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Biomedical subjects

D A Linos

Publications and source records attributed to D A Linos.

7 recordsLinked to original sources
PubMed1990

The incidence of cholelithiasis and cholecystitis in Rochester, Minn, 1950 through 1969.

During the period 1950 through 1969, 2344 persons (755 men and 1589 women) in Rochester, Minn, met diagnostic and residency criteria for cholelithiasis. The age-adjusted average annual incidence rates per 100,000 population were 217 for men and 370 for women (adjusted rates were 255 and 276, respectively). Incidence rates increased with age in both sexes, but more rapidly so for men, so that by 70 years of age the rate for men was higher than that for women. For the decades covered in this study, no secular trend in incidence was detected for the two sexes combined or separately.

Age Factors↗
PubMed1989

Dietary and other risk factors in the aetiology of cholelithiasis: a case control study.

We studied the effect of dietary factors and a variety of other risk factors on the development of cholelithiasis through a case control study. The study involved 96 cases and 118 age and sex matched controls. All cases and controls were interviewed with regard to a variety of risk factors and frequency of consumption of over 100 food items. Analysis was done both by chi square and a multiple logistic regression model. From all the dietary factors the only ones that showed a positive statistically significantly (p less than 0.05) association was consumption of animal fat as expressed by eating all visible fat on the meat and using butter on the table. Interestingly high consumption of olive oil had a negative (protective) association with the disease. A negative association was also found with smoking and holding a job demanding hard labor.

Case-Control Studies↗
PubMed1989

Parathyroid cysts of the neck and mediastinum. Case report.

Five cases of parathyroid cyst are presented and the literature concerning this rare entity is reviewed. Three of the five cysts were located in the neck and were non-functioning. The other two were in the anterior mediastinum and functioning, and indeed were associated with hypercalcemic crisis. Four cases were treated surgically, and in one non-functioning parathyroid cyst both diagnosis and treatment were accomplished with fine-needle aspiration. The cystic appearance, color of the fluid contents, high content of parathyroid hormone and histologic features distinguish parathyroid cyst from the much commoner thyroid cyst. Non-functioning parathyroid cysts can be treated with fine-needle aspiration, whereas functioning cysts require surgical removal.

Adult↗
PubMed1978

Primary hyperparathyroidism and peptic ulcer disease.

To determine whether primary hyperparathyroidism is related to peptic ulcer disease, we evaluated 46 cases of concomitant primary hyperparathyroidism and peptic ulcer disease. Among these patients, there was no sex preponderance. The pathologic findings at parathyroid surgery, as well as the features of peptic ulcer disease, were the same as in patients with primary hyperparathyroidism or with peptic ulcer disease alone. The ulcer symptoms of 58% of the patients with adequate follow up improved after parathyroidectomy. Sixty-six percent of the patients who had active peptic ulcer disease at surgery improved as compared with only 44% of the patients who had complicated peptic ulcer disease. None of the factors studied (age, sex, serum calcium and serum parathyroid hormone levels, location, and duration of ulcer) had any effect on the peptic ulcer symptoms after parathyroidectomy. Our results and a critical review of the experimental and clinical literature suggest that the association between primary hyperparathyroidism and peptic ulcer disease is no more than coincidental.

Follow-Up Studies↗
PubMedDate not supplied

Pancreaticoduodenectomy without pancreaticojejunostomy.

A simple technique that maintains the endocrine function without the risk of pancreaticojejunostomy after Whipple's operation is described. The simple external drainage via a polyethylene tube of the pancreatic remnant without pancreaticojejunostomy has been tried and proven successful and safe.

Adenocarcinoma↗
PubMedDate not supplied

Does coffee consumption protect against thyroid disease?

In a case-control, serially matched study, 70 patients with thyroid cancer, 55 with benign thyroid disease and 71 controls were interviewed in regard to a variety of socioeconomic, social and dietary characteristics. Statistical analysis revealed a strikingly negative (p less than 0.05) association between benign and malignant thyroid disease and consumption of coffee. After adjustment for possible confounding variables, the association remained statistically significant. The mechanism by which coffee consumption may play a protective role against development of benign or malignant thyroid neoplasms may be the stimulatory effect of caffeine on the intracellular cyclic AMP production, which is known to inhibit cell growth.

Coffee↗