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Biomedical subjects

Cristina Popescu

Publications and source records attributed to Cristina Popescu.

3 recordsLinked to original sources

[Pathological cataracts in systemic diseases].

PURPOSE: To show the physiopathological mechanisms which determines the appearance of the pathological cataract and types of cataract and clinical manifestations of the systemic disease and operative complications. METHOD: Retrospective study that includes 22 patients hospitalized in clinic with pathological cataract diagnosis, appeared in following systemic disease: diabetes mellitus, skin disease, endocrine disease, SNC disease. RESULTS: Generally the patients had posterior subcapsular cataract or nuclear and posterior subcapsular cataract with fast evolution to intumescent cataract. Phacoemulsification with IOLCP performed at all patients. Good evolution and not surgery complications. CONCLUSIONS: The difficult of the surgery was connected with the risk of the posterior capsular break ( the majority cases were soft cataract) and also connected with the capsulorhexis making in intumescent cataracts. The post surgery evolution was not different compared with a usually cataract.

Adult↗

[Physical and chemical characterization of allantoin-beta-cyclodextrin inclusion complex].

Solubility and bioavailability of poorly water-soluble drugs have been improved by the preparation as cyclodextrin inclusion complexes. The aim of this study is to obtain and characterize the inclusion compound allantoin-beta-cyclodextrin. Allantoin is a vegetable drug, poorly water-soluble (1:300), isolated from roots of Symphytum off. The solid inclusion complex was prepared by mixing with a adequate quantity of water and drying at 50 degrees C to the constant weight. It was used a different proportions between allantoin and beta-cyclodextrin (1:4, 3:7). The inclusion complex was characterized with RMN and IR spectrum and compared with results obtained from beta-cyclodextrin and allantoin alone. The experimental results were demonstrated the inclusion of allantoin in the lipophilic cavity of beta-cyclodextrin without physico-chemical changes.

Allantoin↗