M Schor

Publications and source records attributed to Clifton M Schor.

18 recordsLinked to original sources

PubMed2006

The coordination of binocular eye movements: vertical and torsional alignment.

Precise binocular alignment of the visual axes is of utmost importance for good vision. The fact that so few of us ever experience diplopia is evidence of how well the oculomotor system performs this function in the face of changes due to development, disease and injury. The capacity of the oculomotor system to adapt to visual stimuli that mimic alignment deficits has been extensively explored in laboratory experiments. While the present paper reviews many of those studies, the primary focus is on issues involved in maintaining good vertical and torsional alignment in everyday viewing situations where the parsing of muscle forces may vary for the same horizontal and vertical eye positions due to changes in horizontal vergence and head posture.

Eye Movements↗

PubMed2006

Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study.

A dynamic model of ocular accommodation is used to simulate the stability and dynamic performance of accommodating intraocular lenses (A-IOLs) that replace the hardened natural ocular lens that is unable to change focus. Accommodation simulations of an older eye with A-IOL materials having biomechanical properties of a younger eye illustrate overshoots and oscillations resulting from decreased visco-elasticity of the A-IOL. Stable dynamics of an A-IOL are restored by adaptation of phasic and tonic neural-control properties of accommodation. Simulations indicate that neural control must be recalibrated to avoid unstable dynamic accommodation with A-IOLs. An interactive web-model of A-IOL illustrating these properties is available at http://schorlab.berkeley.edu.

Accommodation, Ocular↗

PubMed2006

The extended horopter: quantifying retinal correspondence across changes of 3D eye position.

The theoretical horopter is an interesting qualitative tool for conceptualizing binocular correspondence, but its quantitative applications have been limited because they have ignored ocular kinematics and vertical binocular sensory fusion. Here we extend the mathematical definition of the horopter to a full surface over visual space, and we use this extended horopter to quantify binocular alignment and visualize its dependence on eye position. We reproduce the deformation of the theoretical horopter into a spiral shape in tertiary gaze as first described by Helmholtz (1867). We also describe a new effect of ocular torsion, where the Vieth-Müller circle rotates out of the visual plane for symmetric vergence conditions in elevated or depressed gaze. We demonstrate how these deformations are reduced or abolished when the eyes follow the modification of Listing's law during convergence called L2, which enlarges the extended horopter and keeps its location and shape constant across gaze directions.

Convergence, Ocular↗

PubMed2006

Initial destination of the disaccommodation step response.

Peak velocity and peak acceleration of disaccommodation step responses remain invariant of response magnitude for a constant starting position and they increase linearly with proximity of starting position. This suggests that disaccommodation response is initiated towards an initial (default) destination and is switched mid-flight to attain the desired final destination. The dioptric location of initial destination was estimated from the x-intercept of regression of peak velocity on response starting position. The x-intercept correlated well with subject's cycloplegic refractive state and poorly with their dark focus of accommodation. Altering the dark focus by inducing fatigue in the accommodative system did not alter the x-intercept. These observations suggest that cycloplegic refractive state is a good behavioral correlate of initial destination of disaccommodation step responses.

Accommodation, Ocular↗

PubMed2005

Effects of partial occlusion on perceived slant difference.

When two slanted surfaces are placed in proximity, the perceived slant difference between them is exaggerated. This effect has been called slant contrast. When a partial occluder is presented in front of the gap between them, the perceived slant difference between the surfaces is reduced. We refer to this reduction in perceived slant difference as stereo-slant assimilation. We investigated two properties of the occluder that might affect perceived stereo-slant difference. Three vertically aligned random-dot patterns were presented either with a partial occluder over the gaps between them or without it. Observers judged the perceived slant difference between the center pattern and two surround random-dot patterns that had the same slant. The perceived slant difference was reduced when the partial occluder was present. We varied stereo-depth and slant of the occluder and found that the decreased perceived slant difference was not due to either of these. Note that the surfaces were all simulated and presented on a computer screen and the results may not apply to real surfaces. The effect of the occluder on perceived slant differences could have resulted from either a reduction of slant contrast or an increase of slant assimilation.

Computer Graphics↗

PubMed2005

Adaptation to the induced effect stimulus normalizes surface slant perception and recalibrates eye position signals for azimuth.

A frontoparallel plane viewed with unequal vertical magnification of the two ocular images appears rotated about a vertical axis (i.e., induced effect; Ogle, 1938). Several experiments were conducted to investigate changes in the visual system that occurred after adapting to the induced effect. Adaptation at 57 cm was tested using tall stimuli at various viewing distances to test for the adaptation of vertical size ratio (VSR) information and normalization of the slant percept. When aftereffects were expressed in units of slant, they were larger at 57 cm than other test distances and were not significantly different from each other at other distances. Short stimuli were used to test adaptation of eye position signals for azimuth. The aftereffects were in the opposite direction to those measured with tall stimuli. The combined results suggest that the visual system normalizes slant percepts based on the surface slant of the adaptation stimulus and when there is a conflict between VSR signals and eye position cues for azimuth that the primary eye position signal for azimuth is recalibrated toward the direction indicated by the binocular differential vertical magnification in the adaptation stimulus.

Adaptation, Ocular↗

PubMed2005

Pulse-step models of control strategies for dynamic ocular accommodation and disaccommodation.

Dynamic properties and control strategies of step responses by accommodation and disaccommodation differ from one another. Peak velocity of accommodation increases with response magnitude, while peak velocity and peak acceleration of disaccommodation increase with starting position. These dynamic properties can be modeled as control strategies that use independent acceleration-pulse and velocity-step components that are integrated respectively into phasic-velocity signals that control movement and tonic-position signals that control magnitude. Accommodation is initiated toward its final destination by an acceleration-pulse whose width increases with response magnitude to increase peak velocity. Disaccommodation is initiated toward a default destination (the far point) by an acceleration-pulse whose height increases with dioptric distance of the starting position to increase peak velocity and peak acceleration. Both responses are completed and maintained by tonic-position signals whose amplitudes are proportional to the final destination. Mismatched amplitudes of phasic-velocity and tonic-position signals in disaccommodation produce unstable step responses.

Accommodation, Ocular↗

PubMed2005

Dynamic control of ocular disaccommodation: first and second-order dynamics.

Velocity and acceleration characteristics provide valuable information about dynamic control of accommodation. We investigated velocity and acceleration of disaccommodation (near-far focusing) from three starting positions. Peak velocity and peak acceleration of disaccommodation increased with the proximity of starting position however for a given starting position they were invariant of response magnitude. These results suggest that all disaccommodation responses are initiated towards a constant primary destination and are switched mid-flight to attain the desired final position. Large discrepancies between the primary destination and desired final position appear to produce overshoots and oscillations of small responses from proximal starting positions.

Accommodation, Ocular↗

PubMed2005

Stereo-slant adaptation is high level and does not involve disparity coding.

We have investigated the potential stages of visual processing at which adaptation may occur to a slanted surface produced by horizontal magnification. Predictions of three hypotheses were tested utilizing a property of depth from binocular disparity, namely that slant scales with distance. If adaptation occurs at the disparity level, then the after-effect expressed in units of horizontal magnification will be independent of the test distance. If adaptation occurs at either a perceived slant or mapping level, then the after-effect, expressed in units of slant, will be independent of the test distance. If adaptation is contingent on distance, then the after-effect will not transfer over distance. Subjects adapted to a stereo-defined slanted surface at a distance of 57 cm. The after-effect was measured with a test stimulus at a distance of 28, 57, 85, or 114 cm by means of a nulling method. When the after-effect was expressed in units of slant, we found that it was larger at the adapting distance than other test distances, and that the after-effect was constant at test distances different from the adaptation distance. These results suggest that two types of adaptation occurred, namely adaptation on a mapping/perception level and adaptation contingent on distance.

Adaptation, Ocular↗

PubMed2005

Acceleration characteristics of human ocular accommodation.

Position and velocity of accommodation are known to increase with stimulus magnitude, however, little is known about acceleration properties. We investigated three acceleration properties: peak acceleration, time-to-peak acceleration and total duration of acceleration to step changes in defocus. Peak velocity and total duration of acceleration increased with response magnitude. Peak acceleration and time-to-peak acceleration remained independent of response magnitude. Independent first-order and second-order dynamic components of accommodation demonstrate that neural control of accommodation has an initial open-loop component that is independent of response magnitude and a closed-loop component that increases with response magnitude.

Accommodation, Ocular↗

PubMed2004

A pulse-step model of accommodation dynamics in the aging eye.

We have developed a dynamic model of accommodation that combines independent phasic-velocity and tonic-position neural signals to control position, velocity and acceleration properties of accommodative step responses. Phasic and tonic signals were obtained from neural integration of a fixed-height acceleration-pulse and variable-height velocity-step respectively to control independent acceleration and velocity properties of the step response. Duration and amplitude of the acceleration-pulse are increased with age to compensate for age-related increases of visco-elastic properties of the lens to maintain youthful velocity. The model illustrates a neural control strategy that is similar to the classical neural control model of step changes by the saccadic and vergence systems.

Accommodation, Ocular↗

PubMed2004

Symmetrical horizontal vergence contributes to the asymmetrical pursuit of targets in depth.

When a target travels slowly and smoothly along the line of sight of one eye, the eye that is aligned with the target remains stationary while the other eye adducts. The mechanism that is commonly invoked is that commands signaling conjugate pursuit and symmetrical vergence are combined. The two signals are in the same direction in the adducting eye but are in the opposite direction in the stationary eye and, so, cancel. Recent data have challenged this view and the idea that the two eyes are controlled independently has been resurrected. Pursuit and vergence movements are difficult to separate when they occur together because they have similar latencies and dynamics. We have developed a method where horizontal vergence is "tagged" by training it to have a vertical vergence component that can then be identified in combined pursuit-vergence movements. Four subjects trained eye movements to have a vertical vergence component by fusing vertical disparities that varied in association with horizontal convergence. Following training, the vertical vergence aftereffect was found whenever horizontal vergence was stimulated regardless of whether the horizontal vergence resulted from movement of the target in the midsagittal plane (symmetrical vergence) or from movement of the target along the line of sight of one eye (asymmetrical vergence). The vertical vergence aftereffect was never observed in association with conjugate movements indicating that asymmetrical slow eye movements are not controlled monocularly but contain a vergence component along with symmetrical smooth pursuit.

Adaptation, Physiological↗

PubMed2004

Temporal aspects of spatial interactions affecting stereo-matching solutions.

Stereo-matching solutions minimize disparity relative to the horopter (minimum-absolute-disparity or MAD), and differences in disparity between adjacent features (minimum-relative-disparity or MRD). When placed in conflict, spatial proximity promotes MRD over MAD solutions. How does temporal proximity of neighboring features affect strength of these spatial interactions? We quantified the inter-stimulus interval (ISI) over which an unambiguous disparity pattern influenced stereo-matches for patterns with several possible solutions. Likelihood of MRD decreased as ISI increased (48.9 ms time constant) and increased as contrast was reduced for short ISIs, suggesting that monocular persistence (temporal impulse response) underlies the temporal interaction.

Contrast Sensitivity↗

PubMed2003

Eye movements facilitate stereo-slant discrimination when horizontal disparity is noisy.

Conditions in which saccadic gaze shifts within planar surfaces facilitate stereo-slant discrimination for slant about the horizontal and vertical axis were investigated. When horizontal disparity noise was added, large gaze shifts in the direction of the slant lowered stereo-slant discrimination thresholds compared to thresholds measured with steady central fixation, whereas eye movements orthogonal to the slant orientation did not lower slant-discrimination thresholds. When no horizontal noise was added, performance was the same with and without gaze shifts. These results suggest that slant is recovered from depth differences between target edges when horizontal disparity signals are variable and that foveal fixation improves the measures of disparity. Eye movements did not lower slant thresholds by providing multiple foveal samples of slant at different target locations that were averaged to reduce disparity noise levels, because eye movements only lowered the thresholds when there was a depth difference between the fixation points. To study which signals for azimuth are used when slant is recovered from the difference in depth between target edges, vertical disparity noise was added and stimulus height was reduced. Both methods elevated slant-discrimination thresholds when horizontal disparity noise was present, suggesting that vertical disparity is used as a cue for azimuth.

Depth Perception↗

PubMed2003

Thresholds for stereo-slant discrimination between spatially separated targets are influenced mainly by visual and memory factors but not oculomotor instability.

Surface-slant variations can be sensed either simultaneously with steady fixation or sequentially with saccadic gaze shifts. Stereo-slant discrimination thresholds are affected by visual, oculomotor, and memory factors. We have investigated the effects of fixation strategy, target separation, and exposure duration on stereo-slant discrimination. With long exposure durations (734 ms), stereo-slant discrimination thresholds measured with simultaneous presentation of test and reference stimuli were lower with gaze shifts than without them when target separations exceeded 4 deg. Above 4-deg target separations, the benefits of improved disparity resolution with foveal gaze shifts outweighed the costs of oculomotor variability associated with saccades. With short exposure durations (167 ms), as target separation increased, stereo-slant discrimination thresholds measured without gaze shifts increased with both sequential and simultaneous stimulus presentations, whereas thresholds with gaze shifts remained constant. This indicates that oculomotor errors are not an important factor in stereo-slant discrimination. In contrast to stereo-slant thresholds, sequential stereo-depth thresholds between two dots, measured with gaze shifts, increased with target separation. Thus, oculomotor error increases with target separation, and it is an important factor in stereo-depth discrimination.

Depth Perception↗

PubMed2003

Comparison of the time courses of concomitant and nonconcomitant vertical phoria adaptation.

Vertical phoria adaptation was measured before, during, and after 1 h of training with either a prism or magnifying lens. With the prism (concomitant adaptation) a single vertical disparity was presented at primary position. With the magnifier (nonconcomitant adaptation) two vertical disparities of opposite sign were presented along the vertical meridian. Following adaptation, binocular vision was prevented with an eye patch, and vertical phorias were measured periodically along the primary vertical meridian over the course of 8 h. Despite individual variation, adaptation followed approximately exponential time courses. The average time constants for the decay of concomitant and nonconcomitant adaptation were 31 and 83 min, respectively. There was no consistent relationship between the rates of acquisition and decay nor was there a strong relationship between the gains of the adaptive responses and the rates of decay although there was a general trend for the gains of the nonconcomitant responses to be higher and the rate of decay slower than the concomitant responses. The results support the notion that concomitant and nonconcomitant phoria adaptation involve different mechanisms but not the contention that adaptation to prisms is easier or more robust than adaptation to lenses.

Adaptation, Physiological↗

PubMed2002

Changes in cyclotorsion and vertical eye alignment during prolonged monocular occlusion.

When binocular vision is prevented with monocular occlusion, the two eyes assume a position of rest related to the combination of underlying tonic innervation of the oculomotor system, cross-coupled accommodative-vergence input and vergence responses to perceptual cues for spatial location relative to the head. When the latter two are controlled, the covered eye has been shown in the majority of subjects to turn outward (exophoria) and upward (hyperphoria) after prolonged monocular occlusion. The present study investigates the change in torsional eye alignment and its relation to vertical eye alignment after eight hours of monocular occlusion. The results revealed an excyclophoria during occlusion in four out of five subjects. The patched eye also became elevated in two subjects and depressed in two others. Thus, during prolonged monocular occlusion, the relative directions of cyclophoria and vertical phoria appear to be independent. In addition, there were non-concomitant changes in vertical phoria with horizontal gaze, toward a state where the adducted eye was elevated relative to the abducted eye. Simulations with Orbit(TM) suggest that these non-concomitant changes in vertical phoria with a concomitant excyclophoria may be based upon orbital mechanics. Excyclophoria appears to be the baseline state of binocular alignment.

Humans↗

PubMed2002

Adaptive control of vergence in humans.

Vergence eye alignment minimizes horizontal, vertical, and cyclodisparities to optimize stereo-depth perception. Only the horizontal component of vergence is under voluntary control. Couplings with voluntary version and horizontal vergence guide vertical vergence and cyclovergence. Can these couplings be modified in response to sensory demands on binocular vision? We have modified vertical vergence and cyclovergence in response to optical changes in disparity. Vertical vergence was stimulated with aniseikonic lenses that exaggerated vertical disparity in tertiary gaze. Vertical vergence adapted in an hour to produce nonconcomitant changes in vertical phoria that varied with vertical eye position in tertiary gaze. Cyclovergence was stimulated with cyclodisparities that varied with gaze elevation and convergence angle. Cyclovergence adapted within 2 hours to produce nonconcomitant changes in cyclophoria that varied with gaze elevation and convergence. The adaptive couplings for vertical vergence and cyclovergence are modeled as a combination of passive orbital mechanics and active gain control of the vertical recti and obliques. Vergence adaptation is a calibration process that adjusts the innervation for horizontal, vertical, and torsion components of vergence to the physical constraints set by the extraocular muscles and orbital connective tissues. Passive orbital mechanics simplify the neural control for precise vertical vergence and cyclovergence that are needed to achieve binocular alignment under open-loop conditions in response to perceived spatial location.

Adaptation, Physiological↗