PubMed Health⌕ Search

Biomedical subjects

D A Tucker

Publications and source records attributed to D A Tucker.

6 recordsLinked to original sources
PubMed1992

Basal forebrain neurons and memory: a biochemical, histological, and behavioral study of differential vulnerability to ibotenate and quisqualate.

The differential vulnerability of basal forebrain cells to ibotenate (IBO) or quisqualate (QUIS) was investigated in rats. IBO was also coinjected with cystine (CYS) or zinc (Zn). Cortical choline acetyltransferase (ChAT) and glutamate decarboxylase (GAD) activity, neurotensin receptors, and high-affinity choline uptake sites were quantified in conjunction with radioimmunoassays for neurotensin, substance P, and somatostatin; immunocytochemistry for neurotensin-, somatostatin-, Leu-enkephalin-, and ChAT-positive cells; and in situ hybridization histochemistry of somatostatin, substance P, and enkephalin mRNAs. Compared with the performance of controls, continuous alternation performance in a T maze of IBO+Zn or IBO+CYS rats was better than that of IBO rats, whereas the performance of QUIS rats was unimpaired. Of those neurotransmitter systems examined, only ChAT-immunoreactive cells were vulnerable to IBO or QUIS. However, cholinergic cell loss did not correlate with impaired performance.

Animals↗
PubMed1992

Working with the patient designated "Do not resuscitate"--how the nurse copes.

In conclusion, this study describes coping mechanisms used by the nurse when caring for DNA patients. These coping mechanisms are of two types: caring for the patient and caring for the family. Coping mechanisms used when caring for the patient include spending minimal time, avoidance, depersonalization, being present at death, and grooming the patient. Coping mechanisms used when caring for the family include personalization of care and giving information to the family. An understanding of coping strategies used by nurses in caring for DNA patients may assist staff in recognizing and dealing with feelings associated with this stressful phenomenon.

Adaptation, Psychological↗
PubMed1986

Sensory evoked responses in the intensive care unit.

Within the past decade, sensory evoked responses (SERs) have been increasingly applied in acute brain injury. In this paper, we present the rationale for this clinical application and discuss principles and practices that are important for successful measurement and interpretation of sensory evoked responses (SERs) in the intensive care unit. Fundamentals of pathophysiology and management of acute brain injury are reviewed. Varied uses of SERs in brain-injured children and adults are illustrated with case reports. Our experience suggests that SER measurement in acute brain injury is clinically challenging yet rewarding. We conclude that, with sufficient preparation, the audiologist can assume an important position on the intensive care unit team in acute management of brain injury.

Adolescent↗