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Biomedical subjects

D B Cooper

Publications and source records attributed to D B Cooper.

16 recordsLinked to original sources
PubMed2001

Retrospective identification of chemical warfare agents by high-temperature automatic thermal desorption-gas chromatography-mass spectrometry.

An automated thermal desorption (ATD)-gas chromatography-mass spectrometry method was developed for the analysis of selected chemical warfare (CW) agents. Suitable methods were developed for analytes of high volatility to low volatility. The less volatile CW agents required the purchase and installation of a high-temperature valve upgrade kit allowing valve temperatures of up to 260 degrees C to be reached. The limit of detection was 50 ng on the tube for most CW agents in full scan. Chloropicrin exhibited some temperature dependence, with detection limits improving as ATD temperatures were decreased below 150 degrees C. A sample storage trial was undertaken to establish the most suitable storage environment for CW agents adsorbed onto Tenax TA. Temperature and time of storage were found to influence recovery of analytes with best recoveries being observed after 1 day storage in a freezer (-12 degrees C). This method was evaluated during a trial of procedures for sampling and identification of chemical agents at Porton Down, UK. Sulfur mustard was detected downwind of a simulated exploded munition.

Chemical Warfare Agents↗
PubMed2001

Extraction of thiodiglycol from soil using pressurised liquid extraction.

Thiodiglycol (TDG) is the predominant hydrolysis product of the chemical warfare agent sulfur mustard. The extraction of TDG was investigated using pressurised liquid extraction and the results compared for a variety of different solvents and soils. TDG was analysed underivatised by gas chromatography with flame photometric detection. A mixture of methanol-water (9:1), proved to be the most efficient extracting solvent for TDG at a temperature of 150 degrees C and 10 MPa.

Calibration↗
PubMed2001

Effects of practice on category fluency in Alzheimer's disease.

Evaluation of patients with suspected Alzheimer's disease (AD) often involves clinicians of multiple disciplines working in collaboration to maximize diagnostic accuracy. Accordingly, repeated administrations of some common tests of mental status may occur within a relatively brief time period. The effect of such retesting on subsequent results is largely unknown for many cognitive tasks, despite the possibility that repeated administrations may artificially inflate scores. To assess the potential impact of practice effects on a commonly administered verbal fluency task, animal naming was administered twice within a 1-week period to 111 patients with probable AD and 12 persons without dementia. Non-demended subjects were the only group to demonstrate a small (3 point), but statistically significant practice effect. Regardless of level of cognitive impairment, patients with AD did not show significant practice effects over repeated administrations of animal naming after a relatively brief test-retest interval, suggesting the robust nature of this task in AD.

Aged↗
PubMed2001

Helping people with alcohol problems.

Many nurses may feel reluctant to include questions on alcohol use in their general patient assessments but studies have shown that brief interventions on this subject can help people cut down on their drinking and improve their health.

Alcohol-Related Disorders↗
PubMed1995

Alcohol home detoxification.

Traditional inpatient treatments for alcohol-related problems often prevent the problem drinker from seeking early intervention. Inpatient treatment may be particularly difficult for women because of stigma, labelling and family commitments. An alternative, home-based program initiated in the United Kingdom (U.K.) in the late 1980s and currently being trialed by many health districts, may be of interest to Canadian nurses. In addition to improved client outcomes and cost-effectiveness, the program offers nurses a higher public and medical profile. Clinical nurse specialists in particular may want to consider whether the expanded role of their British colleagues might be appropriate for Canadian adaptation.

Alcoholism↗
PubMed1982

A method for hydrolyzing and determining the amino acid compositions of picomole quantities of proteins in less than 3 hours.

A method is described for quantitatively hydrolyzing proteins in 45 min and for analyzing the hydrolysates by high-performance liquid chromatography in an additional 52 min. The alpha-amino acids were detected by the fluorescence of their omicron-phthaldialdehyde derivatives. Ten picomoles of each of the commonly occurring alpha-amino acids could be reliably determined. The method described yielded OPA-ethanethiolamino acid derivatives that were stable for 1 1/2 h and the HPLC method produced a better separation than previously published methods.

Amino Acids↗
PubMedDate not supplied

Assessment and monitoring of alcohol-related problems.

Employers are increasingly requesting employees to submit to screening for alcohol-related problems (ARPs). Holistic assessment, leading to problem identification and treatment, can lead to a reduction in the number of accidents occurring in the workplace. This article argues against the practice of assessment based solely on blood levels of liver enzymes and mean corpuscular volume of erythrocytes and introduces a new diagnostic test which, if used with a full and systematic assessment, may lead to more accuracy in diagnostic interpretation.

Alcoholism↗
PubMedDate not supplied

Alcohol home detoxification: a way forward.

Alcohol detoxification within the home environment is a safe, cost-effective alternative to inpatient care and the problem drinker is more likely to complete the treatment. Yet health trusts continue to ignore this community approach for those individuals with alcohol-related problems.

Alcoholism↗