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Biomedical subjects

D A Tobin

Publications and source records attributed to D A Tobin.

9 recordsLinked to original sources

Posthysterectomy megavoltage irradiation in the treatment of cervical carcinoma.

Current literature has demonstrated excellent results using postoperative megavoltage irradiation in patients who had simple hysterectomy in the presence of invasive cervical carcinoma. It has recently been suggested that total abdominal hysterectomy followed by postoperative irradiation should be used as a planned treatment for early-stage cervical carcinoma. Thirty-six cases of patients with cervical carcinoma treated with whole-pelvis irradiation following simple hysterectomy at the University of Louisville are reviewed.

Adult

Radiation therapy of glottic carcinoma stage I.

A detailed retrospective analysis of 81 patients with a diagnosis of glottic carcinoma stage I (T1N0M0) from 1953 to 1975 has been done. Eighty-eight per cent of the patients were male and 80 per cent of the total number were white. The majority of the patients received a dose of 64 Gy in 6 1/2 weeks. The crude 5-year actuarial survival rate was 69 per cent and the adjusted 5-year actuarial survival rate was 86 per cent. Local recurrence occurred in 12 per cent and of these 80 per cent were cured by surgery. The median time of recurrence was 25.5 months. No case of laryngeal necrosis occurred, and 10 second malignant tumors were diagnosed in the follow-up.

Aged

Electron beam therapy in head and neck tumors.

Electron beam therapy with its high energy capabilities appears promising as a therapeutic modality in head and neck neoplasms. Over a 10-year period, 153 cases of head and neck neoplasms involving the alveolar ridge, floor of mouth, buccal mucosa, retromolar trigone, tonsil, parotid, tongue, and pharynx were treated. The pharyngeal group was removed from consideration because of the unsuitability of this lesion for single port therapy. Normal standard doses and time-dose fractions are included as a basis for treatment comparison, and the influence of stage on survival is noted. Survival and tolerance of this form of treatment is comparable to photon therapy and may in fact result in fewer complications.

Electrons