Copper and silver wiring in hypertensive retinopathy.
Explore the source record for details and available documents.
Arteriosclerosis↗
Biomedical subjects
Colin Jones
Publications and source records attributed to Colin Jones.
Persistent familial hematuria in children and the locus for thin basement membrane nephropathy.
This study examined how often children with persistent familial hematuria were from families where hematuria segregated with the known genetic locus for the condition known as benign familial hematuria or thin basement membrane nephropathy (TBMN) at COL4A3/COL4A4. Twenty-one unrelated children with persistent familial hematuria as well as their families were studied for segregation of hematuria with haplotypes at the COL4A3/COL4A4 locus for benign familial hematuria and at the COL4A5 locus for X-linked Alport syndrome. Eight families (38%) had hematuria that segregated with COL4A3/COL4A4, and four (19%) had hematuria that segregated with COL4A5. At most, eight of the other nine families could be explained by disease at the COL4A3/COL4A4 locus if de novo mutations, non-penetrant hematuria or coincidental hematuria in unaffected family members was present individually or in combination. This study confirms that persistent familial hematuria is not always linked to COL4A3/COL4A4 (or COL4A5) and suggests the possibility of a further genetic locus for benign familial hematuria. This study also highlights the risk of excluding X-linked Alport syndrome on the basis of the absence of a family history or of kidney failure.
Adolescent↗
Impressions from sea--LMA perspective.
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Delivery of Health Care↗
The pathocenosis moment: Mirko Grmek, the Annales and the vagaries of the longue durée.
Grmek's important article on pathocenosis, which appeared in 1969 in the Annales, did not achieve the fame and significance which it seemed to merit. This needs to be explained not only in terms of Grmek's own history, but also in changes in intellectual fashion, including in the Annales themselves. The work was also eclipsed by W.H. McNeill's best-selling Plagues and Peoples. History's 'cultural turn' since the 1980s has also limited the article's perceived utility. Nevertheless, the value of the concept is underlined by the articles in this collection.
Communicable Diseases↗
Case study: design? Method? Or comprehensive strategy?
As the case study approach gains popularity in nursing research, questions arise with regard to what it exactly is, and where it appears to fit paradigmatically. Is it a method, a design, are such distinctions important? Colin Jones and Christina Lyons review some of the key issues, with specific emphasis on the use of case study within an interpretevist philosophy.
Attitude of Health Personnel↗
Researching the experience of being critically ill: some methodological difficulties.
The experience of being critically ill and being a patient in a critical care unit has attracted considerable research interest in recent years. Evidence of this is apparent in the increasing development of critical care follow-up services in many of our hospitals in the United Kingdom. However, actually conducting research this area can be fraught with difficulties and problems. Research participants may be extremely vulnerable during their recovery, making the methodological considerations crucial, in any study, which aims to explore the experiences of survivors. This paper explores some of the difficulties the researcher can face when researching this area.
Clinical Nursing Research↗
Retinal detachment in cytomegalovirus retinitis: intravenous versus intravitreal therapy.
PURPOSE: To compare the rate of retinal detachment in a group of patients treated with intravitreal ganciclovir to the rate of retinal detachment in a group of patients treated with systemic ganciclovir. METHODS: A retrospective non-randomized comparative case series was conducted. The participants were 186 consecutive patients with cytomegalovirus (CMV) retinitis treated at two centres over the period from June 1990 to May 1997. Of the 186, 133 patients had systemic therapy of whom 113 had intravenous ganciclovir or foscarnet and 20 had oral ganciclovir, and 53 patients had intravitreal induction and maintenance therapy. The main outcome measure was the rate of retinal detachment, which was calculated using person-months-at-risk denominators. The effect measure used in the main comparative analysis was the hazard ratio obtained from multiple regression using the Cox proportional hazards model. RESULTS: Retinal detachment occurred in three of 53 patients in the intravitreal therapy group, one of 20 patients receiving oral maintenance therapy and 21 of 113 patients receiving intravenous maintenance therapy. The risk of retinal detachment with systemic therapy was 14-fold higher than with intravitreal therapy (P < 0.001)and up to fourfold higher with oral maintenance therapy. CONCLUSIONS: Intravitreal therapy offers a significant advantage over systemic therapy in the treatment of CMV retinitis by substantially reducing the risk of CMV-related retinal detachment.
AIDS-Related Opportunistic Infections↗
Life review following critical illness in young men.
Surviving events that have posed a serious threat to life can result in major psychological problems during the recovery period. Younger patients, with years of life ahead of them, are at risk of depression and loss of self-esteem following their ordeal, despite their physical recovery. Traditional forms of counselling and psychotherapy following traumatic events can sometimes carry a stigma and be viewed as 'disease centred'. Reminiscence and life review therapies, used until now, with the elderly, appear to have valuable transferable benefits to younger survivors of critical illness. Life review and reminiscent interventions are holistic and person centred, techniques resonating with the essence of critical care nursing. Life review and reminiscence can be used therapeutically from an early stage to help minimize the negative psychological effects of being critically ill.
Adaptation, Psychological↗
Benefits of narrative therapy: holistic interventions at the end of life.
Clinical experience tells us that the activity of 'putting the house in order' as patients reach the terminal stage in their illness is both a common and legitimate exercise. This process can entail many activities, both physical and emotional. For example, arranging financial affairs, making a will, compiling a living will, organizing their own funeral, completing unfinished emotional business, and perhaps most importantly, pondering the very meaning of life itself. In a continual search to find innovative ways of supporting those who are touched by death and dying, this article will discuss how narrative therapeutic approaches could be helpful in supporting the family of a terminally ill patient who is 'putting the house in order'. Incorporated within this specialist area are perceptions of death and dying, theories of death and dying as well as emotions and the search for meaning. Also under review will be the evidence base for psychotherapeutic interventions, and a review of the narrative therapy approach.
Bereavement↗
Involving NHS service users in teaching advanced clinical skills.
With the development of advanced practice roles in nursing, innovative ways of delivering programmes are continually sought by academic staff working within higher education. This study explores the ways in which NHS service users can be included in education programmes to develop clinical examination skills for nurses. Although small scale and exploratory, this study concluded that NHS service users benefit from making a contribution towards the education of healthcare staff and feel empowered in the process.
Adult↗