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Biomedical subjects

D Abrar

Publications and source records attributed to D Abrar.

12 recordsLinked to original sources
PubMed1992

[Medical interruption of pregnancy. Indications and techniques. Critical study and reflections on 324 cases].

A retrospective study of 324 cases highlights the difficulties encountered in identifying indications for medical pregnancy terminations (MPTs) which are permitted by French law and medically justified. In addition, the ethical problems raised do not facilitate the decision to opt for a MPT, which must be made by a multi-disciplinary committee. The methods used to evaluate the pregnancy are largely surgical during the first three months, and these are succeeded during the next six months by medical methods involving the use of synthetic prostaglandins. The complications which may occur are far from minor. The various protocols used by the authors are described together with their results and complications.

Abortion, Therapeutic↗
PubMed1990

[Modes of contamination in children].

The various ways in which infants may be contaminated with HIV are described. Transmission by blood perfusion persists in only some countries where HIV detection in blood products is not performed and sterilization is doubtful. Transplacental contamination is well documented by the finding of HIV in various foetal tissues, amniotic fluid, placenta and foetal blood; it seems to be predominant. Transmission during delivery and breast-feeding plays a lesser role, but it cannot be excluded. Horizontal transmission is extremely rare. The frequency of vertical transmission varies from one series to another, but the most often quoted figure is approximately 30 p. 100. An Atlanta C.D.C. stage III or IV and a low percentage of T4 lymphocytes are thought to facilitate the mother-to-foetus transmission. Many elements are still imperfectly known; their elucidation requires further studies on large series of subjects.

Breast Feeding↗
PubMed1990

[Preliminary study on the transport of AZT (Retrovir-zidovudine) through the placenta].

The authors selected six patients who were HIV positive and who had requested termination of pregnancy to study the passage of zidovudine through the placenta. After the patients had been warned about the procedure and given consent, 1 gram of zidovudine (Azitothymine) was given in five doses of 200 mg each orally. Ethical Committee consent had been obtained. At a mean age of 17.5 weeks of amenorrhoea, samples were taken from the mothers' blood, from the amniotic fluid and from the fetal blood between one and two hours and forty five minutes after the last dose of AZT had been taken. Pregnancy was terminated immediately after the amniotic fluid had been obtained. The levels of zidovudine and its metabolite glucuronide (G-AZT) were carried out using High Performance Liquid Chromatography (HPLC). The concentrations of the drug in the liquor and in the fetal blood were higher or equalled those found in the maternal blood. This makes it likely that the half life elimination was longer and the metabolism of the product slower when it had been metabolised to glucuronide. This study does not concern the teratogenic effect or the toxicity for the fetus. The drug remains contra-indicated in pregnancy. There is no proposal at present to use it to lessen transmission of the virus from the mother to the fetus.

Abortion, Therapeutic↗
PubMed1988

[Beta-mimetics and Pourcelot's index].

In a series of 20 patients presenting a threat of premature delivery, the vascular resistance index of Pourcelot, in the umbilical artery, was measured before, and then 24 hours after starting a continuous Salbutamol perfusion. A moderate but significant decreased placental vascular resistances is noted under betamimetic treatment. Relaxation of the myometrium obtained with a tocolytic treatment could be implicated in this alteration of placental resistances.

Albuterol↗
PubMed1987

[Microsurgical treatment of lesions of the proximal segment of the oviduct. Isthmo-ostial reimplantation. Isthmo-ostial anastomosis and isthmo-uterine reimplantation].

The authors, who operated on 187 patients with 277 interstitial sections of the isthmus, describe their microsurgical techniques for isthmo-ostial anastomosis, for isthmo-ostial reimplantation and for isthmo-uterine reimplantation. Histological analysis of the lesions and the anatomical features of the proximal segment of the tube justify their method. Patency is re-established and the results are encouraging. All the same, these partial proximal lesions can be markedly improved with success by medical treatment before operation.

Fallopian Tube Diseases↗
PubMedDate not supplied

[Thanatophoric nanism: a case of early ultrasonic diagnosis].

The diagnosis of a thanatophorous nanism is evoked in the presence of an abnormality of the size of the long bones. This study records the symptoms which, on sonograms, permit to recognize this fatal form of nanism among other forms of metaphysis chondrodysplasia, in order to establish a diagnosis before deciding to interrupt the pregnancy.

Adult↗
PubMedDate not supplied

[Examination of condylomatous lesions of the uterine cervix in 468 anatomic specimens. Retrospective study].

On the basis of 468 anatomical specimens, we intended to look for histological signs of an HPV (human papilloma virus) infestation. This study has enabled to calculate the true incidence of this pathology, to correlate the histo-clinical aspects as well as the association severe lesions-condylomatous lesions. Our conclusions confirm the close connection between viral lesions and malignant pathology of the cervix.

Adult↗