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Biomedical subjects

D A Fless

Publications and source records attributed to D A Fless.

8 recordsLinked to original sources

[Effect of hyperbaric oxygenation on animal deaths from acute circulatory disorders caused by intense cerebral excitation].

Sound exposure to 100--120 dB caused death of about 6--16% of white rats KM line from the blood circulation disturbances. The hyperbaric oxygenation (2 atm) decreased the death rate among rats of 4 to 15 months old while having no effect upon younger ones (2--4 months old). The rats who died in hyperbaric oxygenation suffered from O2 intoxication more often than those who survived. Administration of caffeine reduced the positive effect of hyperbaric oxygenation.

Acoustic Stimulation↗

[Influence of convulsive and pre-convulsive components of an audiogenic seizure on the process of consolidation of temporary connections].

In comparing the seizures of different severity in rats an amnestic effect of the convulsive phases of the audiogenic attacks on the short-term (in difference from the long-term) memory and the process of consolidation of temporary associations was revealed. Without behavioristic seizures the audiogenic attacks almost failed to derange the short-term memory. The results obtained confirmed the authors' results obtained earlier on different nature of the convulsive and preconvulsive phases of the motor activity during the audiogenic attack in rats. The preconvulsive phase is regarded only as a peculiar motor aura of the audiogenic attack without any convulsive components.

Acoustic Stimulation↗

[The effect of difenin, valproate and phenobarbital on the development of an epileptiform seizure attack in Krushinskiĭ-Molodkina rats].

The anticonvulsant action of diphenin, sodium valproate, and pentobarbital was studied in Krushinskiĭ-Molodkina (KM) rats subjected to audiogenic seizures. The anticonvulsant effects of the drugs were different and dose-dependent. Valproate in a dose of 120 mg/kg completely eliminated the tonic phase of seizures. Given in a dose of 300 mg/kg it in 50% of cases prevented from the development of the initial seizure stage of motor excitation. The peculiarity of the pentobarbital action consisted in its ability to change the character of motor excitation during sound stimulation from the one-wave reaction for the two-wave.

Acoustic Stimulation↗