Biomedical subjects

Colin McInnes

Publications and source records attributed to Colin McInnes.

3 recordsLinked to original sources

PubMed2002

Orf virus immuno-modulation and the host immune response.

Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.

Animals↗

PubMed2002

Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells.

The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.

Abortion, Spontaneous↗

PubMedDate not supplied

The UK, health and peace-building: the mysterious disappearance of Health as a Bridge for Peace.

The problem of how to build peace in post-conflict societies continues to loom large for governments and development agencies worldwide. This article examines the involvement of the UK development community in the creation of the World Health Organization's 'Health as a Bridge for Peace' (HBP) programme. It argues that the new development policy context brought in by the United Kingdom Labour administration in 1997 appeared to provide fertile ground for health-sector initiatives such as these to become an important part of the UK's peace-building strategy, but that HBP in fact failed to take root. The role of individuals, the changing departmental focus of the Department for International Development (DFID), its relationship with WHO, and the absence of persuasive evidence for the efficacy of HBP are highlighted as being crucial in explaining the policy's mysterious disappearance.

Global Health↗