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Biomedical subjects

D A Atchison

Publications and source records attributed to D A Atchison.

At least 19 recordsLinked to original sources

Assessment of the accuracy of the crossed-cylinder aberroscope technique.

Simulations of the optics of the Howland crossed-cylinder aberroscope technique show that errors in alignment, data collection, and analysis can lead to unexpected asymmetries of the determined aberrations in a rotationally symmetric system. In particular, coma can be incorrectly indicated. The magnitude of the error in aberration measurement depends on the magnitude of the alignment, data collection, and alignment errors. These findings indicate that the tolerances for setting up the technique and data collection should be analyzed thoroughly before quantitative significance is given to the determined aberration coefficients.

Computer Simulation

Predicting the effects of optical defocus on human contrast sensitivity.

We used diffraction modulation transfer functions and model eyes to predict the effect of defocus on the contrast sensitivity function (CSF) and compared these predictions with previously published experimental data. Using the principle that optically induced changes in the modulation transfer function should be paralleled by identical changes in the CSF, we used the modulation transfer function calculations with the best-focus CSF measurements to predict the defocused CSF. An aberration-free model predicted the effects of defocus well when the CSF was measured with small pupils (e.g., 2 mm) but not with larger pupils (6-8 mm). When the model included average aberrations, prediction of the defocused CSF with large pupils was better but remained inaccurate, failing, in particular, to reflect differences between individual subjects. Inclusion of measured aberrations for individual subjects provided accurate predictions in the shape of the monochromatic CSF of two of three subjects with hyperopic defocus and good predictions of the polychromatic CSF of two subjects with hyperopic defocus. Prediction of the effects of myopic defocus by use of measured individual aberrations of one subject were less successful. Hence a diffraction optics model can provide good predictions of the effects of defocus on the human CSF, given that one has knowledge of the individual ocular aberrations. These predictions are dependent on the quality of the aberration measurements.

Contrast Sensitivity

Influence of Stiles-Crawford effect apodization on spatial visual performance.

The Stiles-Crawford effect is often invoked by vision scientists when predictions of the effects of aberrations and defocus on spatial visual performance are not borne out experimentally. Modeling the Stiles-Crawford effect as an apodization, we investigated the expected influence that it would have on spatial visual performance in the presence of 1-diopter primary spherical aberration at the edge of a 6-mm-diameter centered pupil. The changes in refraction produced by a high Stiles-Crawford effect, according to various criteria, were small at approximately 0.10 diopter. The Stiles-Crawford effect has only a small capability to compensate for defocus and spherical aberration. These results indicate that the Stiles-Crawford effect has little influence on spatial visual performance in the case of centered pupils. We suggest that the faith that has often been placed in the Stiles-Crawford effect to account for discrepancies between experimental results and expected results is not justified, at least for well-centered pupils and Stiles-Crawford effects.

Light

Subjective depth-of-focus of the eye.

An experiment is described in which the subjective depth-of-focus (DOF) of the eye, defined as the range of focusing errors for which the image of the target appears to have the same clarity, contrast, and form as the optimal in-focus image, was measured as a function of the size of high contrast (99%) Snellen Es for 5 trained subjects under cycloplegia. Mean DOF increased by approximately 60% as the size of the letter detail increased from -0.2 to 0.87 log min arc (Snellen equivalent: 6/3.8 to 6/45), although there were considerable intersubject variations. DOF declined with increasing pupil diameter, the mean total DOFs being 0.86, 0.59, and 0.55 D for 2-, 4-, and 6-mm pupils, respectively. In a second experiment, use of low (21%) contrast letters with a 4-mm pupil and 4 subjects marginally increased the DOF (by 0.08 +/- 0.05 D); refraction also shifted in a myopic direction by a mean of 0.15 +/- 0.06 D compared with the high contrast letters. A third experiment with four less-experienced subjects demonstrated the importance of instruction and training in any measurement involving judgment of just-perceptible defocus blur. The clinical implications of the results for measurements of refraction and amplitude of accommodation are discussed.

Accommodation, Ocular

Equivalent power of the crystalline lens of the human eye: comparison of methods of calculation.

We present four methods, with different levels of sophistication and precision, for calculating the refractive power of the ocular lens from its optical structure. The first method uses finite ray tracing but simulates a paraxial ray by using small ray heights. The second method involves a recursive paraxial ray-tracing procedure. The other two methods do not depend on any ray-tracing procedure but use much simpler, approximate equations. In the third method the ray height is assumed not to change within the lens, and in the fourth method the ray path is assumed to be parabolic. The fourth method, but not the third method, can separately calculate the power of the surfaces and the gradient-index lens bulk, which are then used in the three-lens equation to calculate the power of the lens as a whole.

Humans

Pupil size, mean accommodation response and the fluctuations of accommodation.

We wished to determine how pupil size and mean accommodation response level interact to influence the fluctuations of accommodation. A dynamic infra-red optometer was used to record accommodation responses while subjects viewed a steady target at two stimulus levels (1.5 and 3 D) through four pupils (1, 2, 4 and 6 mm). It was found for most subjects that the fluctuations of accommodation increase at higher mean accommodation response levels, and small pupils lead to an increase in the low frequency (but not the high frequency) fluctuations of accommodation. The effects of mean accommodation response are independent of pupil size, and the effects of pupil size are independent of mean response level.

Accommodation, Ocular

Consequences of monocular diplopia for the contrast sensitivity function.

Though the human eye generally creates a single image on the retina, the literature contains many examples showing perceptual monocular diplopia. Previously, monocular diplopia resulting from astigmatic defocus has been demonstrated to cause a notch (local minimum) in the contrast sensitivity function (CSF). We examine Verhoeff's (1900) model which explains how monocular diplopia can occur through an interaction between defocus and common ocular aberrations. From the measured ocular transverse aberration function and from the measured monocular diplopia of three cyclopleged subjects we predicted multiple notches in the CSF with hyperopic spherical defocus. Monochromatic and polychromatic CSF were measured for vertical gratings with best refraction and with simulated myopia and hyperopia. Multiple notches in CSF were observed experimentally. Notches in the polychromatic CSF were smaller and broader than those found in the monochromatic CSF. Our aberration model was successful in predicting notches in the CSF with hyperopic spherical defocus. The implications for clinical measurement of CSF are discussed.

Adult

Monocular diplopia caused by ocular aberrations and hyperopic defocus.

As a single aperture, approximately monofocal optical system, the human eye generally creates a single image on the retina. However, the literature contains many reports of perceptual monocular diplopia. While it is easy to understand how distortion may produce monocular diplopia, its reported high incidence in normal eyes is less easily understood. We examine a model which ascribes monocular diplopia to an interaction between defocus and ocular spherical aberration. Using a psychophysical hyperacuity-based alignment procedure we measured the transverse aberration function in 0.5 mm steps horizontally across the pupil in the eyes of three cyclopleged subjects. Ocular transverse aberration functions were derived with best refraction and with simulated myopia and hyperopia. Monocular diplopia was also measured under the same conditions. All three subjects showed significant, but different, degrees of positive spherical aberration. The measured ocular transverse aberration functions were predictably modified by the hyperopic and myopic defocus. Hyperopic defocus combined with positive (myopic) spherical aberration changes a monotonic transverse aberration function with a single inflection point into a biphasic function with two inflection points. The locations of the inflections predict the presence and magnitude of the perceived diplopia. These experimental results confirm Verhoeff's (1900) hypothesis for the ocular cause of monocular diplopia.

Adult

Spectacle lenses which correct oblique astigmatism at all ocular rotations: investigation of "Merté's' conicoidal surfaces.

Merté (1950) described lens forms that correct oblique astigmatism at all ocular rotations. The front surfaces of all lenses were flat, and the back surfaces were made aspherical as conicoids. Merté did not provide a derivation of his formulae for the appropriate conicoidal surfaces. We show that Merté's formula is correct and describe the nature of appropriate conicoidal back surfaces of spectacle lenses.

Astigmatism

Calculating relative retinal image sizes of eyes.

I derive simple formulas which accurately give the relative retinal image sizes of corrected eyes. These are useful in calculations involving anisometropia and/or refractive surgery. Using the formulas, I derive simple equations for particular situations and provide two examples. I compare the formulas with the approach adopted by Applegate and Howland (1993) and Applegate and Chundra (1995) to determine relative retinal image sizes before and after refractive surgery.

Eyeglasses

Measurement of monochromatic ocular aberrations of human eyes as a function of accommodation by the Howland aberroscope technique.

Further development of the objective version of the Howland and Howland [(1976) Science, 193, 580-582; (1977) Journal of the Optical Society of America, 67, 1508-1518] aberroscope technique for measuring ocular aberrations is described. Compensation for refractive corrections and calibration is discussed. The technique was used to investigate the effect of accommodation upon the monochromatic aberrations of the right eyes of 15 subjects. Coma and coma-like aberrations were the dominant aberrations for most people at different accommodation levels, thus confirming previous findings. Variations in aberrations were considerable between subjects. About half the subjects showed the classical trend towards negative spherical aberration with accommodation. Changes in spherical aberration with accommodation in this study were less than found in previous studies where all monochromatic aberration was considered to be spherical aberration.

Accommodation, Ocular

Monochromatic aberrations and myopia.

The monochromatic aberrations present in the eyes of a group of 21 young myopic subjects and 16 young emmetropic subjects were measured along the visual axis at three levels of accommodation. The aberrations were measured using a modified aberroscope technique which makes use of a retinal camera to photograph the shadow image of the aberroscope grid on the retina, while accommodation levels of 0, 1.5 and 3.0 D were induced consensually. Fourth-order aberrations were significantly different between the emmetropic and myopic groups, with the myopes showing lower fourth-order terms. A high proportion of the aberroscope grids photographed in the myopic eyes were too highly aberrated to permit analysis.

Accommodation, Ocular

Continuous gradient index and shell models of the human lens.

Because of the complexity of tracing rays through a gradient refractive index medium, the human eye's lens is sometimes approximated by a shell structure with constant refractive index within shells. In the shell model, power arises from a combination of an axial variation in index and the curvatures of the shell surfaces. We develop an equation which gives the power due to the gradient index of the lens, and use this to choose shell models that have the same power as the continuous gradient index model. Some types of shell models are described and evaluated.

Humans

Useful variations of the Badal Optometer.

The simple Badal Optometer consists of a movable target and a fixed positive power lens placed at its focal distance away from the eye. The perceived angular size of the target is independent of target position and the power scale is linear. Limitations of the simple Badal Optometer include restriction of negative (myopic) ocular vergence range, the need for targets to be small, and the problem of "proximal" accommodation. We describe two modifications to the Badal system in which these limitations may be overcome by the use of a movable auxiliary optical system. In one modification, the movable auxiliary system consists of a target and positive lens which together may provide a virtual "target" for the Badal lens and thus increase the negative range. In the second modification, the Badal lens is positioned as it would normally be, but the target is an image of a distant stimulus created by the auxiliary lens. The target position (and hence the ocular vergence) is changed by moving the auxiliary lens. The distant target eliminates the proximal accommodative stimulus and allows spatial detail near the resolution limit to be displayed.

Accommodation, Ocular

Aberrations associated with rigid contact lenses.

A rigid contact lens on an eye can produce levels of spherical aberration very different from those produced by a spectacle lens in front of the eye. These levels are considerably affected by contact lens surface asphericity. Change in longitudinal spherical aberration associated with aspherizing a contact lens surface is well predicted by a simple equation for change in sagittal power of the surface. Displacing an aspheric contact lens on the eye can produce considerable defocus, which is well predicted by simple equations for change in sagittal and tangential surface powers. The best refractive correction with contact lenses can be determined only by overrefraction with a patient wearing a contact lens of power and characteristics similar to that which will be prescribed. An aspheric contact lens that moves to a considerable extent on the eye will cause more unstable vision than will a spherical lens that moves to the same extent.

Contact Lenses

Accommodation and presbyopia.

The mechanism of accommodation has been studied for at least four hundred years. The most interesting aspect of accommodation is that its time course is well in advance of other physiological functions--it begins to decline by adolescence and is lost about two-thirds of the way through the normal life span. The state of presbyopia is reached when accommodation has declined sufficiently to interfere with close tasks requiring acute vision. Presbyopia is generally considered to originate with the 'plant' of the accommodative system, either within the lens and its capsule or within their support structures. One of the lenticular theories, the Hess-Gullstrand theory, is distinguished from other theories by its claim that as age increases there is an increasing excess amount of ciliary muscle contraction beyond the ability of the lens and capsule to respond to it. For all other theories, the maximum possible amount of ciliary muscle contraction is always necessary to produce maximum accommodation, at least beyond the age at which it reaches its peak. From my review of the present understanding of the mechanisms of accommodation and the theories of the development of presbyopia, I conclude that there is overwhelming evidence against the Hess-Gullstrand theory and that it is unlikely that changes in the ciliary muscle contractility contribute significantly to the development of presbyopia.

Accommodation, Ocular

Accommodation-convergence relationships and age.

PURPOSE: The objective of this study was to determine if there are differences in accommodative-convergence/accommodation (AC/A) and convergence-accommodation/convergence (CA/C) ratios in subjects with increasing age. The authors aimed to relate the findings to the present theories of the development of presbyopia. METHODS: Using a Canon AutoRef R-1 to measure accommodation and an IRIS eye movement monitor to measure eye movements, the authors determined objective AC/A and CA/C ratios for 23 subjects between 17 and 42 years of age with normal binocular vision. Changes in accommodation and convergence responses were stimulated by lenses (-1.00 DS and -2.00 DS) and prisms (4 and 8 prism diopters), respectively. Measures were made at two visits on consecutive days. RESULTS: A moderate linear relationship was found between AC/A ratio and age (P < .002), and a strong linear relationship was found between CA/C ratio and age (P < .0001). The decrease in CA/C ratio with age was due to a decreased accommodative response to prisms (P = .0001). Measurements were reliable, with 95% confidence intervals at +/- 1.28 delta/D and +/- 0.02 D/delta for AC/A and CA/C ratios, respectively. A reciprocal relationship existed between the AC/A and CA/C ratios. CONCLUSION: The AC/A ratio increases, and the CA/C ratio decreases, in persons between 20 and 40 years of age. This may be because increasing ciliary muscle contraction is required to produce a given change in accommodation with increasing age or because of changes in the adaptability of the tonic accommodation and vergence systems with age.

Accommodation, Ocular