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Biomedical subjects

D A Culp

Publications and source records attributed to D A Culp.

At least 37 records · Page 2Linked to original sources
PubMed1981

Experience with germ cell tumors of testicle at University of Iowa.

Between 1964 and 1979, 219 patients with germ cell testicular tumors were treated at the University of Iowa. In 79 nonseminomatous germ cell tumors various chemotherapeutic regimens were used. The response, salvage, and survival rates are compared. There is a definite trend toward better response rates and survival using the combination cisplatinum, vinblastine (Velban), and bleomycin. With this combination, 75 per cent of Stage II and III patients survived two years. The over-all response rate was 85 per cent, and 87 per cent of those with a complete response survived two years. Eighty per cent of deaths occurred within two years and 90 per cent within three years.

Antineoplastic Agents↗
PubMed1981

Percutaneous nephrostomy with immediate dilation.

Percutaneous nephrostomy may serve as an alternative to an open operation for urinary diversion. Difficulties with poor drainage and premature catheter dislodgement have prompted the development of a technique for dilation of the needle tract and placement of a large, self-retaining catheter at the time of the initial puncture.

Adolescent↗
PubMed1981

Urogenital involvement by malignant lymphomas.

Records of 1,068 patients with malignant lymphomas were reviewed from a more than 10-year interval for any evidence of lymphomatous involvement of the urogenital tract. Of the 1,068 patients 72 (6.7 per cent) had urologic findings related to lymphoma either at autopsy, radiographically or at operation. Of 400 cases 23 (5.8 per cent) with Hodgkin's and 49 of 668 cases (7.3 per cent) with non-Hodgkin's lymphoma had some evidence of urogenital involvement at some point in the course of the disease. In the total group reviewed the rate of involvement was low (6.7 per cent) and was essentially equal for patients with Hodgkin's and non-Hodgkin's lymphomas. We herein illustrate various forms of urogenital tract problems encountered in patients with solid lymphatic tumors.

Female↗
PubMed1981

Flutamide in the treatment of metastatic carcinoma of the prostate.

Twenty-five patients with metastatic carcinoma of the prostate were treated with Flutamide, a non-steroidal anti-androgen. All patients showed progression; the longest response was 120 weeks. The side effects were nausea, vomiting, breast tenderness and gynaecomastia.

Aged↗
PubMed1980

Cryotherapy of prostate cancer.

Cryosurgical destruction of primary adenocarcinoma of the prostate was performed via perineal route in 215 patients during a 12-year period. The average age of the patients was 66 years. The stage of the disease varied from stage B to D. In 74% of the patients, no clinical evidence of tumor was found in the prostatic fossa following cryosurgery. Few patients needed transurethral surgery and none needed repeated transurethral resections for obstructive symptoms. This experience suggests that local destruction of prostatic carcinoma can be achieved with little morbidity and mortality. Herein wer discuss the method of cryosurgery, stage and histology or tumor, survival, local recurrence, and complications.

Adenocarcinoma↗
PubMed1980

Serum protein, enzyme and immunoglobulin responses following perineal cryosurgery for carcinoma of the prostate.

Alterations in serum proteins, enzymes and immunoglobulins were analyzed sequentially in 40 patients undergoing perineal cryosurgery for carcinoma of the prostate. A search was made for evidence of a tumor marker and for augmented host response attributable to an immune mechanism. The data showed little evidence to support a systemic immune response. A reliable tumor marker could not be identified when cryosurgery was used alone.

Acid Phosphatase↗
PubMed1980

Penile prostheses for the treatment of impotence.

Eighty-nine patients were treated for impotence with penile prostheses. The Small-Carrion prosthesis was used in 56 patients, the inflatable prosthesis in 27 and Pearman's prosthesis in 6 patients. The overall functional results with the Small-Carrion and inflatable prostheses were comparable.

Adult↗
PubMed1980

Nephrostomy in cancer patients: to do or not to do?

One hundred patients who have had nephrostomies performed for obstructive uropathy in the presence of extensive carcinoma have been retrospectively analysed. Patients with prostatic and cervical carcinoma had a moderately good long-term survival and quality of life, but those with bladder carcinoma or other primary sites had poor results. Significant factors in the selection of patients for nephrostomy drainage in the presence of pelvic cancer are discussed.

Adolescent↗
PubMed1980

Sarcoma of the penis.

Sarcoma of the penis is uncommon. There is no agreed method of management of this tumor. 1 of our patients was cured by radiation therapy.

Adolescent↗
PubMed1979

Blood coagulation following vasectomy.

Concern that men may have an increased risk of the development of thrombophlebitis following vasectomy prompted the study of 58 vasectomized men and 37 age-matched controls. Eight patients undergoing total hip replacement also were studied, since they are known to have an increased risk of thrombotic complications. There were no changes in coagulation suggestive of a thrombotic tendency in the vasectomized population, though an increase in fibrinogen concentration was present preoperatively, and transient increases in factor V concentration, prothrombin time, and fibrinogen concentration were seen postoperatively in some cases. None of the vasectomized patients had clinical evidence suggestive of thrombosis.

Blood Coagulation↗
PubMed1979

Intrascrotal rhabdomyosarcoma.

Rhabdomyosarcoma is the most frequent spermatic cord tumor of infants, children, and young adults, but also occurs as a primary tumor in the testis, epididumis, and testicular tunics. In the last fifteen years, 7 patients with intrascrotal rhabdomyosarcoma were treated at our institution, and an additional 155 cases were found on review of the English literature. On the basis of these 162 cases, incidence and survival statistics were calculated with particular attention to employed forms of therapy. An over-all survival of greater than 73 per cent should be obtainable with proper utilization of surgery, radiation therapy, and combination chemotherapy.

Adolescent↗
PubMed1979

Serum markers in testicular tumors.

Certain cancer-associated substances are useful in the diagnosis and management of cancer. We have found that the estimation of serum alpha-fetoprotein and beta-human chorionic gonadotropin in patients with testicular tumors is useful. Of 17 patients with germ cell testicular tumors found to have elevated serum markers 3 had seminoma of the testis and all 3 had elevated beta-human chorionic gonadotropin. It is not possible, however, to correlate the histology of testicular tumors and the type of serum markers. All of our patients with elevated markers had active tumor. However, 3 patients with metastatic deposits in the para-aortic lymph nodes did not have elevated serum markers.

Chorionic Gonadotropin↗
PubMed1979

Metastatic tumors of the penis.

The penis is a rare site of metastatic neoplasm in spite of its rich blood supply, abundant vascular space, proximity of the pelvic organs and interconnections with the pelvic and vertebral veins as well as lymphatics. The location of primary tumor has varied widely. The urinary bladder, prostate, rectum and rectosigmoid were common primary sites. In our series the bladder was the primary site in 3 patients, prostate in 2, and lung in 1. In 1 patient the metastatic lesion was secondary to lymphoma and in another to leukemia. The mode of metastasis, symptoms, treatment and prognosis are discussed.

Aged↗
PubMed1978

Urinary cytology and bladder biopsy in patients with bladder cancer.

Two hundred fifty patients with bladder tumor were evaluated over a three-year period. Cystoscopy, cytology, and random bladder and tumor biopsy were part of the workup. The follow-up of these patients resulted in a total of 509 cystoscopies, 772 specimens of bladder washings and urinary cytologies, and 503 tumor or selected mucosal biopsies. The value of cytologic study of bladder washings and cystoscopic urine samples as well as the importance of selected site mucosal biopsies in detecting "field changes" in the bladder epithelium associated with bladder tumors are discussed.

Biopsy↗