Biomedical subjects

Cynthia E Dunning

Publications and source records attributed to Cynthia E Dunning.

At least 19 recordsLinked to original sources

PubMed2006

The effect of coronoid fractures on elbow kinematics and stability.

BACKGROUND: Coronoid fractures often occur in the setting of more complex elbow trauma. Little is known about the influence of coronoid fracture size on elbow kinematics, particularly in the setting of concomitant ligament injuries. The purpose of this study was to determine the effect of coronoid fractures on elbow kinematics and stability in ligamentously intact and medial collateral ligament deficient elbows and to determine the effect of forearm position on elbow stability in the setting of coronoid fracture. METHODS: Eight cadaveric arms were tested during simulated active dependent elbow motion and gravity-loaded passive elbow motion. Kinematic data were collected from an electromagnetic tracking system. The protocol was performed in ligament origin repaired and medial collateral ligament deficient elbows with radial head arthroplasty. Testing was carried out with the coronoid intact, and with 10% (Type I), 50% (Type II), and 90% (Type III) removed. Varus-valgus angulation of the ulna relative to the humerus and maximum varus-valgus laxity were measured. FINDINGS: With repaired ligament origins and medial collateral ligament deficiency, there was increased varus angulation and increased maximum varus-valgus laxity following simulation of a Type II and Type III coronoid fracture. There was less kinematic change with the forearm in supination than in pronation. INTERPRETATION: Elbow kinematics are altered with increasing coronoid fracture size. Repair of Type II and Type III coronoid fractures as well as lateral ligament repair is recommended where possible. Forearm supination may be considered during rehabilitation following coronoid repair. Valgus elbow positioning should be avoided if the medial collateral ligament is not repaired.

Aged↗

PubMed2006

Direct comparison of kinematic data collected using an electromagnetic tracking system versus a digital optical system.

The purpose of this study was to quantify the dynamic accuracy of kinematics measured by a digital optical motion analysis system in a gait analysis laboratory (capture volume approximately 20m(3)) compared to a standard range direct-current electromagnetic (EM) tracking device (capture volume approximately 1m(3)). This is a subset of a larger effort to establish an appropriate marker set for the optical system to quantify upperlimb kinematics simultaneously with gait, in comparison to previous studies of isolated upperlimb movements that have employed EM tracking devices. Rigid clusters of spherical reflective markers and EM sensors were attached to a mechanical articulator that mimicked three-dimensional joint rotations, similar to the elbow. As the articulator was moved through known ranges of motion (i.e. gold standard), kinematic data were collected simultaneously using both tracking systems. Both systems were tended to underestimate the range of motion; however, the application of post hoc smoothing and least-squares correction algorithms reduced these effects. When smoothing and correction algorithms were used, the magnitude of the mean difference between the gold standard and either the EM or optical system did not exceed 2 degrees for any of the compound motions performed. This level of agreement suggests that the measurements obtained from either system are clinically comparable, provided appropriate smoothing and correction algorithms are employed.

Algorithms↗

PubMed2005

Mechanical properties of cancellous bone of the distal humerus.

BACKGROUND: The objectives of this study were to quantify the indentation strength and modulus of distal humeral cancellous bone, and to identify regional variations. The motivations were to assist in prosthesis development and to optimize screw placement. METHODS: Three consecutive 3mm transverse slices were sectioned from the distal ends of seven fresh-frozen cadaveric specimens. A 3 x 3mm grid was drawn on each slice, providing locations for indentation using a flat cylindrical indenter (diameter=1.6mm) attached to a materials testing machine. The mean indentation modulus and local yield strength were calculated for each site, and pooled into nine anatomically defined regions. FINDINGS: Indentation modulus was found to range from 2.9 to 1041.7 MPa with a mean of 309.8 (242.0)MPa. Local yield strength was found to range from 0.6 to 16.3 MPa, with a mean value of 4.4 (2.5)MPa. The most distal slice had higher modulus values (P<0.05), and the posterior lateral region had lower modulus values (P<0.05). There were no slice or regional differences in strength. INTERPRETATION: The influence of slice depth emphasizes the importance of minimizing the amount of bone removed during prosthetic replacement. Regional variations in indentation modulus suggest that the posterior lateral region should be avoided during fixation of implants or placement of screws. A comparison with proximal tibial cancellous bone properties suggests the distal humerus may carry loads approaching 45% of those at the knee, assuming that bone adapts to stress magnitudes.

Aged↗

PubMed2005

Comparison of distal radioulnar joint reconstructions using an active joint motion simulator.

PURPOSE: Distal radioulnar joint (DRUJ) instability can result in pain and functional disability. Numerous DRUJ reconstructive options have been described with minimal biomechanical analysis. The purpose of this study was to evaluate the ability of 4 well-described DRUJ reconstructions to restore joint kinematics using a dynamic, motion-controlled simulator. METHODS: Eleven cadaveric upper extremities had computer-controlled simulated active forearm rotation. Joint kinematics were quantified by using an electromagnetic tracking system. We compared the passive and simulated active kinematics of the intact, unstable, and reconstructed DRUJ (capsular repair, 2 described radioulnar ligament reconstructions, and a radioulnar tethering procedure). RESULTS: All reconstructions improved significantly the kinematics of the unstable DRUJ. The capsule repair restored simulated active joint kinematics closest to the intact DRUJ. CONCLUSIONS: All 4 reconstructions improved DRUJ stability significantly. The capsule repair most closely matched intact DRUJ kinematics and the radioulnar ligament reconstructions were found to be superior to a radioulnar tethering procedure.

Adult↗

PubMed2005

The effect of radial head fracture size on elbow kinematics and stability.

This study determined the effect of radial head fracture size and ligament injury on elbow kinematics. Eight cadaveric upper extremities were studied in an in vitro elbow simulator. Testing was performed with ligaments intact, with the medial collateral (MCL) or lateral collateral (LCL) ligament detached, and with both the MCL and LCL detached. Thirty degree wedges were sequentially removed from the anterolateral radial head up to 120 degrees . Valgus angulation and external rotation of the ulna relative to the humerus were determined for passive motion, active motion, and pivot shift testing with the arm in a vertical (dependent) orientation. Maximum varus-valgus laxity was calculated from measurements of varus and valgus angulation with the arm in horizontal gravity-loaded positions. No effect of increasing radial head fracture size was observed on valgus angulation during passive and active motion in the dependent position. In supination, external rotation increased with increasing fracture size during passive motion with LCL deficiency and both MCL and LCL deficiency. With intact ligaments, maximum varus-valgus laxity increased with increasing radial head fracture size. With ligament disruption, elbows were grossly unstable, and no effect of increasing radial head fracture size occurred. During pivot shift testing, performed with the ligaments intact, subtle instability was noted after resection of one-third of the radial head. In this in vitro biomechanical study, small subtle effects of radial head fracture size on elbow kinematics and stability were seen in both the ligament intact and ligament deficient elbows. These data suggest that fixation of displaced radial head fractures less than or equal to one-third of the articular diameter may have some biomechanical advantages; however, clinical correlation is required.

Aged↗

PubMed2004

Soft-tissue stabilizers of the distal radioulnar joint: an in vitro kinematic study.

PURPOSE: Distal radioulnar joint (DRUJ) stability is dependent on osseous anatomy, soft-tissue stabilizers, and muscle activity. The relative importance of DRUJ soft-tissue stabilizers remains controversial and has not been examined in the more physiologic setting of simulated muscle loading in the intact specimen. The purpose of this study was to examine the role of static stabilizers on the kinematics of the DRUJ during active simulated motion. METHODS: Twelve cadaveric upper extremities underwent computer-controlled, simulated, active forearm rotation. Joint kinematics were measured in the intact specimen and after sequential sectioning of soft-tissue stabilizers including the dorsal and palmar radioulnar ligaments (RULs) and the triangular fibrocartilage (TFC), dorsal and palmar capsule, ulnocarpal ligaments (UCL), extensor carpi ulnaris (ECU) subsheath, pronator quadratus (PQ), and the interosseous membrane (IOM). RESULTS: After sectioning of soft tissues significant changes in the DRUJ kinematics were observed. With a distal to proximal sectioning sequence significant alterations in kinematics were not identified until sectioning of the IOM; with a proximal to distal sectioning sequence intact DRUJ kinematics were maintained until the final soft-tissue (RULs and TFC) sectioning. CONCLUSIONS: Sectioning of all soft-tissue stabilizers produced significant DRUJ instability and abnormal joint kinematics. The RULs and TFC play a key role in DRUJ kinematics because they can help to maintain normal joint rotation in the absence of all other soft-tissue stabilizers. With the preservation of other soft-tissue stabilizers, however, the RULs and TFC are not essential for the maintenance of normal kinematics of the DRUJ.

Adult↗

PubMed2004

The effect of radial head excision and arthroplasty on elbow kinematics and stability.

BACKGROUND: Radial head fractures are common injuries. Comminuted radial head fractures often are treated with radial head excision with or without radial head arthroplasty. The purpose of the present study was to determine the effect of radial head excision and arthroplasty on the kinematics and stability of elbows with intact and disrupted ligaments. We hypothesized that elbow kinematics and stability would be (1) altered after radial head excision in elbows with intact and disrupted ligaments, (2) restored after radial head arthroplasty in elbows with intact ligaments, and (3) partially restored after radial head arthroplasty in elbows with disrupted ligaments. METHODS: Eight cadaveric upper extremities were studied in an in vitro elbow simulator that employed computer-controlled actuators to govern tendon-loading. Testing was performed in stable, medial collateral ligament-deficient, and lateral collateral ligament-deficient elbows with the radial head intact, with the radial head excised, and after radial head arthroplasty. Valgus angulation and rotational kinematics were determined during passive and simulated active motion with the arm dependent. Maximum varus-valgus laxity was measured with the arm in a gravity-loaded position. RESULTS: In specimens with intact ligaments, elbow kinematics were altered and varus-valgus laxity was increased after radial head excision and both were corrected after radial head arthroplasty. In specimens with disrupted ligaments, elbow kinematics were altered after radial head excision and were similar to those observed in specimens with a native radial head after radial head arthroplasty. Varus-valgus laxity was increased after ligament disruption and was further increased after radial head excision. Varus-valgus laxity was corrected after radial head arthroplasty and ligament repair; however, it was not corrected after radial head arthroplasty without ligament repair. CONCLUSIONS: Radial head excision causes altered elbow kinematics and increased laxity. The kinematics and laxity of stable elbows after radial head arthroplasty are similar to those of elbows with a native radial head. However, radial head arthroplasty alone may be insufficient for the treatment of complex fractures that are associated with damage to the collateral ligaments as arthroplasty alone does not restore stability to elbows with ligament injuries.

Aged↗

PubMed2003

Quantifying translations in the radiohumeral joint: application of a floating axis analysis.

The purpose of this study was to apply the Floating Axis analysis technique to the elbow joint, and to verify its ability to quantify clinically relevant radiohumeral translation in vitro using an electromagnetic tracking device. Of particular interest was the ability to quantify changes in anterior-posterior radial head translation, which is associated with the clinical condition of posterolateral rotatory instability of the elbow. Following the method proposed by Grood and Suntay to determine motions in the knee, an elbow coordinate system with axes representing the flexion-extension axis of the humerus, the long axis of the radius, and their mutual perpendicular, was developed. The algorithm was tested using a mechanical articulator that modeled the Floating Axis approach. Translation errors using this articulator were 0.1+/-0.1mm. The algorithm was applied to kinematic data collected from 12 cadaveric elbows that underwent a pivot shift test prior and subsequent to transection of the lateral collateral ligament. Anterior-posterior radiohumeral translation increased significantly in these elbows following the ligament sectioning (p<0.0001), with the average magnitude of posterior translation increasing from 0.9 to 19.8mm at 90 degrees of flexion. This approach will provide valuable information related to alterations in elbow motion pathways, especially for studies aimed at quantifying changes in joint stability.

Aged↗

PubMed2003

Application of screw displacement axes to quantify elbow instability.

OBJECTIVES: To determine if screw displacement axis patterns describing elbow joint motion: (1) change after ligament transection in vitro; (2) can reflect subtle changes in stability as a function of forearm position; (3) can reflect dynamic stabilization of the ligament insufficient elbow provided by muscle activity.Design. An in vitro kinematic study of eighteen cadaveric specimens tested in a joint simulator. BACKGROUND: In the elbow joint, screw displacement axes have been employed for proper positioning and design of endoprostheses. The effect of instability on screw displacement axes has not been previously reported. METHODS: Passive and simulated active flexion, with the forearm maintained in both pronation and supination, was performed on eighteen intact and ligament insufficient elbows. Instability was produced by transection of the medial collateral or lateral collateral ligament complexes. Kinematics were recorded using an electromagnetic tracking device and analyzed with a repeated measures design. RESULTS: During passive motion, division of either ligament caused deviation of screw displacement axes compared to the intact state (P<0.05). Transection of the medial/lateral collateral ligament generated greater instability with the forearm maintained in pronation/supination compared to supination/pronation (P<0.05). Muscle activation increased stability similar to the intact state (P>0.05). CONCLUSIONS: These results are consistent with observations determined using traditional kinematic descriptors. Screw displacement axes can readily detect changes in stability due to ligament sectioning. RELEVANCE: Clinicians can employ the screw displacement axis technique as a succinct descriptor of motion to readily detect elbow instability.

Aged↗

PubMed2003

The effect of radial head fracture size on radiocapitellar joint stability.

OBJECTIVE: The purpose of this study was to determine the effect of radial head fracture size on radiocapitellar stability. DESIGN: Repeated measures using Instron materials testing machine. BACKGROUND: Radial head fractures are common injuries and controversy exists as to the optimal management of displaced wedge fractures. METHODS: Fractures were simulated in six fresh-frozen cadaveric radiocapitellar joints by removing sequential 20 degree wedges from the anterolateral aspect of each radial head until 140 degrees of the radial head was removed. Decreased shear load at the radial head during joint loading was used as an indicator of decreased stability at the radiocapitellar joint. Using a custom designed jig and employing a compressive joint load of 100 N, the maximum shear load at the radiocapitellar joint was measured at 30, 60, 90 and 120 degrees of elbow flexion. RESULTS: There was no difference in the shear load between the intact specimen and that with a 20 degree wedge removed at all flexion angles (P>0.05). Shear load decreased with each increase in wedge size between 20 and 120 degrees (P<0.05). After 120 degrees, one-third the diameter of the radial head, the shear load was always less than 0.8 N. CONCLUSIONS: This study demonstrated an inverse relationship between radiocapitellar joint stability and radial head fracture size. RELEVANCE: Small radial head fracture fragments are biomechanically significant. Therefore, the use of an arbitrary fragment size as an indication for surgery should be reconsidered, particularly if there is an associated ligamentous injury.

Aged↗

PubMed2003

Influence of the pronator quadratus and supinator muscle load on DRUJ stability.

PURPOSE: To determine the effects of altering the load contributions of the pronator quadratus and supinator muscles on in vitro distal radioulnar joint (DRUJ) stability during pronation and supination and before and after ulnar head excision. METHODS: Multiple pronation trials were conducted with incremental loading of the pronator quadratus relative to the pronator teres muscle; supination trials were similarly conducted with incremental loading of the supinator relative to the biceps muscle. All trials were conducted using an upper-limb apparatus capable of simulating muscle/tendon loading and displacement. Stability measurements included dorsal-volar translations of the radius relative to the ulna and DRUJ diastasis and convergence. RESULTS: Increased pronator quadratus loading did not affect intact DRUJ stability but effects were noted after ulnar head excision when the forearm was positioned between neutral and full pronation. Incremental loading of the supinator muscle did not modify DRUJ stability in the intact or ulnar head excised state. CONCLUSIONS: Pronator quadratus muscle activity aggravates forearm instability after ulnar head excision. Immobilization of the forearm in mid- to full supination should minimize pronator quadratus activity and optimize soft-tissue healing. This information may be useful to develop in vitro muscle-loading scenarios and analytical forearm models.

Aged↗

PubMed2003

Variability and repeatability of the flexion axis at the ulnohumeral joint.

Previous investigations have implemented screw displacement axes (SDAs) to define the elbow flexion axis for proper positioning of dynamic external fixators and endoprostheses. However, results across studies vary, which may be attributed to forearm position (pronation-supination) during elbow motion, or the mode of loading (active/passive) employed to generate flexion. Therefore, the aim of this study was to determine the influence of the flexion mode employed and forearm position on individual variation and repeatability of SDAs throughout elbow flexion. With the forearm pronated, the location of the average SDA was similar whether elbow flexion was generated actively or passively. In contrast, with the forearm supinated, the average SDA was 2.4 degrees and 1.4 degrees more valgus (p<0.001) and internally rotated (p<0.001), respectively, and positioned 1.6 and 0.8 mm further proximally (p=0.002) and anteriorly (p=0.005) relative to the capitellum, respectively, during active compared to passive flexion. During active flexion, the location of the average SDA was independent of forearm position. Conversely, during passive flexion, the average SDA angle was 3.4 degrees and 1.0 degrees more valgus (p<0.001) and internally rotated (p=0.009), respectively, and 1.7 and 0.7 mm more proximal (p<0.001) and anterior (p=0.001) relative to the capitellum, respectively, with the forearm held pronated rather than supinated. SDAs calculated throughout flexion deviated from the average SDA in both orientation and position, demonstrating that elbow flexion behaves similar to a loose hinge joint. These factors suggest that to encompass the location of all SDAs throughout flexion, and therefore properly mimic normal elbow joint motion, an endoprosthesis should be modeled similar to a "loose" rather than "pure" hinge joint. This would allow for dependencies of SDA angulation on forearm position and muscle activation, and slight freedom of movement to account for variances in SDA location. These factors should also be considered during soft-tissue reconstructions.

Adult↗

PubMed2003

Development of a motion-controlled in vitro elbow testing system.

Joint simulators can be used to study motion pathways of a human joint, to investigate changes in joint stability following injury, and to formulate improved reconstructive and rehabilitative procedures. Our objectives were: to develop a laboratory-based, motion-controlled elbow testing apparatus capable of simulating tendon (muscle) loading and displacement in a cadaveric specimen; to describe its performance while testing stable and unstable elbows; and to compare its operation to that of a previously designed load-controlled device. Velocity control of a pneumatic actuator was achieved using a custom-written, closed-loop feedback controller. This actuator was incorporated into an elbow testing system that used additional pneumatic actuators and a combination of motion- and load-control to achieve desired motions. Simulations achieved with this apparatus demonstrated small magnitudes of error in actuator position and highly repeatable flexion pathways with the specimens positioned in vertical, varus, and valgus orientations. The repeatability in motion pathways generated in both a stable and unstable elbow model was equivalent to or better than for similar tests performed using the load-controlled system, and the velocity of the resulting elbow motion was more reproducible.

Biomechanical Phenomena↗

PubMed2003

Patellar position after total knee arthroplasty: influence of femoral component malposition.

Patellar shift, tilt, and rotation were analyzed in 7 cadaveric knee specimens during simulated quadriceps loading, in the intact knee, and after implant reconstruction. Femoral component medialization, lateralization, and external rotation were also investigated. Relative motion of the patella with respect to the femur was measured using an electromagnetic tracking system. The spatial position of the patella did not change with standardized total knee arthroplasty (P <.05). After malpositioning of the femoral component, patellar rotation also did not change (P >.05); however, patellar tilt was altered by femoral component external rotation malposition (P <.05), and patellar shift was affected by all femoral component malpositions (P <.05). The spatial position of the patella relative to the femoral shaft was changed with any femoral component malposition, suggesting that the soft tissues were abnormally tensioned. This could result in subsequent wear on the patellar component and, therefore, early failure.

Arthroplasty, Replacement, Knee↗

PubMed2002

An anthropometric study of the distal ulna: implications for implant design.

Arthroplasty of the distal ulna is frequently used for distal radioulnar joint disorders; however, prosthetic failures are common. An implant replicating the ulna may be advantageous from the viewpoint of joint kinematics, wear, and fixation. The geometry of 40 distal ulnas was quantified by computed tomography scanning and radiography. Ulnar head diameter (16.8 +/- 1.6 mm), canal diameter (8.3 +/- 1.6 mm), eccentricity of the head relative to the shaft (2.5 +/- 1.4 mm), and angle of articulation (176 degrees +/- 29 degrees ) were measured. No correlation was found between the diameters of the ulnar head and intramedullary canal (R(2) = 0.2). A modular head-stem system with an eccentric offset may best reproduce the geometry of the distal ulna.

Adult↗

PubMedDate not supplied

The flat spot of the proximal ulna: a useful anatomic landmark in total elbow arthroplasty.

The relationship between the flat subcutaneous dorsal surface (flat spot) of the ulna and the anatomic flexion axis of the elbow was investigated in 68 cadaveric ulnae. The flat spot and the guiding ridge of the greater sigmoid notch were digitized with an electromagnetic tracking device. The area of the flat spot, as well as its angle with the plane of the greater sigmoid notch, was calculated. The size of the flat spot was variable but was found to be nearly perpendicular to the plane of the greater sigmoid notch (mean, 89.8 degrees +/- 6.5 degrees ). This indicates that the subcutaneous dorsal surface of the proximal ulna is a useful landmark to assist the surgeon intraoperatively to orient the ulnar component axially in total elbow arthroplasty.

Arthroplasty, Replacement↗

PubMedDate not supplied

A biomechanical comparison of four reconstruction techniques for the medial collateral ligament-deficient elbow.

The initial strength of the intact medial collateral ligament (MCL) of the elbow and the strength of 4 reconstruction techniques were compared. Twenty cadaveric upper extremities were mounted in a custom jig with the elbow at 90 degrees , and a pneumatic cyclic valgus loading protocol was used. The mean peak load to failure was 142.5+/-39.4 N for the intact ligaments and 53.0+/-9.5 N for the docking reconstructions, 52.5+/-10.4 N for the EndoButton reconstructions, 41.0+/-16.0 N for the interference screw reconstructions, and 33.3+/-7.1 N for the figure-eight reconstructions. The peak load to failure of the MCL reconstructions was inferior compared with the intact ligament (P<.001). No difference in strength was found between the docking and single-strand medial collateral reconstruction with the use of an EndoButton for ulnar fixation (P>.05, beta=.14). Both of these reconstruction methods were stronger than the interference screw or figure-eight technique (P<.004). The optimal fixation method for a single-strand MCL reconstruction may require improved interference screws or a modified EndoButton procedure.

Bone Screws↗

PubMedDate not supplied

Kinematics and stability of the fractured and implant-reconstructed radial head.

Controversy exists as to the optimal management of radial head fractures. Biomechanical studies have been conducted to quantify elbow stability for simulated wedge fractures, head excision, and head replacement, with and without the integrity of the collateral ligaments. Our in vitro studies have demonstrated that in the ligamentously intact elbow, kinematics and stability are slightly altered with simulated depressed wedge fractures up to 120 degrees of the radial head, markedly altered with head resection, and improved after radial head replacement. Radial head excision decreases elbow stability in the ligament-deficient elbow, and radial head replacement improves stability similar to that of the native radial head. The ligaments have the most marked influence on stability, particularly when the upper limb is positioned such that valgus and varus gravity loads are applied to the elbow. Whereas the radial head acts as a secondary stabilizer to the collateral ligaments with the arm in these positions, its relative role is greater when the arm is in the dependent position and elbow flexion is simulated, particularly in extension. Further studies are needed to elucidate the complex interaction of the radial head with the capitellum, the ulnohumeral joint, and the ligamentous structures for different activities of daily living.

Biomechanical Phenomena↗