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Biomedical subjects

D A Sherlock

Publications and source records attributed to D A Sherlock.

15 recordsLinked to original sources
PubMed2005

A profile of Perthes' disease in Greater Glasgow: is there an association with deprivation?

It has been reported that there is an association between Perthes' disease and poverty. We examined the demographic data of a group of 240 children (263 hips) who presented with Perthes' disease in Greater Glasgow, where the mean deprivation scores are substantially greater than in the rest of Scotland, to see if this association applied and whether other clues to the aetiology of Perthes' disease could be found. There were 197 boys and 43 girls; 39 (16.25%) had a family history of Perthes' disease. Bone age in this series was heavily skewed towards the lower percentiles. The mean number of siblings was 1.9, with 31 (12.9%) being an only child. Maternal age at the birth of the first child showed no preponderance of older mothers. Maternal smoking during and after pregnancy was noted in 132 (55%), which compared with the 52% reported in the population of Greater Glasgow in general. Of the children in our series, 60 (25%) were in social class IV and V. However, this applies to more than half of the population of Greater Glasgow. There was no significant evidence of a preponderance of Perthes' disease in the most deprived groups. The aetiology of Perthes' disease is likely to be multifactorial and may include a genetic or deprivation influence resulting in delayed bone age.

Age Determination by Skeleton↗
PubMed2004

Obstetric brachial plexus injuries.

It is clear that OBPP will continue to be a challenge for the foreseeable future. Because it is a rare condition the best results occur in specialised units for the fairly small number of patients who do not make a full recovery within two to three months of birth. This figure varies from 10 to 80%, according to the literature. Early referral to a specialist unit if there is not full, or almost full recovery, by two months will ensure that patients with OBPP obtain the optimal treatment available.

Brachial Plexus↗
PubMed2000

The outcome of treatment of trigger thumb in children.

Our aim was to determine the outcome of the treatment of trigger thumb in children. There was a rate of spontaneous recovery of 49% in those children whose thumbs were observed before a final decision to operate was made. Spontaneous recovery occurred more commonly in children over 12 months old. All patients treated by operation had a satisfactory outcome with few complications. The overall rate of recurrence was 4.0% and it was more common in younger children. Our results suggest that a conservative approach to surgery for this condition could be adopted.

Child, Preschool↗
PubMed1995

Acute idiopathic chondrolysis and primary acetabular protrusio may be the same disease.

The case histories and investigations for five adolescent girls with a presumed diagnosis of either primary acetabular protrusio or acute idiopathic chondrolysis are presented. The follow-up ranged from three to nine years. All were treated by extensive soft-tissue release but in no case did this improve movement of the affected hip and permanent stiffness was the inevitable result. The literature is reviewed and methods of treatment are discussed in the light of the CT findings.

Acetabulum↗
PubMed1988

Traumatic anterior dislocation of the hip.

A case of traumatic anterior dislocation of the hip is presented. Reduction was easily achieved but was unstable because of disruption of the iliofemoral ligament by detachment of the anterior inferior iliac spine. A stable reduction was achieved by operative reattachment of the anterior inferior iliac spine.

Adult↗
PubMed1987

Traumatic dorsoradial dislocation of the trapezium.

Two examples of traumatic dorsoradial dislocation of the trapezium are presented. Only three cases have previously been reported. Forced flexion of the first metacarpal is probably the basic mode of dislocation. It is suggested that open reduction and Kirschner wire fixation is the treatment of choice. Late excision or arthrodesis should be used in failed cases.

Adult↗
PubMed1987

Anaesthesia and septo-optic dysplasia. Implications of missed diagnosis in the peri-operative period.

Septo-optic dysplasia (De Morsier's syndrome) is a common cause of congenital optic nerve hypoplasia. Associated abnormalities such as hypothalamic/pituitary dysfunction, hypotonia or spasticity, may result in affected children presenting for surgical procedures under general anaesthesia. A 3.5-year-old boy with the undiagnosed condition had his Achilles tendons elongated under an uncomplicated general anaesthetic. The postoperative period was complicated by coma and a major convulsive seizure which responded to glucose and steroids. The importance of awareness of this condition in short children with poor visual acuity who require general anaesthesia is stressed, and the presenting features of seven other cases are demonstrated.

Abnormalities, Multiple↗
PubMed1987

Sarcoma at the site of a single hip screw. A case report.

We report a case of malignant fibrous histiocytoma of the hip which occurred 30 years after the insertion of a single chrome-cobalt alloy screw for a slipped femoral epiphysis. The possible aetiological association between malignant tumours and metallic implants is discussed.

Adult↗
PubMed1986

Dysplasia epiphysialis hemimelica of the hip. A case report.

Dysplasia epiphysialis hemimelica most commonly presents as overgrowth of part of an epiphysis. A case of dysplasia epiphysialis hemimelica, presenting with hip pain secondary to an isolated epiphyseal exostosis of the femoral head, is reported. Excision of the osteochondroma produced complete relief of symptoms. This forme fruste of dysplasia epiphysialis hemimelica has not previously been described in the hip joint.

Adult↗
PubMed1985

Congenital subluxation of the hip. A long-term review.

In 1957 Somerville and Scott described their "direct approach" to the management of established congenital dislocation of the hip; arthrography after a period of traction served to distinguish the dislocated from the subluxated hip. We review the long-term outcome of hips which, using their criteria, were subluxated; 72 hips have been reviewed at periods ranging from 15 to 37 years after treatment by traction, closed reduction and femoral osteotomy. The results have been classified clinically and radiologically according to Severin's criteria. There was progressive deterioration with age in both clinical function and radiographic appearance: 48.5% of hips showed evidence of dysplasia or subluxation at review. The results are similar to those found in a series treated by open reduction and limbectomy, differing only in the much lower incidence of degenerative changes after closed reduction.

Child, Preschool↗
PubMed1975

Retrograde transport of horseradish peroxidase in the magnocellular neurosecretory system of the rat.

Horseradish peroxidase (HRP) was injected into the pituitary in adult rats. After 2-3 days, the neurones of the supraoptic nuclei, the magnocellular parts of the paraventricular nuclei, and the various accessory neurosecretory hypothalamic nuclei showed accumulation of HRP. The HRP reaction product consisted of fine, discrete cytoplasmic granules, and in electron micrographys it was seen to be located in the lysosome-like dense bodies of 0.4-0.6 mum diameter which are normally present in the cytoplasm of the neurosecretory neuron.es. Very little reaction product was found in the neurosecretory axons. Reaction product was also found in the hypothalamic arcuate nuclei. This was the result of an endogenous peroxidase-like activity, since it occurred in control animals which had not received HRP. This endogenous reaction product is non-neuronal. Morphologically, it takes the form of distinctive clusters of coarse granules which are seen in electron micrographs to be characteristic angular bodies of 0.7-1.0 mum diameter located in the cytoplasm of astrocytes or their processes.

Animals↗