PubMed Health⌕ Search

Biomedical subjects

D A Kalbhen

Publications and source records attributed to D A Kalbhen.

At least 37 records · Page 2Linked to original sources
PubMed1979

Effects of tribenoside (Glyvenol) on experimental osteoarthrosis.

An experimental model of chemically induced osteoarthrosis in the knee joint of adult hens was used to investigate the possible anti-arthrotic potency of the D-glucofuranose derivative tribenoside (Glyvenol). Development and intensity of progressing degenerative processes in the articular tissue were controlled and quantitatively determined by radiographic and macroscopic methods. Tribenoside was given in daily oral doses of 50 and 150 mg/kg by cannulation into the crop. Control of the knee joints by X-ray using mammography film as well as joint space measurements were performed at the beginning and 6, 8, 10, and 12 weeks after induction of osteoarthrosis. The results clearly demonstrate that the higher dose (150 mg/kg) of tribenoside had a significant inhibitory influence on the degenerative processes in the knee joints. The obvious anti-arthrotic potency of tribenoside may be explained by the various chondrotropic and vasotropic activities of this drug. The mode of action of tribenoside on connective tissue is discussed in relation and contrast to the inhibitory effect of most anti-inflammatory antirheumatics on anabolic cartilage metabolism.

Animals↗
PubMed1977

[Hypothesis and experimental confirmation of a new pharmacological model of osteoarthrosis (author's transl)].

Basing on the fact that in adult articular cartilage there is an equilibrium of anabolic and catabolic processes, we developed a hypothesis that an experimentally induced reduction of anabolic reactions will lead to degenerative alterations in joint cartilage. In our experiments using monoiodine acetate, a potent inhibitory substance, we could confirm that 6-8 weeks after intraarticular injection into the knee joint of hen arthrotic processes can be observed in cartilage. By macroscopical, histological and biochemical criteria these arthrotic degenerations are in good correlation with human osteoarthrosis. Our new experimental model of osteoarthrosis in laboratory animals appears to be very sutiable for the study of degenerative articular processes and for pharmacological tests of new antiarthrotic drugs.

Animals↗
PubMed1977

[Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol].

In the present study we investigated the antiinflammatory effect of pentosanpolysulfate (SP 54) in combination with metamizol using different forms of rat paw edema (induced by dextrane, hyaluronidase, trypsin, formaldehyde, carragenine or kaolin). After s. c. application Probaphen, a new drug containing pentosanpolysulfate, metamizol, and lidocaine, proved in our experiments to exert an antiphlogistic effect about 40% stronger than the equivalent amount of SP 54 alone. Since pentosanpolysulfate by itself has no analgetic activity, its combination with metamizol results in a formulation which is not only a more potent antiinflammatory drug but will aslo counteract pains which accompany most edematous reactions. Probaphen may therefore be suggested for the treatment of rheumatoid arthritis and similar inflammatory and edematous processes. First clinical studies and reports on Probaphen fully support our pharmacological results.

Aminopyrine↗
PubMed1976

[Metabolic degradation of cartilage by leucocyte enzymes under the influence of antirheumatic drugs (author's transl)].

Lately the importance and participation of leucocytes in rheumatoid arthritis have been discussed. In order to study catabolic reactions in connective tissue we investigated the autolytic liberation of mucopolysaccharides in cartilage alone and in the presence of leucocyte enzymes. Factors of optimal experimental conditions, such as pH and constituents of incubation medium, incubation time and the number of leucocytes, were determined. In further experiments we studied the influence of antirheumatic drugs, such as sodium salicylate, phenylbutazone, pentosanpoly-sulfate and gold thiopolypeptide, on cartilage degradation. In our experiments only phenylbutazone and pentosanpoly-sulfate exerted an inhibitory effect on leucocyte-stimulated degradation of cartilage. The relevance of this finding for the therapeutic use of these drugs is evaluated.

Animals↗