PubMed Health⌕ Search

Biomedical subjects

D Abbas

Publications and source records attributed to D Abbas.

8 recordsLinked to original sources
PubMed2001

Analysis of pyridoquinoline derivatives by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.

A method using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry (LC/APCI-MS) has been developed for the characterization and determination of pyridoquinoline derivatives 4,6-bis(dimethylaminoethylamino)-2,8,10-trimethylpyrido[3,2-g]quinoline, 4,6-bis(dimethylaminoethoxy)-2,8,10-trimethylpyrido[3,2-g]quinoline and 4,6-bis[(dimethylaminoethyl)thio]-2,8,10-trimethylpyrido[3,2-g] quinoline, all with potential antitumor properties. LC separation was performed on a conventional C18 column using a binary mobile phase composed of acetonitrile and 50 mM aqueous ammonium formate at pH 3. The APCI mass spectra obtained showed that proton addition giving [M + H]+ was the common mode of ionization to the amino- and thiopyridoquinolines, whereas the alkoxypyridoquinoline was identified by the main formation of the [M - (C2H3)N(CH3)2 + H]+, followed by the [M + H]+ ion. The LC separation conditions and MS detection parameters were optimized for the determination. The analytical method was also applied to the determination of these pyridoquinoline derivatives in fetal calf serum using liquid-liquid extraction with dichloromethane. Acceptable recovery values were obtained, ranging between 45 and 98%.

Acetonitriles↗
PubMed2000

Unreamed femoral nailing.

Sixty one femoral fractures treated with ACE unreamed titanium nail (AIM femoral nail, ACE Medical, Los Angeles, CA) were studied. Ten patients died before bony union and three were lost to follow up. Forty eight fractures were followed up for an average of 11.2 months (4-31 months). All fractures united except one in which plating and bone grafting was performed at 6 months due to failure of progression of union. The mean time to bony union was 6.2 months. There was no implant failure but one distal interlocking bolt broke at 6 weeks. No incidence of adult respiratory distress syndrome (ARDS) was observed. Malunion was seen in one patient whereas three cases had shortening of more than 2 cm. Our results show that unreamed femoral nailing using titanium nail is a safe and effective procedure for the treatment of femoral shaft fractures.

Adolescent↗
PubMed1998

Never again

Explore the source record for details and available documents.

Journal Article↗
PubMed1993

Endurance exercise training in Guillain-Barre syndrome.

The purpose of this case study was to determine whether an individual who had residual deficits following an acute incidence of Guillain-Barre Syndrome (GBS) would experience improved physiological adaptations following aerobic endurance training. A 57-year-old man who needed the aid of a crutch for walking three years following an acute bout of GBS participated in this study. Peak work level (watts), oxygen consumption (VO2 mL/min; mL/kg.min), and ventilation (VE, L/min) were determined on a bicycle ergometer (BE), a Schwinn Air-Dyne ergometer (SAE), and an arm crank ergometer (ACE) before and after exercise training. Isokinetic leg strength measured using a dynamometer and total work capacity in watts using BE were also determined before and after training. The subject trained for 16 weeks at an approximate frequency of 3 days/week, an average duration of 30 minutes, and an average intensity of 75% to 80% of pretraining peak HR. A 9% and 11% improvement was seen in peak oxygen consumption for the SAE and BE, respectively. For peak ventilation, a 23% and 11% improvement was seen for the SAE and BE, respectively. For the ACE, a 16% increase in peak ventilation was seen, with no improvement in aerobic capacity. Total work capacity on the BE was improved by 29% following training. Positive improvements were also seen in isokinetic leg strength. This study demonstrated that a man still suffering residual symptoms following an incidence of GBS was able to improve his cardiopulmonary and work capacity and isokinetic strength of his legs following a supervised training program using the SAE. The subject also reported improvements in activities of daily living.

Blood Pressure↗