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D Assimakopoulos

Publications and source records attributed to D Assimakopoulos.

34 records · Page 2Linked to original sources
PubMed1994

[Our experiences with cerebrospinal fluid rhinorrhea and its surgical treatment using an extracranial approach].

The cerebrospinal fluid rhinorrhea is usually due to a skull lesion and is potentially dangerous for the patient, as it can be followed by an ascending meningitis. The extracranial approach (external ethmoidectomy, osteoplasty of the frontal sinus) has substituted craniotomy, especially in cases where the cerebrospinal fluid rhinorrhea is not due to intracranial lesions. In this study, we describe the surgical treatment of 9 patients treated in our clinic, and we make a brief review of the literature.

Adipose Tissue↗
PubMed1993

Hearing loss and vestibular dysfunction in childhood from the use of streptomycin in Albania.

With the entry of a large number of Albanians in the area of Epirus over the past 8 months, a significant number of children with hearing problems or deafness has been examined in the out patient ward of the University Hospital of Ioannina. From the Pediatric-Neurologic-Psychiatric and Otorhinolaryngologic examination of these children, 18 cases with hearing problems and vestibular dysfunction due to administration of streptomycin sulfate have been defined. This article reports the ototoxic drug which has been used and is still being used in Albania, the procedure of audiological and vestibular investigation, and the damage which has been evoked in the auditory and vestibular pathway of the children in whom it has been administered.

Acoustic Impedance Tests↗
PubMed1993

[Tumors of the soft palate and the palatal vault. Our experiences].

The palate neoplasias are rare and come from either the minor salivary glands or the stratified epithelium. The malignant tumors of the hard palate are present 3-4 times more frequently than the malpighian carcinomas which, on the contrary, are prevailing at the soft palate. The malignant tumors of the palate may be located or extended to the neighbouring anatomical structures. The application of extended surgical operations for their treatment often creates great anatomical deficiencies which need the application of a reparatory intervention for restoration. We present, in this study, our experience with 6 benign and 8 malignant tumors of the hard and soft palate that we treated through surgical operation.

Adenoma↗
PubMed1993

[Capillary hemangioma of the nasal cavity. Apropos of a case].

The nasal haemangiomas are a very rare cause of epistaxis and nasal obstruction. We report a case of capillary haemangioma with the appearance of a large pedunculated nasal polyp, which was located in the middle area of the right nasal cavity's roof. We also report the clinical and histopathological findings, the differential diagnosis and the therapeutic approach of these benign angiomatous tumors.

Capillaries↗
PubMed1992

Perceptive bilateral deafness following clinical tetanus to a neonate.

A rare case of bilateral perceptive deafness following clinical tetanus is reported. The patient was a 15-day-old neonate. The clinical tetanus was treated with tetanus antitoxin (human gamma globulins) and penicillin. The exact mechanism of auditory nerve damage associated clinical tetanus and treatment with human tetanus antitoxin and penicillin is still not clearly known. We believe that the damage of the hearing organ can be attributed to the tetanus toxin and not to the human gamma globulins (tetanus antitoxin).

Audiometry, Pure-Tone↗
PubMed1992

[Our experience with surgical treatment of posterior epistaxis. Report of 16 cases].

Management of intractable posterior epistaxis remains a challenge to the otolaryngologist. When anterior and posterior packing techniques fail to control the hemorrhage, a surgical technique designed to interrupt the blood supply to the posterior parts of the nose is indicated. The common procedures employ ligation of the external carotid artery, of the maxillary artery and its terminal branch the sphenopalatine artery. Those procedures performed on 16 patients are clearly described and the indications for each one are established. Immediate control of bleeding was accomplished in 14 of 16 patients. Two patients had postoperatively recurrent but less severe epistaxis.

Epistaxis↗
PubMed1992

[Cutaneous melanoma of the cervicofacial region. Personal experiences].

The malignant melanomas are expansive tumors of neoplastic melanocytes. In the present study, five cases of patients are reported which have been hospitalized in E.N.T. department of our hospital during the last four years with skin melanomas of the head and neck. We note our opinions on diagnosis and treatment of these malignant tumors.

Adult↗
PubMed1992

[Inverted papilloma of the nose. Apropos of a case associating polyps and an inverted papilloma of the nose].

In this article is presented a case report of a 59 years old woman with a medical history of recurrent nasal polyps (from 20 years ago). This woman presented an inverted papilloma in the middle meatus of the lateral wall of the nasal cavity simultaneously with the nasal polyps, and she was faced with surgical intranasal removal. The patient, two years later, presented again nasal polyps, but without any indication of the recurrence of the inverted papilloma. It is noticed the value of the local surgical removal of the inverted papilloma in patients who do not present extensive tumors.

Female↗
PubMed1992

[The incidence of Actinomyces israeli colonization in tonsillar tissue. A histopathological study].

The presence of the Actinomyces usually is not determined by the common histologic examination of preparations of tonsillar tissue which has been removed surgically. The Actinomyces are common saprophytic microorganisms which are found inter alia in the oral cavity and palatine tonsils. In this study, the authors examined histologically 238 surgical preparations of tonsillar tissue. In 84 of these, that is 35.21%, it has been noted, except the others, the presence of Actinomyces israeli. At the same time, the authors state their views concerning the contribution of the Actinomyces of tonsillar crypts to the pathogenesis of chronic tonsillitis.

Actinomyces↗
PubMed1992

[The technic and advantages of using the tongue flap in the reconstructive surgery of cancer of the oral cavity. Our experience apropos 16 cases].

In this study, primary we present briefly the main anatomic elements that concern the tongue as also the clinical and other structures of the cancer of the oral cavity. Simultaneously, we notice our experience from the use of the tongue flap in 16 patients with cancer of the floor of the oral cavity. This procedure is simple, easy, brief and it does not cause aesthetic problems to patients. It is also emphasized that this method does not create functional disabilities to the rest part of the tongue, with result the patients not have disturbances in speech, in chewing or in swallowing.

Adult↗
PubMed1991

[Macroglossia and amyloidosis. Apropos of a case].

In the present treatise, a classification scheme for macroglossia has been formulated, based on clinical and etiological features of an enlarged tongue. The pathogenesis of each form-type of macroglossia is then described. In addition to, the authors report a case of female patient suffering from macroglossia, who was admitted in their Clinic. This pathological condition was the single and the very first clinical sign (symptom) of her, and (which) led up to the diagnosis of amyloidosis. They present the procedure of the diagnosis and differential diagnosis for this patient, they emphasize their conclusions (considerations) and make comments on the coexistence or correlation of macroglossia with amyloidosis.

Aged↗
PubMedDate not supplied

Altered patterns of retinoblastoma gene product expression in benign, premalignant and malignant epithelium of the larynx: an immunohistochemical study including correlation with p53, bcl-2 and proliferating indices.

In order to study the altered Rb, bcl-2 and p53 proteins expression during laryngeal carcinogenesis and to elucidate the role of these molecules in the development and progression of the lesions, we have examined the immunohistochemical expression of these markers in a series of 41 squamous cell carcinomas, 14 cases of in situ carcinoma, 47 with epithelial dysplasia, 11 papillomas and 20 cases of keratosis. Rb protein was expressed in 69.7% (> 5% positive neoplastic cells) of squamous cell carcinomas and p53 in 40% (> 5% positive cells). There was a strong statistically significant difference for Rb, Ki-67 and PCNA immunostaining between malignant, premalignant and benign lesions, increasing from keratosis, papillomas, dysplasia to carcinoma in situ or infiltrating squamous Ca. Rb protein expression was also strongly correlated with p53, Ki-67 and PCNA, while p53 protein was strongly correlated with Ki-67 (p = 0023) and PCNA (p = 0.0031) indices, in all lesions. In conclusion Rb and p53 altered proteins expression seems to play an active role in laryngeal carcinogenesis, probably from the early phase, and is correlated with proliferative activity. Also, Rb protein expression is correlated with the progression of the lesion and could be considered as indication of poor prognosis in laryngeal lesions.

Adult↗
PubMedDate not supplied

Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.

Clinical studies in several tumour types have shown a strong correlation between cathepsin D expression and tumour progression. Immunohistochemical staining for cathepsin D (clone D13A) was performed in paraffin embedded-tissues from 39 invasive squamous cell carcinomas, 13 in situ carcinomas, 35 cases of dysplasia, 10 papillomas and 17 cases of keratosis. The association between cathepsin D expression and CD44, p53, Rb proteins and proliferation indices (Ki-67, PCNA) was assessed by univariate analysis. Cathepsin D was highly positive in the groups of carcinomas compared to other lesions (p < 0.0001). A statistically significant correlation of cathepsin D expression with CD44 expression was observed in invasive cancers (p = 0.037). The relationship of cathepsin D immunoreactivity with p53, Rb and proliferation indices was insignificant. The results show that cathepsin D is expressed in a higher proportion of cancerous lesions of the larynx than in non cancerous or premalignant lesions, a fact which suggests that cathepsin D may be involved in laryngeal tumour cell growth process.

Carcinoma in Situ↗
PubMedDate not supplied

Prognostic significance of p53 in the cancer of the larynx.

p53 is a nuclear phosphoprotein acting as a transcription factor to regulate cell cycle progression and apoptosis, mediated by a number of target genes. p53 mutant proteins have lost a) the ability to act as sequence-specific transcription factors and b) their tumour suppressive properties. As p53 is the most commonly mutated gene in human cancer, including laryngeal squamous cell carcinoma, an aggressive and most frequent tumour of head and neck, it has attracted a great deal of interest as a prognostic factor, diagnostic tool and therapeutic target. This article reviews the current understanding of the prognostic significance of p53 in laryngeal squamous cell carcinoma. Immunohistochemical staining techniques and molecular genetics demonstrated that p53 activation is an early event in laryngeal squamous cell carcinogenesis but can not be used as a reliable prognostic marker.

Genes, p53↗
PubMedDate not supplied

Antiproliferative and anticarcinogenic effects of an aqueous preparation of Abies alba and Viscum album se abies, on a L-1210 malignant cell line and tumor-bearing Wistar rats.

Extracts of plants have been widely tested for possible anticarcinogenic properties. In the present study a traditional remedy, consisting of an aqueous extract of mixed parts of the tree Abies alba and its mistletoe Viscum album se abies was tested on benzo(alpha)pyrene(BaP)-induced tumors in Wistar rats and on the L-1210 malignant cell line. Two main groups of male Wistar rats subcutaneously injected by 10 mg of BaP, a dose inducing 100% carcinogenesis, a control group (C-G, 15 rats) and a treatment group(TR-G, 18 rats), were used for the study. Five animals bearing BaP-induced tumors were also tested (TR-1-G). Animals of the TR-G were orally administered with the aqueous extract at doses of 50 ml/kg b.w, from the day of BaP injection and of the TR-1-G, from the 120th day of injection, till death. L-1210 malignant cells in cultivation, were administered with a powder obtained by condensation and lyophilization of the extract, at various concentrations and cytotoxicity was measured by the microculture tetrazolium assay. Autopsy of the rats, revealed metastasis in the lungs of the animals of all groups and the tumors developed were histologically identified as leiomyosarcomas. The results indicated that the extract of the above plants possess anticarcinogenic effects, documented by: a) its antiproliferative effects on L-1210 cells (IC50 = 49.6 +/- 1.4 micrograms/ml), b) the significant prolongation of life and reduction of tumor growth rate of the animals of the TR-G in comparison to the C-G, c) the inhibition by 16.6% of tumor induction in the TR-G and d) the prolongation of life and the necrotic effects of the extract on the tumors of the animals in the TR-1-G. The antiproliferative effects of the Abies alba and Viscum album se abies extract may be due to the lectins and thionins contained in Viscum album, as well as to the monoterpenes contained in Abies alba. Soft tissue tumors sensitive to the extract, are widespread among human organs, even in larynx, and are usually resistant to chemotherapy.

Animals↗