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Biomedical subjects

D A Dolzhenko

Publications and source records attributed to D A Dolzhenko.

3 recordsLinked to original sources
PubMed1984

[Mechanism of the decrease in intracranial pressure as affected by furosemide].

The correlation was established between the increase in diuresis and natriuresis and fall of CSF pressure after intravenous injection of 10 mg/kg furosemide into dogs. Osmolarity and ion concentration in the serum and CSF did not change in these experiments. In nephrectomized dogs, furosemide did not changes CSF pressure. Furosemide dehydrated brain with traumatic edema, reduced brain Fe content probably due to diminishing brain blood content. The mechanism of intracranial pressure fall after furosemide injection can be explained by acute excretion of a large volume of fluid by the kidneys, leading to a decrease in the blood content of the skull cavity.

Animals↗
PubMed1983

[Effect of furosemide on intracranial pressure in patients with intracranial hypertension].

Furosemid administration to patients with intracranial hypertension of tumour genesis was associated with temporal regression of general cerebral symptoms, coinciding in time with the period marked by a decrease in cerebrospinal fluid pressure. A correlation between the magnitude of this decrease and the furosemid-induced elevated secretion of urine containing chlorine and sodium was established. Restoration of the liquid lost from the body following drug administration was not accompanied by either a fall in the cerebrospinal fluid pressure or a change in the intensity of general cerebral symptoms. The action of furosemid on intracranial pressure is explained by a reduction in the central venous pressure, by an increased outflow of the venous blood from the cranial cavity as well as by its diminished volume. Concomitant administration of large quantities of water lowers or completely precludes the hypotensive action of the agent on intracranial pressure and, thus, is considered unadvisable.

Brain Diseases↗