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Biomedical subjects

D Alison

Publications and source records attributed to D Alison.

61 records · Page 4Linked to original sources
PubMed1980

[Study of dynamics and left ventricular function using radioisotopic technics in the heart cavities].

The imaging of the cardiac cavities with appropriate tracer materials (99 m Technetium or 113 m Indium), the recording of intracardiac dilution curves by radionuclide angiography and dynamic studies by gamma cinecardiography give global and regional parameters of left ventricular function which are reliable and reproducible: an index of cardiac output, intracardiac circulation times and ventricular volumes. The assessment of left ventricular contraction and global and regional ejection fractions is facilitated by coupling the gamma camera and the electrocardiogramme and computer analysis of the results. "First passage" recordings may be used to differentiate the right from the left heart chambers. "Equilibrium" studies give detailed information at rest, under stress (or leg-raising) and under pacing and/or trinitrin. Average and maximal rates of contraction derived from the ejection fraction and left ventricular contraction times are indices comparable to the rate of fibre shortening. The calculation or regional parameters point by point such as the ejection fraction, contraction time and ejection volume gives a more accurate and sensitive estimation of left ventricular function than the global left ventricular indices. They are many practical applications in cardiology especially in coronary artery disease: monitoring the changes in the acute phase of myocardial infarction, the selection of patients for aorto-coronary bypass surgery and their pre- and post-operative controls. These non-invasive, easy and reliable cardiac studies justify the development of laboratories of nuclear cardiology within departments of cardiac physiological investigation.

Animals↗
PubMed1979

[Treatment of severe chronic cardiac insufficiency with dihydralazine. Short-and median-term results].

17 patients with severe chronic heart failure (class III and IV) were prescribed hydralazine, an arterial vasodilatator, orally at doses of 150 mg to 400 mg/day. Considerable clinical improvement was observed in most patients. After 24 to 48 hours the cardiac index rose 79 p. 100, the systolic index by 67 p. 100 and left ventricular work by 73 p. 100, whilst systemic and pulmonary resistances fell by 51 p. 100 and 34 p. 100 respectively. There was no significant change in systemic blood pressure or in heart rate. These results were confirmed at 4 months. Mean pulmonary capillary pressure varied little at the start of treatment but decreased by 52 p. 100 at medium term (4 and 12 months) in this series. No cases of systemic lupus erythematosis were observed. The main, but not the only, indication of therapy with dihydralazine is low output heart failure with little elevation in the pulmonary capillary pressure, especially in primary cardiomyopathy and valvular regurgitation. At present, treatment should be based on the results of cardiac catheterisation and the dosage adjusted according to the rate of hepatic acetylation.

Administration, Oral↗
PubMedDate not supplied

Transvenous interruption of the inferior vena cava. New model of vena cava filter. Preliminary results in 35 cases.

Partial interruption of inferior vena cava (I.C.V.) forms an integral part of treatment of thromboembolic disease. The most frequently used filter worldwide is currently that of Greenfield, but although its effectiveness and permeability are remarkable it can be the subject of transfixions, sliding movements and migrations. A new model of the authors' own conception is presented which eliminates these faults. The "2612" filter is based on the same concepts, but has added to it 6 lateral flanges soldered to the base of the arms, these applying pressure to the I.V.C. and ensuring its perfect positioning, and 12 hooks (6 turned downwards and 6 upwards) ensuring perfect stability. Results of a multicentre trial in 35 patients, after insertion of the "2612" filter and follow-up assessment after 3 months (28 cases) by cavography and in some patients by a scan, showed permeability of 93% and total efficacy. No side effects were reported. This filter appears to represent true progress in the means of interrupting I.V.C., and further studies are contemplated.

Adult↗
PubMedDate not supplied

[Percutaneous bone puncture biopsy with trocar. Apropos of 60 cases].

Deep bone biopsies were performed in 58 patients over the last 2 years, in a radiology department in Tours, France, under television screen control. Data obtained included pathologic, cytologic and bacteriologic features in the 60 biopsies conducted, localization being the spine in 52 cases (12 dorsal, 36 lumbar, 4 sacroiliac) and the pelvis 8 times. Etiology was a tumoral process in 15 cases (14 metastases and 1 reticulosarcoma), 7 infectious processes including 2 cases of tuberculosis, 26 cases of decalcifying degenerative osteopathies, 1 Paget's disease, 1 ankylosing spondylitis and 1 bone infarct. Biopsy was unsuccessful in 9 cases, the success rate being an overall 85%. Complications were not observed. Conducted under local anesthesia, deep bone biopsy provides a rapid diagnosis and allows a shortened hospital stay. Surgery is generally avoided and appropriate treatment instituted more rapidly.

Adult↗
PubMedDate not supplied

[Tumor of the adrenal gland associating pheochromocytoma and ganglioneuroma (author's transl)].

An adrenal gland tumor associating of both a pheochromocytoma and a ganglioneuroma was discovered upon its fissuration in a 58-year-old male having a family history of neurofibromatosis. The patient's clinical course was fatal due to complications of necrotizing enteritis which was discovered at laparotomy. The association of pheochromocytoma, ganglioneuroma, and "café au lait" spots in the same patient illustrates the polymorphism of neural crest dysgenetic pathology.

Adrenal Gland Neoplasms↗