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Biomedical subjects

D A Ott

Publications and source records attributed to D A Ott.

At least 37 records · Page 2Linked to original sources
PubMed1995

Concomitant repair of complete atrioventricular canal defect and transposition of the great arteries in an infant.

The case of an infant who was born with the rare presentation of complete atrioventricular canal defect and transposition of the great arteries is described. The patient underwent pulmonary banding at the age of 2 months, followed by concomitant arterial switch and repair of the atrioventricular canal defect at 20 months. Palliative banding allowed for the infant to grow and thus facilitated the later successful repair of these congenital defects.

Endocardial Cushion Defects↗
PubMed1995

Lifelong management of patients with a single functional ventricle: a protocol.

Of the wide variety of congenital heart defects, the single functional ventricle continues to be one of the most enigmatic. Compared with patients who have complex congenital heart defects and 2 functional ventricles, patients with a single functional ventricle have greater surgical and long-term morbidity and mortality, and use more medical resources. Recent investigations have shown that patients with a single functional ventricle often have very satisfactory hemodynamics soon after a modified Fontan repair but then develop dilated cardiomyopathy during the subsequent decade. The cause and pathogenesis of the cardiomyopathy have not yet been determined. Many publications have examined individual aspects of the care of these patients based on retrospective reviews, but very few have provided comprehensive prospective methods for managing patients with a single functional ventricle. We hypothesized that a comprehensive management protocol with regular review of the results would provide a better understanding of the problems encountered in these patients and thus improve long-term outcome. Herein, we present our initial protocol for the lifelong management of patients with a single functional ventricle.

Clinical Protocols↗
PubMed1994

Mechanical circulatory support in children.

Nine children (aged 1.2-15 years) have been treated with mechanical circulatory support devices at our institution. Indications for treatment were acute cardiac allograft rejection (n = 4), postcardiotomy cardiogenic shock (n = 4), and bridge to cardiac transplantation (n = 1). Eight patients required left ventricular support, and one required biventricular support. A BioMedicus centrifugal pump was used in eight patients, and a Hemopump intra-aortic axial flow device was used in one patient. In two patients, an intra-aortic balloon pump was in place at the time that circulatory support was instituted. Mechanical support time ranged from 2 to 139 h, and the average flow index was 2.31 l/min per m2. Three patients required hemodialysis during support, and one patient required re-exploration because of mediastinal hemorrhage. Recovery of native ventricular function was assessed by transthoracic or transesophageal echocardiography, and weaning from the device was achieved by gradually decreasing pump flow in increments of 0.1 to 0.5 l/min. Seven patients were successfully weaned from support. Two hospital deaths occurred after circulatory support had been discontinued: one patient died of respiratory failure and the other of gram-negative pneumonia and sepsis. The five surviving patients experienced no significant complications, and their hemodynamic indices were normal at the time of discharge. At a mean follow-up of 28.8 months, these patients are leading active unrestricted lives, with no long-term device-related sequelae. Based on this experience, mechanical circulatory support is feasible in children who experience profound circulatory failure from a variety of causes.

Adolescent↗
PubMed1993

Postcardiotomy LVAD support and transesophageal echocardiography in a child.

A case of postcardiotomy cardiogenic shock after repair of a congenital ventricular septal defect in a 5-year-old boy is reported. Mechanical circulatory support, instituted with a centrifugal left ventricular assist device, adequately supported the patient for 50 hours until recovery of native left ventricular function occurred. Transesophageal echocardiography proved to be useful in assessment of left ventricular function, allowing for timely institution and withdrawal of mechanical circulatory support.

Child, Preschool↗
PubMed1993

Computer-guided surgery for tachyarrhythmias in children: current results and expectations.

OBJECTIVES: The purpose of this report is to summarize our entire surgical experience in the treatment of tachyarrhythmias in children. We emphasize our application of a newer computerized mapping system for use in both the electrophysiology laboratory and the operating room to localize points of activation of the tachyarrhythmias. BACKGROUND: A retrospective review was undertaken to examine the results of operative procedures in 290 children undergoing surgical treatment for tachyarrhythmias from 1977 to the present. METHODS: Operative procedures were performed in 290 children and consisted of the following: surgical ablation of accessory pathways of the Kent bundle type (210 children); surgery with cryoablation for atrial ectopic tachycardia (35 children); surgical excision or cryoablation, or both, for ventricular tachycardia (26 children); cryoablation for the permanent form of junctional reciprocating tachycardia (15 children) and atrioventricular (AV) node reentrant tachycardia (4 children). RESULTS: The surgical cure rate for accessory pathway tachycardia in the era before computerized mapping was 80% (41 patients) in the period from 1977 to 1982 and 95% (86 patients) in the period from 1982 to 1988. This rate improved to 100% (83 patients) after the advent of the computerized mapping technique. These improved results are probably due to a combination of factors, including increasing experience in electrophysiologic mapping and surgery, and cannot be attributed to the computerized mapping system alone. Surgical cure or major improvement in symptoms was documented in 33 (94%) of 35 patients with atrial ectopic tachycardia. Surgical cure was accomplished in 25 (96%) of 26 patients with the complex form of ventricular tachycardia. In 19 patients with the permanent form of junctional reciprocating tachycardia and the more typical AV node reentrant tachycardia, the surgical cure rate was 100%. CONCLUSIONS: In all forms of supraventricular reentrant tachycardia that occur in children, preoperative computerized mapping techniques combined with intraoperative computerized mapping and surgical ablation can eliminate tachycardia at a success rate of close to 100%. Computerized mapping techniques are less accurate in patients with atrial ectopic tachycardia because of multiple foci and a broader surface area to be mapped. This experience demonstrates that excellent results can be achieved in the surgical treatment of tachyarrhythmias in children.

Child↗
PubMed1993

Echocardiographic predictors of left ventricular outflow tract obstruction after repair of interrupted aortic arch.

OBJECTIVES: This study was designed to identify preoperative echocardiographic predictors of left ventricular outflow tract obstruction after repair of interrupted aortic arch and ventricular septal defect closure. BACKGROUND: Left ventricular outflow tract obstruction becomes apparent in nearly 50% of patients after repair of interrupted aortic arch and ventricular septal defect closure but is seldom recognized preoperatively. METHODS: We analyzed the preoperative echocardiograms of all patients with interrupted aortic arch who had postoperative echocardiographic or catheterization data available. Thirty-seven infants (aged 1 day to 10 months, median 5 days) were included. Off-line measurements were performed on hard copies of selected images. The cross-sectional area (indexed to body surface area) and diameters (indexed to the square root of body surface area) of the left ventricular outflow tract; ascending and descending aorta; ventricular septal defect; and mitral, aortic and pulmonary valves were compared with outcome by using analysis of variance. Outcome was classified according to development of postoperative left ventricular outflow tract Doppler gradient (Group 1 < or = 20 mm Hg, Group 2 > 20 mm Hg). RESULTS: The cross-sectional area of the left ventricular outflow tract was significantly smaller in patients who did than in those who did not develop subaortic obstruction ([mean +/- SD] 0.64 +/- 0.25 vs. 1.7 +/- 1.01 cm2/m2, p < 0.004). Left ventricular outflow tract and aortic valve diameters and aortic valve area were not predictive of postoperative left ventricular outflow tract obstruction. Incidence of postoperative left ventricular outflow tract obstruction was lower (p < 0.03) in interrupted aortic arch type A (0 of 6) than in type B (15 of 31). The incidence of aberrant right subclavian artery was lower (p < 0.02) in Group 1 (6 of 22) than in Group 2 (10 of 15). CONCLUSIONS: The preoperatively measured cross-sectional area of the left ventricular outflow tract is significantly smaller in patients with interrupted aortic arch who develop subaortic obstruction postoperatively, with a left ventricular outflow tract area < or = 0.7 cm2/m2 being a sensitive predictor. Aortic arch anatomy (i.e., type of interrupted aortic arch and presence of aberrant right subclavian artery) is also predictive of postoperative left ventricular outflow tract obstruction, possibly by influencing the volume of blood flow across the left ventricular outflow tract. These data should enable preoperative identification of infants who may require surgical relief of subaortic stenosis.

Aorta, Thoracic↗
PubMed1993

Anterior translocation of the pulmonary confluence in the surgical treatment of truncus arteriosus.

A surgical technique is described for correction of truncus arteriosus type II, in which the confluence of the pulmonary arteries is translocated anteriorly to the divided truncal root. In this technique, the truncal root is reconstructed, and the ventricular septal defect is closed through a right ventriculotomy. The outflow tract of the right ventricle is reconstructed by using a cryopreserved aortic homograft, with the pulmonary artery confluence lying anteriorly to the aorta. This positioning may facilitate future reoperation in patients with this anomaly by obviating dissection around the truncal artery.

Anastomosis, Surgical↗
PubMed1992

Congenital malformations of the coronary arteries: the Texas Heart Institute experience.

Coronary artery anomalies, some of which are considered clinically insignificant, can be associated with other congenital heart defects, myocardial ischemia, and reduced life expectancy. We conducted a retrospective study to determine the efficacy of surgical treatment in 191 patients who had a total of 202 coronary artery anomalies, which were classified as anomalies of origin (88 patients), termination (93), or distribution (10). Of the 88 patients with anomalies of origin, 60 had a coronary artery arising from the pulmonary artery, 18 had a right coronary artery arising from the left anterior descending artery, and 10 had a coronary artery arising from the contralateral sinus of Valsalva. All patients with an anomaly of termination had a coronary arteriovenous fistula, and all patients with an anomaly of origin had a single coronary artery. The diagnostic and operative techniques for each of the defects are evaluated. Based on our experience, early diagnosis and surgical intervention can yield satisfactory results in patients with coronary artery anomalies, with most experiencing relief of symptoms. The operative procedures were associated with a low early and late mortality; in addition, few patients experienced complications.

Abnormalities, Multiple↗
PubMed1992

Coarctation repair in neonates with subclavian-sparing advancement flap.

A modification of the technique of using the subclavian-sparing advancement flap for severe coarctation of the aorta was successfully used in 7 neonates ranging in age from 3 to 30 days (mean age, 12 days). Four of the 7 patients had associated cardiac defects with congestive heart failure. The procedure was performed through a left thoracotomy incision, and the coarctation repair was performed by advancing the origin of the left subclavian artery as a flap while preserving flow to the left arm. No deaths occurred, and there was patency of the repair in all patients at follow-up ranging from 1 1/2 to 2 1/4 years (mean, 2 years). In 7 of the 8 patients there was no clinically significant gradient either by examination or Doppler echocardiography at follow-up. One patient underwent balloon angioplasty at the time of catheterization to evaluate other cardiac defects 1 year postoperatively, at which time he was noted to have a peak systolic gradient of 30 mm Hg across the repair site. The technique of subclavian-sparing advancement is a reasonable addition to the surgical armamentarium for coarctation repair in neonates. It provides the advantages of subclavian flap aortoplasty without sacrificing the blood supply to the left arm. Because of the unique anatomic variations associated with coarctation of the aorta, we suggest that the choice of repair be individualized for patients with this condition.

Aortic Coarctation↗
PubMed1992

Concomitant repair of aortopulmonary window and interrupted aortic arch.

Aortopulmonary window with type A interrupted aortic arch was diagnosed in 2 critically ill neonates. Echocardiographic diagnostic methods provided precise anatomic information, which allowed cardiac catheterization to be avoided before operation. Repair was undertaken through a midline sternotomy using hypothermic, low-flow cardiopulmonary bypass with subclavian turn-down in one patient and hypothermic circulatory arrest with direct aortoaortic anastomosis in the other. Both methods provided good exposure and allowed favorable anatomic repair.

Abnormalities, Multiple↗
PubMed1992

Complete atrioventricular canal defect: surgical considerations.

Complete atrioventricular canal defect is a serious and complex cardiac anomaly that is frequently associated with other congenital cardiac defects. Its natural course is ultimately fatal; 80% of children born with this defect will die within 2 years. Long-term medical therapy for complete atrioventricular canal defect is ineffective; therefore, either palliative or curative surgery is required. The risk of corrective surgery for this defect in infancy has steadily decreased because of improvements in surgical techniques, anesthesia, and postoperative management. This report describes our current surgical technique for primary corrective repair of complete atrioventricular canal defect, with a review of recent results of this procedure in 34 patients.

Journal Article↗
PubMed1992

Pulmonary artery banding and subaortic stenosis in patients with single ventricle: surgical alternatives and clinical outcome.

Subaortic obstruction is a potential problem in patients with single ventricle and a subaortic outflow chamber. Previous reports have indicated an association between pulmonary artery banding and the development of subaortic obstruction. The purpose of this study was to determine the incidence of subaortic obstruction in our patients with this cardiac anomaly who have undergone pulmonary artery banding, and to determine the eventual outcome in those who did develop obstruction. By reviewing cardiac catheterizations performed between 1977 and 1985, we found 36 patients with single ventricle and a subaortic outflow chamber. Ten patients had been lost to follow-up or had died within 3 months of banding. Twelve of the remaining 26 patients developed a pressure gradient between the left ventricle and ascending aorta, although 7 of these 12 had minimal gradients. Eight of the 12 have undergone further surgery, with the best results in patients who underwent a combined modified Fontan and Damus-Kaye-Stansel procedure. We believe that although subaortic obstruction may develop in patients with single ventricle after pulmonary artery banding, the degree of obstruction is often minimal, and in more severe cases the obstruction can be alleviated with a Damus-Kaye-Stansel procedure. (Texas Heart Institute Journal 1992; 19:15-20)

Journal Article↗