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Biomedical subjects

D A Enikeev

Publications and source records attributed to D A Enikeev.

At least 19 recordsLinked to original sources
PubMed1992

[Post-intoxication hypothermia and processes of free radical lipid peroxidation in the rat brain and heart in organophosphorus cholinesterase inhibitor poisoning].

The activity of lipid peroxidation (LP) of the brain and myocardium as well as the intensity of the body hypothermia during 30 days after a single introduction of poisons at a dose < D50 were studied on the models of induced toxicosis in rats due to two organophosphorus compounds (malathion and armin). It has been established that the maximums of diene conjugates and Schiff's bases accumulation in the rat organs poisoned with malathion and the intensity of hypothermic response on days 14 and 21 after intoxication coincided. The similar elevated lipid peroxidation was associated with esophageal hypothermia on day 14 after armin administration. Therefore, because of hypothermia, the influence of organophosphorus compounds on lipids of the rat brain and heart in the post-intoxication period may include the free radical ways of their peroxidation.

Animals↗
PubMedDate not supplied

[Effects of presensitization and clinical death in the history on the dynamics of morphofunctional parallels of retinal and cerebral circulation].

A negative effect of preliminary sensibilization with a normal serum and clinical death (restoring to life according to V. A. Negovsky et al.) on cerebral blood supply and eye retina within 5 weeks of postresuscitation period was studied on dogs. Microcirculation disorders in the groups of sensibilized dogs were more prominent as compared to intact animals. The diameter changes of pial and retinal microvessels did not correlate, but qualitative alterations in retinal and cerebral microvessels were of the same type.

Animals↗
PubMedDate not supplied

[The effect of laser hemotherapy on the acid glycosaminoglycan content of the liver and blood plasma in rats in the dynamics of an alcoholic coma].

The aim of the study was determination of the content of acid glycosaminoglicans (GAG) in hepatic tissue and blood plasma of rats in the course of alcoholic coma and in response to laser irradiation of venous blood. The alcoholic intoxication was achieved by introduction of 40% ethanol through a metal probe into the stomach. The content of acid GAG was defined according to Diche. Alcoholic coma caused reduction of GAG levels in hepatic tissue and an increase in blood plasma which were correlated with the severity of neurological state. Laser irradiation of venous blood promoted a trend to normalization of GAG content in the investigated tissues. A relative reduction in GAG plasma levels after laser hemotherapy indicates effectiveness of the conducted therapy.

Alcoholic Intoxication↗
PubMedDate not supplied

[The effect of intravenous laser irradiation of the blood on the brain bioelectrical activity in patients in the postcomatose period].

The article presents clinical data on therapeutic effects of intravenous laser blood irradiation (BI) in severe alcohol intoxication complicated by alcohol coma. BI effectiveness was assessed by EEG changes within 3 postcomatose days. Changes in brain biopotentials in various postcomatose periods were unidirectional. Positive results were achieved after low-intensity laser radiation.

Adolescent↗
PubMedDate not supplied

[Effect of 1,2,4-trimethylbenzene inhalation on energy metabolism in experimental animals].

The authors' investigations show that red cells and tissues of animals exposed to a single 4-h inhalation of vapors of 1,2,4-trimethylbenzene in concentration 10 mg/m3 contained reduced amount of ATP, accumulated amounts of ADP, AMP in active inclusion of 32-P in the structure of these compounds. Activation of ATPase is accompanied with a rise of Na and P concentrations and fall in K, Mg and Ca ions concentrations. In blood plasm there were lower levels of Na and Ca and higher levels of K, Mg and P ions. In exposure to ecotoxicant in concentration 0.01-0.1 and 1.0 mg/m3 the changes were insignificant.

Adenine Nucleotides↗
PubMedDate not supplied

[The lipid peroxidation system in the organism of experimental animals after exposure to cyclic hydrocarbons].

The paper presents the results of studies of the amounts of diene conjugates, malonic dialdehyde, and Schiff's bases, which are molecular LPO products in the tissues of the lung, liver, kidney in animals exposed to 4-hour inhalation of cyclic hydrocarbons (pyromellitic dianhydride, durol, pseudocumene, and dioxane-1,4). Exposure to ecotoxicants at concentrations of 10 and 1 mg/m3 was found to result in the accumulation of initial, intermediate, and final molecular LPO products. These changes were recorded only after exposure to pseudocumene and dioxane vapors in a dose of 0.1 mg/m3 and after inhalation of dioxane-1,4 vapors in a dose of 0.01 mg/m3.

Administration, Inhalation↗
PubMedDate not supplied

[The influence of the actoprotectors on lipid peroxidation and erythrocyte membranes in rats poisoned with malathion ].

Actoprotecting properties ofbemitil, tietasol in combination with atropin were studied in red cell membranes and lipid peroxidation of rats poisoned with MI in a dose 320 mg/kg (0.9 LD50). Atropin treatment showed a low effect. The addition of bemitil and tietasol normalized electric charge and osmotic resistance in red cell membranes, activity of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and content of lipid peroxidation products--ketodienes and TBA-reacting products. Efficacy of the combined treatment is due primarily to noncholinergic mechanism of action of bemitil and tietasol--stimulation of endogenic antioxidant systems of erythron and antiradical activity (bemitil).

Acetates↗
PubMedDate not supplied

[Efficacy of visual information processing in short-term hypoxia].

The effectiveness of visual information processing during short hypoxia modeled by arbitrary external respiratory standstill (AERS) of maximum duration was investigated using our computer program LANDOLT. This program makes it possible to analyze the number of seen, missed, correctly and incorrectly marked signs, all mistakes, the amount and velocity of information processing, to determine the coefficient of accuracy of the task carrying-out. An increase in the amount and velocity of information processing with a less number of mistakes in the experimental group with stronger andlonger hypoxia during AERS can be explained by neuronal influences on the canals of visual information processing from the activating system respiratory center-reticular formation.

Adult↗
PubMedDate not supplied

[Voluntary apnea of maximum duration as a model of short-term asphyxia in psycho- and electrophysiological studies].

We evaluated the test with arbitrary external respiratory standstill (AEKS) of maximum duration as a model of short-term asphyxia. The experiments were carried out in volunteer students. The level of oxyhemoglobin saturation and tissue oxygen tension that we registered in a group of sportsmen in the course of AEKS of maximum duration demonstrated that asphyxia developed in some of the probationers within 100-120 seconds. Taking into consideration the fact that registration of many psychophysiological and electrophysiological parameters takes place within the interval from several hundreds of milliseconds to several tens of seconds AEKS of maximum duration may be regarded as an adequate model of short-term asphyxia.

Adult↗
PubMedDate not supplied

[The mechanisms of the impact of preliminary immunization with staphylococcus anatoxin on postresuscitation pathology of the myocardium].

Chronic experiments lasting for 5 weeks were carried out in 40 nonpedigree mature dogs. It has been detected that preliminary immunization with staphylococcus anatoxin potentiates the compensation mechanisms in the course of postresuscitation period, stimulates cell proliferation by increasing cardiac output that is an adaptive reaction of the cardiovascular system in postresuscitation period and provides optimal metabolism of the organism.

Animals↗
PubMedDate not supplied

[Specified mechanisms of action of preimmunisation with diphtherial anatoxin on myocardial pathology after critical care].

Chronic experiments for 5 weeks made in 41 mongrel adult dogs have shown that prevaccination with diphtheria antitoxin has a negative effect on myocardial and hemodynamic restoration after resustitation. The dogs have arrhythmia, survival of the animals is worse. However, such prevaccination improved survival of the animals due to reduction of reperfusion trauma in animals after hemorrhagic shock in spite of conduction disorders and myocardial ischemia.

Animals↗