Biomedical subjects

Cornelis Storm

Publications and source records attributed to Cornelis Storm.

6 recordsLinked to original sources

PubMed2005

Nonlinear elasticity in biological gels.

The mechanical properties of soft biological tissues are essential to their physiological function and cannot easily be duplicated by synthetic materials. Unlike simple polymer gels, many biological materials--including blood vessels, mesentery tissue, lung parenchyma, cornea and blood clots--stiffen as they are strained, thereby preventing large deformations that could threaten tissue integrity. The molecular structures and design principles responsible for this nonlinear elasticity are unknown. Here we report a molecular theory that accounts for strain-stiffening in a range of molecularly distinct gels formed from cytoskeletal and extracellular proteins and that reveals universal stress-strain relations at low to intermediate strains. The input to this theory is the force-extension curve for individual semi-flexible filaments and the assumptions that biological networks composed of these filaments are homogeneous, isotropic, and that they strain uniformly. This theory shows that systems of filamentous proteins arranged in an open crosslinked mesh invariably stiffen at low strains without requiring a specific architecture or multiple elements with different intrinsic stiffness.

Biopolymers↗

PubMed2005

Fast DNA translocation through a solid-state nanopore.

We report experiments and modeling of translocation of double-strand DNA through a siliconoxide nanopore. Long DNA molecules with different lengths ranging from 6500 to 97000 base pairs have been electrophoretically driven through a 10 nm pore. We observe a power-law caling of the translocation time with the length, with an exponent of 1.27. This nonlinear scaling is strikingly different from the well-studied linear behavior observed in similar experiments performed on protein pores. We present a theoretical model where hydrodynamic drag on the ection of the polymer outside the pore is the dominant force counteracting the electrical driving force. We show that this applies to our experiments, and we derive a power-law scaling with an exponent of 1.22, in good agreement with the data.

Computer Simulation↗

PubMed2004

Reply to "Comment on 'Theory of high-force DNA stretching and overstretching' ".

In his Comment to an earlier paper [Phys. Rev. E 67, 051906 (2003)]] Lam points out an error in Eq. (20) of the original paper. Here we show that use of the corrected expression produces results very similar to those presented in our original paper, so our qualitative conclusions are unchanged.

Computer Simulation↗

PubMed2003

Sources and holes in a one-dimensional traveling-wave convection experiment.

We study dynamical behavior of local structures, such as sources and holes, in traveling-wave patterns in a very long (2 m) heated wire convection experiment. The sources undergo a transition from stable coherent behavior to erratic behavior when the driving parameter epsilon is decreased. This transition, as well as the scaling of the average source width in the erratic regime are both qualitatively and quantitatively in accord with earlier theoretical predictions. We also present results for the holes sent out by the erratic sources.

Journal Article↗

PubMed2003

Experimental evidence for an intrinsic route to polymer melt fracture phenomena: a nonlinear instability of viscoelastic Poiseuille flow.

The production rate of polymer fibers by extrusion is usually limited by the appearance of a series of instabilities ("melt fracture") that lead to unwanted undulations of the surface. We present both qualitative and quantitative experimental evidence that-in addition to previously known polymer-specific scenarios-there is an intrinsic route towards melt fracture type phenomena: a nonlinear ("subcritical") instability of viscoelastic Poiseuille flow.

Journal Article↗

PubMed2003

Intrinsic route to melt fracture in polymer extrusion: a weakly nonlinear subcritical instability of viscoelastic poiseuille flow.

As is well known, the extrusion rate of polymers from a cylindrical tube or slit (a "die") is in practice limited by the appearance of "melt fracture" instabilities which give rise to unwanted distortions or even fracture of the extrudate. We present the results of a weakly nonlinear analysis which gives evidence for an intrinsic generic route to melt fracture via a weakly nonlinear subcritical instability of viscoelastic Poiseuille flow. This instability and the onset of associated melt fracture phenomena appear at a well-defined ratio of the elastic stresses to viscous stresses of the polymer solution.

Journal Article↗