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Biomedical subjects

D A Hudson

Publications and source records attributed to D A Hudson.

At least 55 records · Page 3Linked to original sources
PubMed1999

Are children with clefts underweight for age at the time of primary surgery?

Children with clefts, especially those with a cleft palate, have an impaired sucking mechanism and are therefore prone to nutritional problems. This study was undertaken to determine whether children with clefts of the lip and/or palate are underweight for age at the time of primary surgery. Underweight for age was defined as being less than 80 percent of expected weight for age or below the 3rd percentile as plotted on standard percentile charts. The records of all children with clefts seen at the Red Cross Children's Hospital between 1976 and 1996 were reviewed. Of these 740 records, 100 were excluded for inadequate data (47), severe systemic syndrome (27), no operation done (22), or craniofacial cleft (4). The records of 640 children were thus included; 195 (30.5 percent) were underweight for age. By comparison, only 13.7 percent of a similar group of noncleft controls (n = 872) were underweight for age. The difference between these two groups was highly significant (p < 0.01). Factors that influenced weight at the time of primary surgery were type of cleft and age at the time of surgery. Children with cleft palate, whether associated with a cleft lip or not, were found to be more underweight for age than those with an isolated unilateral cleft lip (p = 0.008). Children who had surgery after the age of 1 year were 1.5 times more likely to be underweight for age than children who had surgery under 1 year of age (p < 0.01). Children with isolated cleft palates who were underweight for age had a tendency toward a higher fistula rate (36 percent) than those of normal weight (24 percent) (p = 0.18).

Body Weight↗
PubMed1999

Repeat reduction mammaplasty.

Repeat reduction mammaplasty is an uncommonly performed procedure. Currently, no clear operative guidelines of management exist. Sixteen patients (28 breasts) with a mean age of 29 years (range, 13 to 52 years) underwent repeat breast reduction over an 11-year period. Before the first reduction, the mean notch to nipple distance was 29.6 cm (range, 24 to 38 cm) and mean nipple to inframammary crease distance was 15.5 cm (range, 12 to 18 cm). The mean mass of tissue excised was 615 g per breast. A number of different pedicles were used (six inferior, five superior, four superomedial, one unknown). All patients subsequently developed pseudoptosis. The nipple to inframammary crease distance was a mean of 11.4 cm (having initially been set at 7 cm) before the second procedure. At the second operation, two patients (three breasts) had their initial pedicles transected and the nipple-areola complex moved, and both patients developed vascular compromise of the nipple-areola complex (two breasts). Where the same pedicle was used in the second operation (five patients, 10 breasts), one patient developed unilateral nipple-areola complex necrosis. In eight patients, because of the development of pseudoptosis, the nipple was in a satisfactory position, and therefore only an inferior wedge of tissue required excision. This was performed without nipple-areola complex compromise, irrespective of the initial pedicle. The mean mass of tissue excised in the second operation was 325 g per breast (range, 120 to 620 g). Fourteen patients were available for follow-up after a mean of 5.1 years (range, 3 months to 11.7 years) following the repeat reduction mammaplasty. In the repeat breast reduction, where nipple-areola complex transposition is planned, the initial pedicle should be reused to maintain nipple-areola complex perfusion. Where the initial pedicle is not known, a free nipple graft may be the safest option. In patients with pseudoptosis, in whom the nipple does not require transposition, an inferior wedge of tissue can be safely excised, irrespective of the initial pedicle.

Adult↗
PubMed1999

Acral dermatofibrosarcoma protuberans with metastases.

Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous tumor that occurs rarely on the extremities. This tumor has a particular propensity for local recurrence following seemingly adequate excision. Metastases are rare, and usually follow repeated local recurrences. On rare occasions, fibrosarcomatous change may arise in a DFSP, and appears to affect adversely the prognosis. The adequacy of the initial resection is the most important prognostic factor; however, suggested margins vary between 1.5 and 5 cm. The ideal margin of resection on the foot is unknown. We report a patient with recurrent, acral DFSP with fibrosarcomatous change and pulmonary parenchymal metastases in a 48-year-old black male.

Dermatofibrosarcoma↗
PubMed1998

Aeromonas hydrophila in burn patients.

Burn wound infection with Aeromonas hydrophila appears to be very uncommon. This study reports on nine cases of A. hydrophila in burn patients treated over a 21 month period at the New Somerset Hospital Burn Unit. The average age of the patients was 31 years (range 24-60 years) and the average TBSA was 33% (range 16-51%). All patients had positive wound cultures for A. hydrophila, obtained on admission or shortly thereafter. One patient also had a positive blood culture. Two patients with small partial thickness burns did not receive antibiotic therapy, and made an uneventful recovery with topical therapy alone. The other seven patients developed clinical signs of septicaemia and required parenteral antibiotics, in addition to topical therapy. One patient died of ARDS, but the other eight recovered and were discharged. No patient had evidence of myonecrosis. Small, superficial burns which culture A. hydrophila can be treated by topical therapy alone. Large and/or deep burns, require antibiotic therapy and debridement of all necrotic tissue, particularly when myonecrosis is present. The antibiotics of choice are the aminoglycosides or the quinolones.

Adult↗
PubMed1998

The clinical significance of c-myc oncogene expression in melanomas of the scalp.

Melanomas of the scalp are rare and have a poorer prognosis than melanomas arising at other cutaneous sites. In order to study the biology of this disease, the activity of the c-myc oncogene was studied in tumours from 25 patients with scalp melanoma using the technique of flow cytometry. Survival analysis revealed that stratification of patients according to oncogene activity provided a prognostic marker with shorter overall survival (log rank test, chi 2 = 3.9, P = 0.05) in tumours with high nuclear c-myc oncoprotein positivity. These results support our previous studies of the prognostic value of c-myc expression in melanoma and suggest that estimation of c-myc oncoprotein may be of clinical significance in identifying high risk patients.

Adult↗
PubMed1998

Melanoma of the face: the safety of narrow excision margins.

Recent studies have shown that narrower excision margins may be safe, but the optimal or minimum margin for melanoma is unknown. Wide margins of excision are possible on the trunk and limbs, but functional and cosmetic constraints often limit the extent of excision on the face. A collaborative study from two continents (Cape Town, South Africa and Northwood, England) investigated the outcome of different excision margins of 106 patients with stage I melanoma of the face. The margin of excision was measured from the records of the pathological specimen. Thirty patients had margins of less than 1 cm, 64 had margins of between 1 and 2 cm, and 12 had margins greater than 2 cm. Primary apposition or flap closure was possible in 85 patients. Seven patients developed local recurrences and these were not influenced by the excision margin. This study supports the contention that the primary treatment of cutaneous melanoma on the face should be histologically confirmed complete excision, and that this can be achieved with margins of excision less than 1 cm. Local recurrence is not related to the margin of excision or to tumour thickness.

Adult↗
PubMed1998

A modified method of continuous venous anastomosis in microsurgery.

The continuous suture technique for end-to-end vascular anastomosis is cautioned against because of the risk of vessel constriction. A modified method of continuous suture for end-to-end venous microanastomosis is presented in which vessel constriction does not occur. This technique was compared with the conventional interrupted suture technique in the rat femoral vein, with each rat serving as its own control. Forty-eight Long-Evans rats were used. The mean time taken to complete the anastomosis was 9.8 minutes (range, 8-14 minutes) for the modified continuous technique and 17.7 minutes (range, 14-24 minutes) for the conventional interrupted technique (p < 0.05, independent t-test). In addition, the veins were examined under the microscope for patency and the milk test was performed on each anastomosis 30 minutes postanastomosis, and 1 week and 1 month postoperatively. Two groups of rats were sacrificed, one at 1 week and one at 1 month, and the two different anastomoses were compared using vessel morphometry in 40 rats and corrosion casts in 8 rats. All veins were patent postoperatively, as well as at 1 week and 1 month postoperatively. Vessel morphometry confirmed a similar luminal surface area in all veins examined at 1 week and 1 month. A two-way analysis of variance of vessel morphometry indicated no significant interaction between the methods used and the postoperative time (p = 0.60). The modified continuous technique is twice as quick as the conventional interrupted technique for end-to-end microvenous anastomosis and does not lead to vessel constriction.

Analysis of Variance↗
PubMed1998

Repair of unilateral cleft lip: a comparison of five techniques.

Repair of unilateral cleft lip is a challenging procedure with no single technique satisfactory for all types of unilateral cleft deformity. This study compares retrospectively five techniques of unilateral cleft lip repair in 72 children (45 boys, 27 girls). Twenty-two children had a Millard rotation-advancement repair, 5 children had a Davies Z-plasty, 22 had a modified Z-plasty, 10 had a Tennison-Randall triangular flap repair, and 13 had a Nakajima-Yoshimura straight-line repair. Assessment was performed clinically by a plastic surgeon not involved in the original surgery. Repairs were assessed objectively by measurement of the vertical length of both the repaired and normal sides of the lip with calipers. Subjective criteria used to evaluate the repair were the symmetry of Cupid's bow, the quality of scar, the alignment of white roll, the evenness of the vermilion, and the lip pout. The mean follow-up period was 5.4 years (range, 9 months-29 years). Sixty-five of the 72 repairs measured (90%) were within two standard deviations (SDs) of normal and thus were considered to be of "acceptable" length. Seven repairs were unacceptably short (>2 SDs) on measurement, six of which included a rotation-advancement repair for a complete cleft lip. Subjective results paralleled the objective results. The outcome following repair of unilateral cleft lip was similar for all five surgical methods assessed except for complete cleft lips repaired by the rotation-advancement technique, which tended to result in an unacceptably short lip as measured on the repaired side.

Adolescent↗
PubMed1998

The burnt male--intentional assault on the male by his partner.

There are few studies which address the burnt male patient who has been intentionally assaulted by his partner. Thirty such patients were admitted to the Somerset Hospital Burns Unit between January 1993 and May 1995. The average age was 37 years and the mean total burn surface area was 19.6% (range 2-55%). A variety of agents had been used to inflict the burn, but throwing hot fluid at the victim was the most common. The head, neck and chest were the most common areas burnt. Five patients developed respiratory burns and 2 required ventilatory support. Three patients died: 1 of respiratory failure and 1 of septicaemia, while 1 committed suicide. The burnt and battered male patient is a real clinical entity which is becoming more common. Treatment should investigate psychosocial factors in addition to ensuring healing of the burn wound.

Adult↗
PubMed1998

Trigger thumb in children--results of simple surgical treatment.

The effectiveness of simple surgical release of trigger thumb/finger in children was assessed and the onset of this condition relative to age was investigated in a retrospective study between 1977 and 1992. Referrals to the congenital hand clinic at Red Cross War Memorial Children's Hospital, Cape Town, were studied. A total of 53 children (68 digits) with a mean age of 1.9 years were treated during this period (as day cases). The thumb was involved in 60 digits and involvement was bilateral in 11 children. Symptoms had been present since birth in 43 children. In 51 children (96%) the trigger digit was released successfully; the 2 recurrences were due to inadequate surgical release. Trigger digit in children appears to be a congenital condition. Simple surgical release is effective treatment and can be performed on an ambulant basis.

Child↗
PubMed1998

Plantar melanoma: results of treatment in three population groups.

BACKGROUND: The frequency of plantar melanoma varies widely in different population groups. The plantar surface is an infrequent site in white persons but is common in the black population. The effect of ethnicity on melanoma of the plantar surface has not previously been well defined. The aim of this study was to analyze the results of a standard protocol of treatment of melanoma of the sole in 3 homogeneous population groups treated during a 15-year period at a university referral hospital. METHODS: A retrospective analysis of 1403 consecutive patients with melanoma treated between 1977 and 1991 was performed. Eighty-five patients (35 black, 25 white, and 16 of mixed ancestry) had primary cutaneous melanoma involving the sole of the foot. RESULTS: Acral lentiginous melanoma was the most common histogenetic type and occurred in 49 patients. Significantly more black patients (20 of 35) had metastatic disease compared with white patients or groups with mixed ancestry (P < .05). The Breslow depth was significantly more advanced in black patients (7.1 mm) with stage I disease than in white patients (3.3 mm) or those of mixed ancestry (3.6 mm) (P < .05). The 5-year survival rate was 60% for white patients, 26% for black patients, and 24% for those of mixed ancestry. CONCLUSIONS: Black patients were seen more frequently with advanced local disease, and nearly half had disseminated disease. Those of mixed ancestry had a histogenetic type resembling that of black patients, but the Breslow depth of penetration was similar to that of white patients. Education programs to heighten awareness of both patient and physician are required to enable earlier diagnosis and improve outcome.

Adult↗
PubMed1997

The clinical significance of oncogene expression in subungual melanoma.

Subungual melanoma is a particularly aggressive tumour. However, biological investigations of its behaviour are presently lacking due to its comparative rarity. In order to study the biology of this disease, the activity of the c-myc oncogene was studied in tumours from 24 patients with subungual melanoma using the technique of flow cytometry. High levels of oncoprotein were found in all tumours and exceeded that documented in other varieties of cutaneous melanoma. Survival analysis revealed that stratification of patients according to oncogene activity provided a useful prognostic marker with shorter disease free interval (log rank test, chi 2 = 6.6, P = 0.01) and overall survival (log rank test, chi 2 = 3.6, P = 0.07) in tumours with high oncoprotein levels. This is the first study to investigate oncogene expression in subungual disease and supports its potential application as a prognostic marker.

Adult↗
PubMed1997

Primary epineural repair of the median nerve in children.

We report 18 children (12 boys and six girls) with a mean age of 6.1 years who sustained lacerations of the median nerve. Associated injuries to other structures occurred in 15 children. Treatment was by primary epineural repair. All the children were assessed at least 1 year after injury. The mean return of motor power to the opponens pollicis was 4.5 with a range of 3 to 5 (MRC scale) and the mean static 2-point discrimination was 5 mm (range 2-10 mm). All children showed a full functional recovery as assessed by the Bruininks-Oseretsky test. Primary epineurial repair in children leads to very satisfactory motor and sensory results. A fully functional hand can be expected.

Adolescent↗
PubMed1997

Shack fires: a consequence of urban migration.

Shack fire burns are the second most common reason for admission of patients to the burns unit in Cape Town. A retrospective analysis of 99 patients between January 1993 and June 1995 was undertaken to investigate the demographics and mortality associated with shack fire burns. There were 58 males and 41 females with an average age of 34 years (range 13-17 years). The average total burn surface area (TBSA) was 31 per cent (range 3-98 per cent) and in 67 of these patients a full-thickness component to the burn was noted. The upper limbs and head and neck were the most commonly burnt areas. Inhalation injury affected 61 patients, 18 of whom required admission to an intensive care unit for assisted ventilation due to respiratory failure. Thirty nine patients (39.4 per cent) died. Shack burns are a specific entity associated with significant morbidity and a high mortality. The injuries had a major impact on the victim's life and prevention is the best form of treatment.

Adolescent↗
PubMed1997

Fatal rhabdomyolysis in a flame burn patient.

Rhabdomyolysis due to flame burns is not well described. A case of fatal rhabdomyolysis in an epileptic patient who sustained 65 per cent body surface area, very deep, flame burns is described. It appears as if the sustained muscle compression from the restrictive, circumferential eschar was the major factor in the aetiology of the rhabdomyolysis. Despite aggressive fluid management, the patient died of acute renal failure and adult respiratory distress syndrome. We have subsequently identified three other cases of pigmenturia occurring following burns. It would seem as if rhabdomyolysis following extensive full thickness burns may be more common than previously suggested. Fluid requirements are in excess of those proposed by traditional protocols. Rhabdomyolysis in flame burn patients indicates a poor prognosis.

Accidents, Home↗
PubMed1997

Cancrum oris--a 35-year retrospective study.

OBJECTIVES: To determine the factors predisposing to cancrum oris and its frequency, clinical features, treatment and outcome. Cancrum oris is a gangrenous condition of the face usually occurring in poorly nourished children in a Third-World setting. DESIGN: Retrospective review of clinical data on children with cancrum oris. SETTING: All children with cancrum oris seen over a 35-year period, from 1960 to 1995, at Red Cross War Memorial Children's Hospital (RXH) in Cape Town. SUBJECTS: Twenty-six patients (16 female and 10 male) with cancrum oris. Their average age at presentation was 4 years and 4 months (range 1-15 years). RESULTS: The peak incidence was between 1971 and 1975 (11 cases); subsequently only 1 new case was seen at RXH in every 5-year period. Most children were referred from rural areas. Associated conditions could only be determined in 11 of the 26 patients. In order of frequency, these were malnutrition, gastro-enteritis, measles and anaemia. Twenty-three of the 26 children had soft-tissue involvement affecting the lips, cheek, chin, nose or other structures. Eighteen had bony or cartilaginous involvement; the maxilla was affected in 15, the palate in 7, the vomer in 5, the mandible in 3 and the nasal septum in 7. Three children had bony involvement only, the soft tissues being spared. Operative records were available for 18 children. These 18 children had a total of 84 operations, with an average of 4.7 per child (range 0-12). CONCLUSIONS: Cancrum oris is a devastating condition affecting malnourished children. Reconstruction is complex and demanding, involving both soft tissue (23 of 26 cases) and bone (18 of 26 cases). Most children require multiple procedures. Prevention is best effected by comprehensive primary health care.

Adolescent↗