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Biomedical subjects

D Allbrook

Publications and source records attributed to D Allbrook.

At least 19 recordsLinked to original sources
PubMed1984

The scalpel and the pen. An experiment in combined seminars.

An experiment in education for medical and English Honours students was conducted during the 1983 academic year. Eight evening seminars were held, at which literary pieces were presented and discussed. All had relevance to medicine. No quantitative results could be deduced, but the voluntary attendance and enthusiasm remained high from beginning to end, and suggest that this is a programme worth developing.

Australia↗
PubMed1978

Cell proliferation in skeletal muscle following denervation or tenotomy. A series of autoradiographic studies.

Autoradiographic experiments using 3H-thymidine were designed to analyse cell proliferation which occurs in skeletal muscle after denervation and after tenotomy. In mouse tibialis anterior and tongue muscles during the first 24 h after denervation or tenotomy labelling levels were low and did not differ significantly from sham operated control muscles. By 48 h after denervation and tenotomy of tibialis anterior muscles, increased levels of labelling occurred in both muscle and connective tissue nuclei. Daily pulse labelling for 7 days after denervation produced a labelling level which was 8 times that of sham operated controls, 25--30% of the total nuclear population being labelled. Denervated muscles had twice the level of labelling compared to tenotomised muscles. These results provide conclusive evidence that both denervation and tenotomy stimulate cell proliferation in skeletal muscle and it is suggested that the increased numbers of labelled muscle nuclei are likely to be the result of mitotic activity in muscle satellite cells.

Animals↗
PubMed1977

Whole-muscle reimplantation with microneurovascular anastomoses. A functional and histological study.

Whole tibialis anterior muscles were removed from a number of dogs and were then reimplanted in the original sites. Microsurgical anastomoses of the major nerve, artery, and vein were performed. Biopsy revealed some minor regenerative changes in the muscle a few weeks after the operation. Electromyographic recordings 6-9 months after implantation showed near-complete functional recovery of the muscles. This was confirmed histologically. The study demonstrates not only that whole-muscle reimplantation is technically feasible but that a functionally satisfactory result may be expected.

Animals↗
PubMed1975

Transplantation and regeneration of striated muscle.

This lecture explores the factors controlling regeneration and reconstitution of skeletal muscle following vascular and neural injury by giving an account of some experimental work in this field, which is then linked to the problem of the use of whole-muscle transplants in clinical surgery.

Animals↗