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Biomedical subjects

D A Makar

Publications and source records attributed to D A Makar.

At least 19 recordsLinked to original sources
PubMed1994

[The cytochemical determination of alpha-glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheral blood lymphocytes of patients with hepatobiliary system pathology].

In patients with pancreatic head cancer and virus hepatitis the lowest values of alpha glycerophosphate dehydrogenase and adenosine triphosphatase in the peripheric blood lymphocytes were determined. The dynamic study of these values in patients with pathology of liver and biliary ducts permits to estimate the disease severity course and equally with other clinico-laboratory data may have prognostic significance.

Adenosine Triphosphatases↗
PubMed1994

[The prognostic significance of natural killers and dehydrogenases of the peripheral blood lymphocytes in patients with a suppurative inflammation].

In patients with purulent inflammation foci of various location, reduction in the number of natural killers (NK) and in the activity of alpha-glycerophosphatedehydrogenase (alpha-GPDH) and adenosinetriphosphatase (ATP-ase) of lymphocytes was revealed. Maximum reduction in indices of NK, alpha-GPDH and ATP-ase was noted in patients with diffuse peritonitis, phlegmonous-gangrenous cholecystitis, destructive appendicitis. After treatment, the mentioned indices increased, but by the time of discharge of the patients from the hospital they were lower than the normal ones.

Adenosine Triphosphatases↗
PubMed1994

[The alpha-glycerolphosphate dehydrogenase and adenosinetriphosphatase activity of the peripheral blood lymphocytes in diabetics (a cytochemical determination)].

Decrease in activity of alpha-GPDG and ATP-ase observed in peripheral lymphocytes of patients with diabetes mellitus correlated well severity of the disease. The lowest indices of enzymatic activity were registered in patients with grave diabetes complicated by angiopathies, foot gangrene, and purulent inflammatory processes. Compensation of carbohydrates metabolism and improvement of clinical picture were accompanied by the trend to normalization of enzymes' activity. Dynamic study of alpha-GPDG and ATP-ase in patients with diabetes mellitus allows to evaluate degree of hypoxia, comprehend the nature of compensation mechanisms and assess effectiveness of the treatment.

Adenosine Triphosphatases↗
PubMed1993

[Cytochemical definition of oxidation-reduction enzyme activity peripheral blood lymphocytes in patients with thyrotoxic goiter].

In patients with thyrotoxic goiter (TTG), a significant decrease in the activity of alpha-glycerophosphate-dehydrogenase and adenosinetriphosphatase of the peripheric blood lymphocytes was revealed. The lowest indices were noted in patients with a severe form of TTG, who underwent strumectomy. After conservative and operative treatment of TTG, a tendency for normalization of the enzyme activity was observed. Study of changes in the activity of the oxidation-reduction lymphocytic enzymes in dynamics permits to assess the severity of the course of TTG and to control and predict the effectiveness of treatment as well.

Adenosine Triphosphatases↗
PubMed1993

[The use of direct current in cleansing the gallbladder after cholecystostomy].

The authors developed and introduced into practice a method for the treatment of acute complicated cholecystitis. It consists in the creation of laparoscopic cholecystostoma and conduction of intracystic electrophoresis of healing agents through a drain in the postoperative period. The method was used with a favorable results in 8 patients with increased operative risk.

Acute Disease↗
PubMed1992

[The significance of the lymphocyte adherence inhibition test in patients with diffuse toxic goiter].

Patients with diffuse toxic goiter reveal an increased adhesive capacity of lymphocytes evidencing a reduction of lymphokine production by lymphocytes which would suppress adhesiveness. The degree of increase of adhesive properties of lymphocytes depended on the severity of the clinical picture of diffuse toxic goiter, being higher in those with a severe course. Results of the test of lymphocyte adhesion suppression reflect the state of cellular immunity, severity of the clinical course of diffuse toxic goiter and efficacy of treatment.

Adult↗
PubMed1989

[A diagnostic algorithm in the postcholecystectomy syndrome].

The diagnostic informative value (according to the "sensitivity" and "specificity" tests) of the findings of clinical, laboratory, biochemical (CI, LI, BI), and adjuvant methods of investigation in 74 patients with postcholecystectomy syndrome (PCES), who underwent reoperations, was established. The open to general use diagnostic algorithm of PCES was determined. CI, LI, BI are preliminary screening tests. The use of adjuvant methods, their sequence and combination depend on the character of the diagnostic information obtained.

Adult↗
PubMed1989

[Treatment of patients with malignant tumors of organs in the pancreaticobiliary zone complicated by the development of emergency situations].

The results of surgical treatment of patients with cancer of the gallbladder (23), extrahepatic bile ducts (16), pancreas (28), major duodenal papilla (10), with tumour metastases in the liver (10), who developed, as a consequence of the tumour process progression, acute abdominal conditions--inflammatory syndrome, increasing jaundice, high ileus and hemorrhage are analysed. Emergency operative interventions were directed at solving the urgent situations and had, mainly, the palliative character. After the operation, 16 (21%) patients died.

Abdomen, Acute↗