PubMed Health⌕ Search

Biomedical subjects

Cristian Didilescu

Publications and source records attributed to Cristian Didilescu.

5 recordsLinked to original sources
PubMed2005

Respiratory pathogens in dental plaque of hospitalized patients with chronic lung diseases.

Bacterial cultivation studies have shown that dental plaque is a reservoir for respiratory pathogens in intensive care unit patients and in elderly who are debilitated, hospitalized or in a nursing home, placing them at risk of bacterial pneumonia. No information is available, however, concerning dental plaque as a reservoir of putative respiratory pathogens in hospitalized patients with chronic lung diseases. Supragingival plaque colonization of 34 hospitalized chronic lung-diseased Romanian citizens, excluding those with tuberculosis and less than 20 teeth, was therefore assessed by checkerboard DNA-DNA hybridization using a selected panel of whole genomic DNA probes produced from eight respiratory pathogens and eight oral pathogens. Thirty-one lung-healthy dental outpatients served as reference population. Respiratory pathogens were detected in plaque from 29 of the 34 (85.3%) hospitalized patients and 12 of the 31 (38.7%) reference population subjects. Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacter cloacae occurred significantly (p<0.05) more frequent among the hospitalized patients. Hospitalized chronic lung-diseased patients harbored in their supragingival plaque samples bacteria known to cause nosocomial pneumonia significantly (p<0.001) more frequent than lung-healthy dental outpatients. Our results indicate that dental plaque in patients with chronic lung diseases often serves as a reservoir of bacteria known to cause nosocomial pneumonia in susceptible individuals.

Adult↗
PubMedDate not supplied

[The tuberculosis endemy in Bucharest, Romania, in 2005].

In Bucharest, TB incidence (new cases + relapses) was 65.9 per thousand in 1985. After that, it increased every year, reaching 154.1 per thousand in 2001. In the last 4 years the incidence decreased to 120 per thousand, meaning a decrease rate of 22% in this interval. In 2005, incidence ranged between 91 per thousand in Sector 1, and 138.7 per thousand in Sector 5. Among all patients registered in 2005, 86.1% were new cases and 13.9% relapses. One noted also a decrease of TB incidence in children, from 65.2 per thousand in 2002 to 27.8 per thousand in 2005. Progressive extension of DOTS in the whole city led to a success rate for "source" patients of 88.7% in 2004 (new pulmonary TB cases, smear positive). The late discovery of some cases and failure of re-treatments explain mainly the fact that, between 2002 and 2004, in Bucharest were registered about 200 TB deaths every year. Tuberculosis continues to be one of the main public health problems in Bucharest.

Adolescent↗
PubMedDate not supplied

[Epidemiology of lung cancer].

This articles aims to review epidemiological aspects related to lung cancer (LC). The risk factors for LC are external factors and host factors. One can note an increasing incidence of LC in women, related to considerable increase of smoking habits in this group. Mortality by LC is related to number of cigarettes smoked daily and how deep the smoke is inhaled. Air pollution and occupational factors increase the LC risk among industrial workers. Pre-existing lung diseases (pulmonary fibrosis, COPD or bronchial asthma) can increase the risk for LC. There are also genetic factors involved in LC. Carcinogenesis is a multi-stage process. In each stage exogenous and endogenous factors are involved, determining mutations on the dominant oncogenes and on genes suppressing tumor appearance.

Age Distribution↗