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Biomedical subjects

D Atanacković

Publications and source records attributed to D Atanacković.

At least 19 recordsLinked to original sources
PubMed1996

[Acute anterior myocardial wall infarct caused by aortic dissection].

Acute myocardial infarction and aortal dissection are two different entities mostly occurring separately. According to the fact that both are severe diseases their simultaneous occurrence and interdependence present high risk for patients and a differential diagnostic dilemma for physicians. The case of S.J., a 52-year old female patient is a combination of aortic dissection and acute myocardial infarction caused by dissection of aorta and retrograde dissection of the left coronary artery main branch.

Aortic Dissection↗
PubMed1995

[Echocardiographic evaluation of left ventricular function in patients with arterial hypertension and normal left ventricular mass index].

UNLABELLED: Data about disturbances of the diastolic function of the left ventricle (LV) are well known in literature and registered even in the limited form of hypertension i.e. before the occurrence of myocardial hypertrophy. The aim of this work was to check this hypothesis in patients with arterial hypertension and normal LV mass index. The total number of examined patients was 144. The control group consisted of 30 patients, while the number of hypertensive patients in the other group was 114. The following parameters were observed: blood pressure, heart rate, systolic and diastolic dimensions of LV, wall thickness, left ventricular mass index, wall stress, endsystolic and enddiastolic volume index, cardiac index, ejection fraction, shortening fraction, velocity peak of early and late diastolic filling and their mutual relationship, integral of speed-time of early and late diastolic pressure, as well as the index of early and late filling. A significant difference was found in the size of LV mass index, wall stress, velocity peak of early diastolic filling and the relationship of velocity peak of early and late filling. It should be noted that the values of the observed parameters were in normal ranges, but those in the group of hypertensive patients were closer to pathological values. CONCLUSION: Microstructural changes of LV myocard mass can be registered in hypertensive patients before the significant enlargement of LV mass index. Diastolic disfunction of the left ventricle precedes myocardial hypertrophy.

Adult↗
PubMed1995

[90 years since the first congress of Serbian physicians].

The first congress of the south Slav physicians was held in Belgrade in 1904 and was entitled the First Congress of the Serbian Physicians and Naturalists under the presidency of Dr. Jovan Danić, the president of the Medical Society of Serbia. The Congress was attended by 433 active participants, and the work was organized in sessions: medico-pharmaceutical, physico-chemical and mathematical, biological and abiological, veterino-agronomical. Papers were printed in extenso in the proceedings and were published in the native language of the lectureres (Serbian, Croatian, Bohemian, Slovenian and Bulgarian). Out of these papers 56 were presented in the medico-pharmaceutical session. The Congress was appraised very successful by the attenders and its honorary president, Prof. Dr. Jaroslav Hlava from Prague who concluded at the end of the Congress ".. the First Serbian Congress has prepared material for the future faculty of medicine".

Congresses as Topic↗
PubMed1995

[Effect of the First Congress of Serbian Physicians and Naturalists on the Slavic population at the time].

After the First Congress of Serbian Physicians and Naturalists held in Belgrade in 1904, numerous reviews and comments were published in the Serbian and foreign magazines. This paper deals with the review of reports published in Belgrade, Zagreb, Ljubljana, Prague and Zadar. Beside some comments of the Serbian reporters pertaining to the professional level of the Congress, the general estimation was that the Congress was a great success in the professional, organization and social aspect. Furthermore, the Congress stirred up an intensive Yugoslav and Slavic temper in the participants which resulted in the initiative for the establishment of the Association of the Slavic Physicians and Naturalists.

Congresses as Topic↗
PubMed1994

[Echocardiographic evaluation of the effect of treatment with captopril in patients with essential hypertension].

Numerous antihypertensive drugs act through different mechanisms so it is natural to expect their various effects on consecutive myocardial changes. This study included 40 patients with mild or moderate hypertension: 30 patients (19 male--63.3% and 11 female--36.7%), their mean age 40.1 year, who were treated with Kaptopril (Zorkaptil), and 10 patients (6 female--60% and 4 male--40%), their mean age 37.7 years, who received placebo. Before the beginning of the treatment and three months later the following data were analyzed: blood pressure, the left ventricular mass, the left ventricular mass index, shortening fraction, ejection fraction and the endsystolic left wall stress. Three months later in the group treated with Kaptopril significant reduction of blood pressure, left ventricular mass, left ventricular mass index and endsystolic left wall stress (p < 0.05) was found. The changes concerning ejection fraction and shortening fraction were not significant. Three months later, in the group which received placebo no changes could be found. It can be concluded that Kaptopril is an effective antihypertensive drug for treating some cases of mild and moderate hypertension as monotherapy not only because it control the blood pressure, but also because it significantly reduces the wall thickness of the left ventricular mass and of the endsystolic left wall stress.

Adult↗
PubMed1993

Short-term effects of captopril (Katopil) on renal haemodynamics and function in hypertensive patients.

Short-term effects of captopril on the renal-hemodynamics and function were evaluated in 75 adult hypertensive patients. The behaviour of total and divided effective renal plasma flows (ERPF) and parenchymal mean transit time (PaMTT) implied three types of effect the premedication exerted on local renal haemodynamics and function: a protective one, no significant changes and an adverse one. In the vast majority of the cases captopril induced reduction in systemic blood pressure, was observed, irrespective of the renal response. The methodology presented seems to be a sensitive test for the selection of patients in whom an overall beneficial effect from the therapy with captopril monotherapy is expected.

Adult↗
PubMed1989

[Modern approach to the diagnosis and therapy of renovascular hypertension].

Symptoms and sings pointing most often to renovascular hypertension (RH) are the early beginning of the disease, sudden deterioration of the previous hypertension and the presence of a murmur over the flank or in the upper abdomen. The only reliable method for diagnosis is the renal angiography. Determination of the renin plasma activity (RAP) in the blood samples separately withdrawn from the renal veins and calculation of renin gradient or coefficient of its secretion are most often applied for the estimation of the functional significance of stenosis. Peripheral RAP is of no particular importance for the diagnosis of RH. In the cases then technically feasible, the percutaneous transluminal angioplasty has an advantage over the surgical revascularization. Laser thermal angioplasty and intrarenal microvascular surgical procedures are considered methods of choice in the future in some specific cases.

Humans↗
PubMed1988

The chronotropic effect of histamine, prometasin and cimetidin on rat heart.

The effect of histamine, prometasin (the blocker of histamine H-1 receptor) and cimetidin (the blocker of histamine H-2 receptor) on the frequency of the isolated right atrium of rat was studied. Histamine, prometasin and cimentidin were applied cumulatively in concentrations of 5.4 X 10(-6) to 16.3 X 10(-3) mmol/l so that each new concentration was 3.3 times higher than the preceding one. The positive chronotropic effect of histamine was shown to be strongest with a concentration of 5.4 X 10(-3) mmol/l. Prometasin and cimentidine applied in increasing concentrations gave a negative chronotropic effect. Prometasin and cimetidin applied in a concentration of 5.4 X 10(-3) mmol/l before histamine, decreased the positive chronotropic effect of histamine to more than 60% no matter whether prometasin and cimetidin were applied alone or together. This finding suggests that the effect of histamine on rat heart is mainly realized via histamine H-1 and H-2 receptors and partly through releasing catecholamines from the adrenergic nerve terminal.

Animals↗
PubMed1988

The influence of piracetam on the motor activity of rabbits with contusioned spinal cord.

Rabbits were made paraplegic by spinal cord contusion. There was a good correlation between motor function and microscopic findings. The spinal lesion significantly increased creatine kinase (CKBB) isoenzyme activity in cord tissue. Significant protection from paralysis was conveyed by piracetam (a psychoactive drug with neuroprotective activity) (2 g.kg-1 i.v.) administered once per day during 9 posttraumatic days. Piracetam significantly diminished increased activity of CKBB in the severed spinal cord. The sooner the piracetam was injected after the lesion the better protective effect was seen. No side effects of piracetam were seen.

Animals↗
PubMed1984

Effect of piracetam on motor activity of spinal cord injured rabbits.

Experimental, lumbal spinal cord compact injury provoked by a strike of 71 p.cm caused a spontaneously irreversible paraplegy in rabbits. Motor activity of injured rabbits was controlled during nine posttraumatic days. Piracetam significantly reduced motor dysfunction of the hind legs. Piracetam (2 g.kg-1) was given i.v., once per day during nine posttraumatic days. The beneficial effect of piracetam was more pronounced when the delay between trauma and the onset of drug administration was shorter. When this delay amounted to 360 minutes, piracetam did not influence significantly motor activity of contusioned animals. No side effects of piracetam were observed.

Animals↗