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Biomedical subjects

D A Garfield

Publications and source records attributed to D A Garfield.

14 recordsLinked to original sources

Open trial of nefazodone for combat veterans with posttraumatic stress disorder.

Fourteen combat veterans completed a 9-week open trial of nefazodone for treatment of posttraumatic stress disorder (PTSD). Overall PTSD symptoms as measured by the Clinician-Administered PTSD Scale (CAPS) showed a modest but statistically significant decrease with nefazodone treatment. Decreases in CAPS reexperiencing and avoidance, but not hyperarousal symptoms, approached statistical significance. Anxiety decreased significantly, and there were trends toward decreased depression and anger on structured assessments. This study adds to the clinical evidence that nefazodone may be helpful for the management of PTSD symptoms.

Adult↗

Lupron-induced mania.

BACKGROUND: Gonadotropins and sex hormones are intimately related to the stability of affective states. Patients with affective disorders may demonstrate abnormal levels of sex hormones and gonadotropins. It is therefore possible that affective disorder patients may experience mood dysregulation by synthetic sex hormones and gonadotropins like lupron. METHODS: A case report of a young woman with a history of endometriosis and a past history of irritability and depression is described. Treatment of the endometriosis with lupron induced a manic episode. RESULTS: The lupron-induced mania was successfully treated with a mood-stabilizing agent, lithium carbonate. CONCLUSIONS: Patients with a history of affective disorder may develop manic episodes when treated with Lupron. Mood-stabilizing agents are helpful in ameliorating this unwanted effect.

Adult↗

All the king's horses and all the king's men. Three forms of curative audience in the recovery from psychosis.

This essay discusses an overlooked ingredient in the psychotherapy of psychosis which is termed the "curative audience." Central to the equation of psychological selfhood is the evocation of a sense of self by experiences that the patient has with objects in the environment. This essay calls attention to an essential function of this environment, namely, that it provides an audience that makes it possible for these "selfobject" transferences, transference interpretations or new, helpful relational experiences to become significant. In essence, it is argued that a "private experience" without an internal or external audience is not therapeutic in the reassembly of self, especially when the power and intensity to overcome psychotic disintegration is required. The idea that the psychotic patient recompensates not only with the help of a therapist but under the auspices of a third entity, has not been previously discussed. Interestingly, all the schools of psychoanalysis have touched on the role of audience in the healing of patients with both neurosis and psychosis, yet this thread has not been followed into its binding together of subjectivity. Three forms of curative audience can be identified corresponding to the beginning, middle, and end phases of treatment. The role of audience in the reassembly of the self is taking its first form in the initial contact or initial relationship with the other and over time develops into the second form, the therapeutic alliance. In the third form of the curative audience, the establishment of an external selfobject milieu that performs the functions of the curative audience is seen as essential to continued cohesion in the recovery from psychosis. Performative statements exert self-cohering effects and can be seen to have their source in the curative audience. Two clinical vignettes were presented to illustrate these ideas.

Adult↗

Selfobjects in psychosis--the twinship compensation.

Psychoanalysts and psychotherapists who work with psychotic patients often encounter unusual clinical phenomena. In this article, a certain kind of phenomena is described, wherein the patient refers to a body part of the therapist as being owned by the patient. This "body part borrowing" or "merger" can be explained by the classical and object relations schools in terms of part and transitional object concepts. These diagnostic formulations will then guide therapeutic intervention. Newer concepts, from the psychoanalytic school of self psychology, particularly that of the twinship selfobject experience, provide for a more effective intervention in these complex clinical situations. Certain psychotic responses, in these cases, delusional misperceptions, can be viewed as the patient's attempt to stave off empathic rupture and fragmentation. "Body-part borrowing" in the treatment setting thus serves as a twinship selfobject compensation; it attenuates the unbearable affects generated by empathic failure. In this article, we offered clinical vignettes to illustrate these processes in two patients with psychosis and one with neurosis. We then offered various suggestions for clinical intervention based on a selfobject understanding of these phenomena.

Adult↗

Application of artifical intelligence principles to the analysis of "crazy" speech.

Artificial intelligence computer simulation methods can be used to investigate psychotic or "crazy" speech. Here, symbolic reasoning algorithms establish semantic networks that schematize speech. These semantic networks consist of two main structures: case frames and object taxonomies. Node-based reasoning rules apply to object taxonomies and pathway-based reasoning rules apply to case frames. Normal listeners may recognize speech as "crazy talk" based on violations of node- and pathway-based reasoning rules. In this article, three separate segments of schizophrenic speech illustrate violations of these rules. This artificial intelligence approach is compared and contrasted with other neurolinguistic approaches and is discussed as a conceptual link between neurobiological and psychodynamic understandings of psychopathology.

Artificial Intelligence↗

The treatment of paranoid phenomena: the development of the self.

The two main problems of patients suffering from paranoid phenomena are discussed from a treatment perspective. These two problems arising from "having trusted too much" and having lost "ownership of the self" result in the classic projections and loss of initiative commonly seen in paranoid psychopathology. Clinicians must first ward off the patients' projections and help patients work toward a position of "healthy skepticism." This article shows: (1) the specific role of narcissism, its structures and processes, as they contribute to the internal changes needed to achieve this goal; (2) how clinicians can rekindle important sources of initiative and aspiration within the patient. Selfobject relationships, the agency of the ego ideal and the role of the affects of hope and affection, along with such specific interventions as "performative statements," have been offered as helpful tools for clinicians who work with paranoid patients.

Adult↗

Natural language processing in psychiatry. Artificial intelligence technology and psychopathology.

The potential benefit of artificial intelligence (AI) technology as a tool of psychiatry has not been well defined. In this essay, the technology of natural language processing and its position with regard to the two main schools of AI is clearly outlined. Past experiments utilizing AI techniques in understanding psychopathology are reviewed. Natural language processing can automate the analysis of transcripts and can be used in modeling theories of language comprehension. In these ways, it can serve as a tool in testing psychological theories of psychopathology and can be used as an effective tool in empirical research on verbal behavior in psychopathology.

Computer Simulation↗

The order of schizophrenic thought.

Analysis of schizophrenic thought disorder reveals structures and regulatory processes that govern its phenotypic expressions. In particular, the three primary variants of this thought disorder--combinative thinking, drive-dominated thinking, and loss of reality testing--can be viewed in terms of thematic structures. Schizophrenic communication is characterized by an affective rule-governing process that channels information into case-grammar thematic structures. The author elaborates an earlier proposal that transformational grammar subunits should be identified and modeled to schizophrenic thought and explicates the use of these specific structures and processes. He then suggests clinical interventions and future research applications.

Afferent Pathways↗

Paranoia and the ego-ideal: death of a salesman's son.

Since Freud's (1911) explication of the nature of paranoia, much has been written concerning the dynamic underpinnings of the illness but less have been detailed regarding its manifestations structurally. This essay, with its case illustration, attempts to detail the relationship between paranoia and the ego-ideal. Both Blos' (1974) ideas on the negative Oedipus complex and Kohut's (1966) ideas on the developmental line of narcissism prove to be useful ways of linking the clinical picture of paranoia to the psychic structure of the ego-ideal. Both technical aspects of treatment as well as theoretical understandings are explored.

Ego↗

Affect recognition and self-esteem in schizophrenia.

Fifteen male schizophrenic patients between the ages of 18 and 40 were compared with 15 matched control subjects on their performance on the Facial Affect Recognition Task and on the O'Brien-Epstein Sources of Self-Esteem Inventory. As has been previously reported, schizophrenic subjects score significantly lower than normals in the recognition of emotion in the human face, particularly on the 'negative' emotions of anger, fear and disgust. Significant differences were found between groups on self-esteem domains of 'competence' and 'personal power', with normal subjects scoring higher. However, on the self-esteem scale of 'defensive self-enhancement', schizophrenic patients scored higher than the control group. Thus, the schizophrenic patients do not have uniformly lower self-esteem than normals but, rather, specific domains of self-esteem are affected. In addition, a significant negative correlation was found between affect recognition and defensive self-enhancement. The clinical-theoretical implications of working with schizophrenia are discussed in the light of these findings.

Adolescent↗

Multiple sclerosis and affective disorder: 2 case reports of mania with psychosis.

Multiple sclerosis and affective disorder are both diseases that wax and wane as well as have variable clinical symptomatology. Their common co-occurrence has given rise to intense speculation about their etiological and clinical connection. In this paper, 2 case reports and discussions are presented, and a pertinent review of the literature is included concerning the question whether affective symptomatology is the direct result of, a reaction to, or coexistent with, the neurological disease process. The specific cataloguing of affective symptoms with multiple sclerosis is suggested as possibly being helpful in warning clinicians as to the presence of multiple sclerosis. The rhythmicity of both illnesses is briefly discussed in the light of recent literature on circadian rhythms.

Adult↗