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Biomedical subjects

D A Rutter

Publications and source records attributed to D A Rutter.

16 recordsLinked to original sources
PubMed1988

Trial of a new acellular pertussis vaccine in healthy adult volunteers.

Immunogenicity and reactogenicity of a new acellular pertussis vaccine were tested in healthy adults. The vaccine contained three constituents of Bordetella pertussis; filamentous haemagglutinin, pertussis toxin (PT) and fimbriae bearing agglutinogens 2 and 3. The constituents were separately purified, treated with formaldehyde and combined with one of two aluminium adjuvants. Subjects received one dose of vaccine or an appropriate adjuvant-only preparation and were monitored for clinical responses for 7 days. Results with the two forms of vaccine were similar. Of 35 vaccinees, none had a temperature higher than 37 degrees C or a severe reaction, one had a moderate reaction (possibly due in part to intercurrent infection) and nine had mild reactions confined to localized discomfort and/or erythema or induration at the injection site. All vaccinees had good serum antibody responses to vaccine antigens measured by ELISA and for PT, by neutralization of its effects on Chinese hamster ovary cells.

Adjuvants, Immunologic↗
PubMed1985

Changes in circulating immune complex concentrations and antibody titres during treatment of Q fever endocarditis.

Serum samples from 20 patients with Q fever endocarditis were tested for the presence of circulating immune complexes to see whether their concentrations correlated with antibody titres during treatment and whether they could be used to monitor the response to antimicrobial treatment. Circulating immune complexes were found in all 20 patients. The concentrations in 15 patients correlated with either or both of the Q fever phase 1 and phase 2 antibody titres obtained during treatment. In the other five patients no correlation with the antibody titres was found. There was no association between circulating immune complex concentrations and clinical response to treatment.

Adult↗
PubMed1984

Legionella pneumophila in aerosols from shower baths.

Routine examination of the water system in an establishment where showers were used by staff after work or leisure activities revealed the presence of Legionella pneumophila. Descaling and steaming cleared the system but six months later recolonization was found to have occurred. L. pneumophila was isolated from air samples collected in the shower room whilst the shower was in operation. No clinical cases have occurred. Serological examination of those using the showers throughout the six month period together with a control group showed no evidence of infection.

Aerosols↗
PubMed1977

Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran.

Conjugation of carboxypeptidase G and arginase, two enzymes of therapeutic interest, to a soluble dextran significantly enhanced plasma persistence in normal and tumour-bearing mice. A prolonged decrease in arginine concentrations in plasma of tumour-bearing mice was demonstrated by using the dextran-linked arginase. Gel filtration of dextran-enzyme conjugate showed that enzyme activity co-chromatographed as a single peak with carbohydrate, and enzyme was shown to be covalently linked to the dextran.

Animals↗
PubMed1972

Aerosol hazards from some clinical laboratory apparatus.

Infectious diseases, such as infectious hepatitis, may be transmitted from patients to staff in clinical laboratories and dialysis units during the performance of necessary procedures. This prompted us to examine the propensity of several items of commonly used apparatus to produce aerosols of infected blood. These were a microhaematocrit centrifuge, an AutoAnalyzer stirrer, and a microtonometer. We also compared some blood sample tubes with two types of lid. The results showed that all of these are potential sources of infection for laboratory staff.

Aerosols↗