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Biomedical subjects

D Anders

Publications and source records attributed to D Anders.

32 records · Page 2Linked to original sources
PubMed1975

[Sialadenitis in a boy with anorexia nervosa].

Isolated sialadenosis of both sumandibular glands and anorexia nervosa are clinical pictures found extremely seldom in boys. This paper describes a case with symptomless enlarged submandibular glands, the bioptic findings which were suggesting the diagnosis of sialadenosis, the verification of the underlying disorder by child psychiatry, and the recuperation of the boy during puberty.

Adolescent↗
PubMedDate not supplied

Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts.

OBJECTIVES AND METHODS: In idiopathic pulmonary fibrosis (IPF), proliferation of fibroblasts and increased matrix deposition result in pulmonary damage and respiratory insufficiency. We cultured human fibroblasts from lung biopsies of healthy adults and of three patients with IPF (histologically usual interstital pneumonitis, UIP) in order to compare proliferation ([(3)H]thymidine incorporation, cell count) and matrix protein expression (immune fluorescence, quantification of fibronectin synthesis using time-resolved immune fluorescence) of normal and UIP fibroblasts in response to various growth factors. FINDINGS: The growth factors platelet-derived growth factor-BB (PDGF), epidermal growth factor (EGF), insulin growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), tumor necrosis factor alpha (TNFalpha), Transforming growth factor-beta (TGFbeta(1)), and fibroblast growth factor-2 (FGF-2) stimulate proliferation of normal lung fibroblasts significantly more than proliferation of UIP fibroblasts. Immunofluorescence reveals extensive expression of collagen I, collagen III, and fibronectin induced by serum, TGFbeta(1), and TNFalpha. This expression is more pronounced in UIP fibroblasts than in normal fibroblasts. Quantification of fibronectin synthesis reveals an enhanced fibronectin synthesis by UIP fibroblasts in response to PDGF, EGF, IGF-1, IGF-2, TNFalpha, TGFbeta(1), and FGF-2). CONCLUSIONS: Fibroblasts from normal and UIP lungs differ in their response to growth factors: Whereas normal fibroblasts show a predominantly proliferative response, UIP fibroblasts show an enhanced synthetic activity. Different fibroblast responses may contribute to progressive pulmonary fibrosis in patients with UIP.

Actins↗
PubMedDate not supplied

[Membranoproliferative glomerulonephritis. Variability of a morphologically definable disease].

The term of membranoproliferative glomerulonephritis (MPGN) has emerged from the morphologic evaluation of renal biopsies. The clinical picture associated with this pattern varies between apparent acute glomerulonephritis (GN), the steroid-resistent nephrotic syndrome, a combination of both, or asymptomatic protein uria and microscopic hematuria--with or without persistent depression of serum complement (C3). The histological picture is subdivided into the classical, lobular, crescentic or focal pattern. According to fine structural differences in the basement membrane changes 3 types can be recognized. An attempt is made to summarize the present understanding of this MPGN complex in its clinical, serological and morphological variability. The condition is compared to the proliferative form of lupus nephritos. A case of focal type I MPGN is presented with documentation of three serial biopsies. The Arbeitsgemeinschaft für Pädiatrische Nephrologie is conducting a cooperative MPGN study so far including 54 children and adolescents.

Adolescent↗