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Biomedical subjects

D A Ingram

Publications and source records attributed to D A Ingram.

44 records · Page 3Linked to original sources
PubMed1985

The effect of continuous voluntary activation on neuromuscular transmission: a SFEMG study of myasthenia gravis and anterior horn cell disorders.

In normal subjects the neuromuscular jitter does not increase during continuous voluntary activation. In patients with myasthenia gravis, spinal muscular atrophy and motor neurone disease we have found that the neuromuscular jitter may increase during recordings of several minutes of continuous voluntary activation at steady innervation rates. In some units this led to impulse blocking, and in other units an initially normal jitter increased beyond the normal range. Measurement of jitter during continuous voluntary activation at steady innervation rates provides relevant information in the evaluation of neuromuscular transmission and fatigue in these disorders.

Adult↗
PubMed1985

Respiration and sleep in Parkinson's disease.

Sleep and respiration during sleep were studied in patients with idiopathic Parkinson's disease, patients with Parkinsonism with autonomic disturbance, and normal age and sex matched controls. Patients with idiopathic Parkinson's disease showed significantly reduced REM sleep, and more frequent and prolonged waking throughout the night. Hypoventilation and sleep apnoea did not occur in the idiopathic Parkinson's disease or normal groups, but respiration was disorganised with frequent central and obstructive apnoeas in the autonomic disturbance group. Respiratory rate during non rapid eye movement sleep was similar in the idiopathic Parkinson's disease and normal groups, but patients with idiopathic Parkinson's disease showed tachypnoea awake and during REM sleep.

Adult↗
PubMed1984

Effect of nitrous oxide on visual, auditory and somatosensory evoked potentials.

The effects of 10%, 30% and 50% nitrous oxide on visual, auditory and somatosensory evoked potentials were studied in seven healthy volunteers. The evoked potentials were averaged from the electroencephalogram following repeated peripheral sensory stimulation of the appropriate modality. Latencies and amplitudes of the resulting potentials were measured and compared with control values. In five subjects, increasing concentrations of nitrous oxide were associated with a graded reduction in amplitude of the visual (P less than 0.02) and somatosensory (P less than 0.02) evoked potentials. The latency of the first major negative potential of the visual evoked potential was significantly increased (P less than 0.02). Latencies of brainstem auditory evoked potentials did not alter. In the other two subjects the amplitudes of the visual and somatosensory evoked potentials showed graded increase with decreasing concentrations of nitrous oxide, confirming that the changes are dose related. As nitrous oxide is used almost universally during anaesthesia, these changes must be taken into account when assessing variations observed during operation in anaesthetic-related evoked potential studies.

Adult↗
PubMed1984

Cancer-associated myasthenic (Eaton-Lambert) syndrome: distribution of abnormality and effect of treatment.

Treatment with plasma exchange, steroids, immunosuppressant drugs and cytotoxic chemotherapy was effective in two cases of cancer-associated Eaton-Lambert myasthenic syndrome. The clinical improvement noted during treatment was accompanied by improvement in the electrophysiological abnormality; this was much more marked in abductor digiti minimi and trapezius than in extensor digitorum brevis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1980

Vomiting as a diagnostic aid in acute ischaemic cardiac pain.

The incidence of vomiting before the administration of analgesics was studied in 109 patients admitted to hospital as emergencies with prolonged ischaemic cardiac pain. In transmural myocardial infarction (58 patients) the incidence was 43% (anterior infarction 58%, inferior infarction 41%). Of the 23 patients with myocardial necrosis but without transmural infarction (that is, those with diffuse or subendocardial necrosis) and the 28 with coronary insufficiency but no necrosis, only one patient in each group experienced vomiting. When vomiting occurs early in association with cardiac pain transmural infarction may be expected in 90% of patients.

Aspartate Aminotransferases↗
PubMed1980

Recurrent insulin resistance.

The patient described developed 2 separate episodes of insulin resistance and on each occassion daily administration of soluble insulin in a daily dose of 980 units failed to achieve satisfactory control. Both episodes responded to steroid therapy. The maximum binding capacity of the serum for insulin was measured on each occasion; in the first episode it was grossly elevated whereas the second time the level was unremarkable. She is currently free of diabetic complications and satisfactorily controlled on a sulphonylurea and diet.

Chlorpropamide↗
PubMedDate not supplied

Neuropeptide signaling of lymphocytes in immunological responses.

Peptidergic nerves in immune organs and lymphoid tissues of the lungs and gastrointestinal tract end on or in close proximity to lymphocytes, mast cells and macrophages. Vasoactive intestinal peptide, substance P and some other neuropeptides, that are recognized by distinct sets of cell surface receptors, regulate aspects of T cell differentiation in the thymus, such as negative selection, and contribute to mediating compartmental immune responses. The latter effects include stimulating expression of adhesive proteins by lymphocytes, enhancement of lymphocyte and macrophage migration in vascular and connective tissues, and modulation of proliferative and synthetic responses of lymphocytes to diverse antigens.

Animals↗