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D A Hillman

Publications and source records attributed to D A Hillman.

11 recordsLinked to original sources
PubMed1979

HLA-D--related (DRw) antigens in juvenile diabetes mellitus.

We studied the distribution of HLA-D--related (DRw) antigens in 40 patients with juvenile diabetes mellitus (JDM) and 79 matched controls. We found that DRw2 was significantly decreased in the JDM group, suggesting a protective effect of the antigen and that the decrease observed in B7 was secondary. HLA-DRw3 and HLA-DRw4 were increased in the diabetic group, and, as with B8/B15, these two antigen predisposed to the disease additively. The susceptibility for JDM was found to be more strongly related to HLA-DRw3 that to B8. On the other hand, B15 rather than DRw4 showed the stronger association with JDM. Moreover, we found that this second diabetogenic gene is associated primarily with B15 and only secondarily with Cw3, which is in linkage disequilibrium with B15. This study further emphasizes the immunogenetic heterogeneity of JDM.

Diabetes Mellitus, Type 1↗
PubMed1970

Boric acid poisoning.

Explore the source record for details and available documents.

Anti-Infective Agents, Local↗
PubMed1966

Toxic epidermal necrolysis: the scalded skin syndrome.

Toxic epidermal necrolysis is a condition that may occur in all age groups and resembles skin scalding. It presents as a generalized, markedly tender erythema and rapidly progresses to bullous desquamation of the superficial epidermal layers and systemic toxicity.The condition was first described in 1956. A review of the recent literature suggests that the incidence of the syndrome is increasing or it is being recognized more frequently. Its etiology has not been established, but it may represent unusual hypersensitivity to drug, bacterial, viral or immunization factors. The mortality rate in reported cases is approximately 30% and young children and debilitated adults are at greatest risk.Recently, two children with this condition were successfully treated at the Montreal Children's Hospital, using protective isolation, intensive nursing care, intravenous antibiotics and hydrocortisone hemisuccinate. Early use of corticosteroids may inhibit the progression of epidermal necrolysis and improve the prognosis.

Antigen-Antibody Reactions↗