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Biomedical subjects

D A Hardy

Publications and source records attributed to D A Hardy.

At least 19 recordsLinked to original sources
PubMed2000

Use of famciclovir for the treatment of endotheliotrophic herpesvirus infections in Asian elephants (Elephas maximus).

Two juvenile Asian elephants (Elephas maximus) presented with an acute onset of facial edema and lethargy. Examination of the oral cavity of each animal revealed cyanosis of the tip and distal margins of the tongue suggestive of endothelial inclusion body disease (EIBD) of elephants. Whole-blood samples were obtained, and polymerase chain reaction tests confirmed the presence of elephant herpesvirus. The animals were administered famciclovir (Famvir, SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania 19101, USA), a potent human anti-herpesvirus drug, in the course of their disease, and recovery followed a treatment regime of 3-4 wk. These are the first known cases of elephants surviving EIBD.

2-Aminopurine↗
PubMed1994

Excitement in an elephant after intravenous administration of atropine.

A 28-year-old Asian elephant (Elephas maximus) was anesthetized for cesarean section to remove a dead calf. The elephant was sedated with azaperone, and atropine was administered IV 90 minutes later in preparation for induction of anesthesia with etorphine HCl. Within 1 minute of injection of atropine, the elephant began swaying, kicking, and moving in an agitated manner around the stall. There is considerable variation among species in the toxicity of atropine, although development of toxicosis usually is associated with overdosage.

Anesthesia↗
PubMed1994

Olfactory neuroblastoma invading the oral cavity in a patient with inappropriate antidiuretic hormone secretion.

Olfactory neuroblastoma is an uncommon intranasal neoplasm that has not been previously documented to invade the oral cavity. The tumor's variable clinical manifestations and microscopic features may create a diagnostic dilemma for the clinician. The neoplasm has been identified as a direct cause of ectopic arginine vasopressin production leading to inappropriate antidiuretic hormone secretion. An unusual case of olfactory neuroblastoma invading the oral cavity through the maxillary sinus in a patient with pathologic antidiuretic hormone secretion is reported.

Aged↗
PubMed1990

Use of polymerase chain reaction for successful identification of asymptomatic genital infection with herpes simplex virus in pregnant women at delivery.

The polymerase chain reaction was adapted to the amplification of a herpes simplex virus (HSV) DNA sequence, common to HSV types 1 and 2 (HSV-1, HSV-2). The amplified product was detectable by ethidium-bromide staining or Southern hybridization of gels and by dot hybridization. The HSV polymerase chain reaction detected HSV DNA in samples obtained from eight patients with genital lesions from which HSV-2 was isolated in tissue culture and from four patients with labial lesions from which HSV-1 was isolated. The HSV polymerase chain reaction identified HSV in clinical specimens obtained from 11 women who had asymptomatic genital HSV infections at delivery. None of 11 samples obtained at delivery from women who had antibodies to HSV-2, but whose delivery cultures were negative, were positive by polymerase chain reaction and no false-positive reactions were obtained when the reaction mixture contained human cell DNA or varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, or human papillomavirus DNA.

Blotting, Southern↗
PubMed1987

Osteoid osteomata of the distal phalanx.

Osteoid osteomata are rarely found in the distal phalanges of the hand. The 23 cases in the English language literature are discussed and two additional cases are described. The usual presenting features are chronic pain, nail enlargement and increase in size of the terminal part of the digit. Diagnosis is difficult but surgical excision is effective for treating the patients' pain.

Adult↗
PubMed1975

Intermittent catheterization in children.

Many children with myelodysplasia are ideal candidates for intermittent nonsterile urethral catheterization to manage urinary incontinence. This method of urinary management becomes no permanent commitment and is preferred by patients and parents to supravesical diversion when successful.

Adolescent↗