[Silica, silicones and connectivitis. 20 cases].
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Biomedical subjects
Publications and source records attributed to D Alcaix.
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After 5, 16 and 21 years of occupational exposure to silica, 2 men and 1 woman, respectively, were diagnosed as having dermatopolymyositis. Pulmonary impairment was always present and took the form of diffuse interstitial fibrosis in 2 patients, whose lung biopsies revealed high particulate silica contents. The role of silica in the induction of dermatopolymyositis is discussed in light of published information on silica-induced connective tissue diseases.
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The authors report two cases of muscular tuberculosis in patients with dermatomyositis treated with steroids. Antituberculous therapy with Rifampicin led to a severe relapse of the dermatomyositis in both cases, suggesting enzymatic induction inhibiting the action of the steroids.