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Biomedical subjects

D A Linkens

Publications and source records attributed to D A Linkens.

At least 55 records · Page 3Linked to original sources
PubMed1981

Effect of diazepam on pancuronium-induced neuromuscular blockade maintained by a feedback system.

The possibility of an interaction between diazepam and pancuronium bromide was investigated in six patients undergoing general anaesthesia maintained with fentanyl, droperidol and nitrous oxide. Neuromuscular blockade was controlled using a feedback mechanism which automatically adjusted the rate of injection of pancuronium to maintain between 71.4 and 72.9% blockade. Diazepam 0.14 mg kg-1 i.v. produced blood concentrations within the therapeutic range, but did not produce consistent changes in the level of blockade, pancuronium concentration in the blood or pancuronium consumption measured over 20 min.

Adolescent↗
PubMed1979

Analysis of biological rhythms using an interactive structured autoregressive modelling technique.

A method of spectral-type analysis for rhythmic biomedical data is presented based on autoregressive modelling techniques. The emphasis has been on portability between data-processing machines, so that the programmes are written in FORTRAN 4 for the ICL 1900 series computers. The programmes are structured in blocks allowing for simple alteration to an interactive mode allowing the calculation and display of pre-filtering stages, model coefficients, the pole-zero plot, residuals, AR frequency spectrum, FFT of raw and filtered data. The method works on a small number of cycles and gives a direct read out of significant spectral components.

Animals↗
PubMed1979

A data analysis microcomputer package (DAMP) for biomedical signals.

The advent of cheap, powerful microcomputer systems makes the analysis of data via sophisticated techniques available to the personnel who are non-specialists in computing systems. The DAMP package described here is intended for use on personal computers and has therefore been written in BASIC for portability. The analysis techniques are powerful, comprising algorithms to perform sample-data generation, plotting displays, digital data filtering, auto-correlation functions, fast Fourier transforms and autoregressive modelling. The last technique contains a number of options including the display of z-plane plots, frequency response of the model, residual plotting and auto-correlation of the residuals. Illustrative results are shown from psychological mood data and rat locomotor activity. The package is designed both to instruct a user in the techniques of spectral analysis, and also to provide a range of methods for investigating time and frequency behaviour of biomedical data.

Biomedical Engineering↗
PubMed1979

Colonic myoelectrical activity in man: comparison of recording techniques and methods of analysis.

Both monopolar and bipolar recordings of human colonic myoelectrical activity have been made on 29 occasions from implanted serosal electrodes attached to either the ascending colon or transverse colon. Visual and computer analysis of the signals were made and the incidences of the two electrical rhythms present in the colon were compared for the two recording techniques, recording sites, and methods of analysis. The percentage incidence of both rhythms was similar for the mono and bipolar recording techniques in both parts of the colon. The incidence of the two rhythms in the transverse colon was approximately twice that recorded in the ascending colon, this being true for both recording techniques and methods of analysis, but neither was detected for more than 50% of the time. It is concluded that the methods of data analysis probably account for the differing incidences of electrical activity in the human colon that have been reported previously.

Adult↗