Biomedical subjects
D A Grattan
Publications and source records attributed to D A Grattan.
Causes of trauma in broilers.
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Synthesis and preliminary pharmacological evaluation of asymmetric chloroquine analogues.
Asymmetric chloroquine analogues (1-4) were prepared of known absolute configuration in order to assess stereochemical influences on selected biological activities. Since chloroquine has been shown to possess spasmolytic properties, analogues 1-4 were tested for similar pharmacological effects on smooth-muscle contraction. The (S)- and (R)-chlorochloroquine enantiomers (1 and 2, respectively) were more potent antispasmodics than the less lipophilic (S)- and (R)-hydroxychloroquines (3 and 4, respectively) when tested against KCl- or acetylcholine-induced contractions of the isolated mouse ileum. A membrane stabilizing mechanism of action for the chloroquine analogues is proposed since neither cellular toxicity nor calcium antagonism plays a role in the spasmolytic action of these compounds. Although compounds 1-4 also inhibited PGF2 alpha-induced contractions of the ileum, 1 was significantly more potent than 2; the latter in turn was equipotent to 3 and 4. It is tentatively proposed that 1 may possess stereoselective affinity for the PGF2 alpha receptor in the ileum. This observation may be further exploited to obtain more selective profiles of biological activity through molecular manipulation.
The eradication of Arizona 7: 1, 7, 8 from a turkey breeding flock.
Day old turkey poults (the F generation) were imported from the USA into the UK and in 1968 young turkey poults of one hatch (F1 generation) showed clinical signs and lesions of arizona infection and serotype 7: 1, 7, 8 was isolated from stock of both generations. After the F3 generation, the flock was dispersed to several large breeders but there seems to have been no evidence of arizona infection in the subsequent five generations of progeny.
Infectious bronchitis in poultry: the use of live vaccines.
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Infectious bronchitis in laying fowls.
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