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Biomedical subjects

D Apel

Publications and source records attributed to D Apel.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Prognostic value of the peroxidase index in patients with acute nonlymphoblastic leukemia].

In 91 patients with acute non-lymphoblastic leukaemia the peroxidase index was determined in blast cells or promyelocytes in bone marrow. Complete remission was obtained exclusively in patients with the value of the index 0-9% or over 69%. The duration of the remission and the survival time were significantly longer in patients with a high peroxidase index. This index may be useful for prediction of the course of acute non-lymphoblastic leukaemia in adults and its high value is associated with better prognosis.

Bone Marrow↗
PubMedDate not supplied

[Treatment of low-malignancy lymphomas by spleen irradiation].

The spleen was irradiated in 8 patients with chronic lymphatic leukaemia using RTG radiation in doses of 225 to 800 cGy for one treatment course. The follow-up after radiotherapy lasted 12.5 months on average. In 7 cases a considerable reduction was observed in the size of the spleen, and in 6 cases the absolute leucocyte and lymphocyte counts decreased by a mean of 46% and 50% respectively. In patients in late phase of the disease the improvement was short-lasting; 5 patients died (2 from infectious complications). In patients in early phase remissions of 30 months were obtained with normalization of the proportions or T and B cells During the radiotherapy a significant rise was observed in the per cent of granulocytes and a fall of albumin level. Increased gamma-globulin and uric acid levels and decreased hemoglobin level and erythrocyte count were not significant. Variable changes were noted in the platelet count. No bleeding tendency was noted. Spleen irradiation may be used in the treatment of non-Hodgkin lymphoma associated with malignant proliferation prevailing in the spleen, that is in chronic prolymphocytic leukaemia and hairy-cell leukaemia Favourable effects of spleen irradiation were observed in chronic lymphatic leukaemia and this induced us to use this method in our eight cases.

Female↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. I. Results of intensive chemotherapy of 106 patients with acute leukemia].

In a period of 5 years 106 patients with acute leukemia were treated (93 with acute nonlymphoblastic leukemia and 13 with acute lymphoblastic leukaemia. Four therapeutic programmes were used. Complete remission (CR) was achieved in 41% of patients, including 37% of those with acute non-lymphoblastic leukaemia and 77% with acute lymphoblastic leukaemia. The per cent of remissions obtained using different programmes was similar. During intensive induction treatment 22% of patients died, mainly of infections and bleeding tendency.

Acute Disease↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. V. The effect of intrathecal cytostatic therapy on leukemic changes in the central nervous system].

In a period of 5.5 years from 1975 to 1980 the neurological status of 82 patients with various forms of acute leukaemia was assessed at the Institute of Haematology and in 42 cases central nervous system involvement was found. These patients were treated by intrathecal administration of drugs according to three programmes. Remission after intrathecal treatment was achieved in 31 cases. No improvement of the neurological status was obtained in 31 cases. No improvement of the neurological status was obtained in 4 cases. Forty-eight patients without neurological signs received prophylactically intrathecal treatment which failed to prevent central nervous system leukaemia in 8 cases.

Acute Disease↗
PubMedDate not supplied

[Prognostic importance of DNA histograms of bone marrow cells in acute myeloblastic leukemias].

DNA histograms were studied in bone marrow cells in 25 patients with acute myeloblastic leukaemia before starting treatment. It was found that patients with complete remission showed a significantly higher proportion of cells in phase S of the cellular cycle (22 +/- 3%) than patients who failed to achieve remission (12 +/- 4%). Assessment of DNA citrograms of bone marrow cells may be one of prognostic factors in acute myeloblastic leukaemia.

Adolescent↗