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D A Boudreau

Publications and source records attributed to D A Boudreau.

23 records · Page 2Linked to original sources
PubMed1981

Nine-cell diagnostic decision matrix. A model of the diagnostic process; a framework for evaluating diagnostic protocols.

A nine-cell diagnostic decision matrix is described. This matrix can be viewed dynamically as a model of the diagnostic process. The matrix provides for display of equivocal test results and test results of patients who have ill-defined or incompletely determined disease. The matrix represents an improved model for evaluating diagnostic test protocols. Diagnostic test characteristics related to this model are described. Potential advantages and uses of the model are discussed; among them are possibilities for development of improved diagnostic protocols and improved definitions of disease.

Decision Making↗
PubMed1981

Ranking diagnostic protocols--a proposed process based on use of the nine-cell diagnostic decision matrix.

A process for ranking competing diagnostic protocols for a specific disease is presented. The process incorporates the basic principles of medical decision making, and provides for the consideration of equivocal test results as well as results for patients who have ill-defined or incompletely defined disease. It provides a means for developing an a priori optimization process prior to ranking competing diagnostic algorithms. Methods for transferring ranking information among populations with widely differing disease prevalences are given.

Clinical Laboratory Techniques↗
PubMed1977

CAP interlaboratory survey of analytic balances.

An interlaboratory survey of analytic balances was performed using aluminum oxide spheres weighing about 525 mg each. Results in 82 of the 83 laboratories completing the survey suggest that for this weight level, the error would not exceed +/-0.3% in 19 of 20 weighings; or +/-0.4% in 997 of 1,000. Discussions concerning components contributing to the variance are included.

Analysis of Variance↗
PubMedDate not supplied

Racial comparison of p53 alterations in breast cancer: difference in prognostic value.

A significant difference in breast cancer survival between blacks and whites has been observed in the United States. Biological variation between races has been suggested to explain the difference. We investigated the difference by comparing the prognostic value of p53 alterations (mutations and protein accumulation) between black and white breast cancer patients. Black, but not white, patients with p53 mutations had a significantly poorer survival than those without p53 mutations (p < 0.05). In contrast, white, but not black, patients having tumors with p53 protein accumulation tended to have a poorer survival than those without accumulation of p53 protein (p = 0.058). Among patients who died of breast cancer, blacks were often to have p53 mutations without protein accumulation, and whites frequently had p53 protein accumulation without mutations. The racial disparities in the associations of p53 alterations with breast cancer survival could have clinical implications in terms of treatment management.

Black People↗